Conserved Protein Domain Family
hypF
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TIGR00143: hypF 
[NiFe] hydrogenase maturation protein HypF
A previously described regulatory effect of HypF mutatation is attributable to loss of activity of a regulatory hydrogenase. A zinc finger-like region CXXCX(18)CXXCX(24)CXXCX(18)CXXC region further supported the regulatory hypothesis. However, more recent work (PUBMED:11375153) shows the direct effect is on the activity of expressed hydrogenases with nickel/iron centers, rather than on expression. [Protein fate, Protein modification and repair]
Links
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Statistics
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PSSM-Id: 272929
Aligned: 6 rows
Threshold Bit Score: 1050.51
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q58123        45 MGNY-VEILIEGKKEdiRNFINDLKNKKPPLSRIDKLDIEEIKGiEEFDDFYIIKSeNAKDEEEGTIPaDVAICDDCLKE 123 Methanocaldococ...
Q55638        38 STQG-ATVVITADEKaiADFTERLTKTLPPPGLIEQLAVEQLPL-ESFTNFTIRPS-SDGPKTASILP-DLSTCSACLTE 113 Synechocystis s...
P30131        42 DGDG-VEVRLREDPE---TFLVQLYQHCPPLARIDSVEREPFIWsQLPTEFTIRQS-TGGTMNTQIVP-DAATCPACLAE 115 Escherichia col...
WP_010876904   1 MGNM-VEIVLEGSHEgiEEFIERLKKDKPPISRINSIKKDIFEVnEASFTEFIIKEsSSSSSGTSVIPaDVATCSSCLEE 79  Methanothermoba...
WP_001164180  54 TQAA-LEIILPAHKT--ESFLNALKKGLPPLALVEKIIISPYDKaLHFNGFRILESkNHPLNLLSQIPkDLGVCKDCLRE 130 Helicobacter py...
WP_010878863  35 TGDGsVEIVVDRNPE--E-FLNILLKERPPLVVIEDFSVAKTNG-EIPETFRIVES--GGKSLLSLPPpDVAVCDKCLEE 108 Archaeoglobus f...

Q58123       124 MLDKNDRRYRYPFIACTNCGPRFTIVEKLPYDRENTSMRDFPLCEKCLEEYKNPLDRRFHAQATCCPICGPK-VFLSDGK 202 Methanocaldococ...
Q55638       114 LFDPSDRRYLYPFINCTHCGPRYTIIEALPYDRCRTTMARFRQCTDCEREYKQPGDRRFHAQPNACPRCGPQlAFWNRQG 193 Synechocystis s...
P30131       116 MNTPGERRYRYPFINCTHCGPRFTIIRAMPYDRPFTVMAAFPLCPACDKEYRDPLDRRFHAQPVACPECGPHlEWVSHGE 195 Escherichia col...
WP_010876904  80 MMDENNRRYLYPFTACTDCGPRFTVIESIPYDRERTSMRDFPLCSSCMEEYLNPLDRRYHAEATCCPICGPK-PFLYRDG 158 Methanothermoba...
WP_001164180 131 IRDKNSPYFHYAFNSCAKCGARYSLLNALPYDRENSALKPFKLCDFCASIYQDPTNKRFHIQGISCKKCGIAlNYKRFKN 210 Helicobacter py...
WP_010878863 109 VLDSKNRRYLYPFTSCTDCGPRFTISKSLPFDRENTSLADFPLCPDCRKEYGDIKDRRYFAQTIACPRCGPQyRFVWKGG 188 Archaeoglobus f...

Q58123       203 eiiAEKDEAIRETVKLLEEGHILAIKGIGGTHLACKVGEDDVVLELRKRLGRPTQPFAVMS-KIEYTELFAEFDEDEKNA 281 Methanocaldococ...
Q55638       194 qviAEANEALNFAVDNLKVGNIIAIKGLGGFHLCCDATDFEAVEKLRLRKHRPDKPLAVMYgNLGQIVEHYQPNNLEVEL 273 Synechocystis s...
P30131       196 h--AEQEAALQAAIAQLKMGKIVAIKGIGGFHLACDARNSNAVATLRARKHRPAKPLAVMLpVADGLPDAAR------QL 267 Escherichia col...
WP_010876904 159 i--LKTHDPIKMAAELLDDGSILAVKGIGGTHLVCRADDDEVVKRLRSGLGRPNQPFACMSpDLESIESYASISDVEEEA 236 Methanothermoba...
WP_001164180 211 ------DDALLECAKDIQKGKIIALKGLGGFALLCDGRNFQTIERLRLLKNRPLKPFALMFkDLNTAKQHAFLNALECES 284 Helicobacter py...
WP_010878863 189 ------EGGIGDAANALDSGKIIAIKGIGGYHIACL-TEDDVVLRLRKLLNRPQQPFAVMVrDLSSAERVAELSNEERAE 261 Archaeoglobus f...

Q58123       282 LLSLRRPIVVLKKSQDyDKYFSkYVSNLDTIGVMFPYSGLHYLLF--DKEIAYVMTSANLPGLPMVKDNDEILKKLNGIA 359 Methanocaldococ...
Q55638       274 LQSAAAPIVLLNKKKQ-LILVEnIAPGNPRVGVMLAYTPLHHLLLk-KLKKPMVATSGNLAGEQICIDNIDALTRLQNIA 351 Synechocystis s...
P30131       268 LTTPAAPIVLVDKKYVp-ELCDdIAPDLNEVGVMLPANPLQHLLLq-ELQCPLVMTSGNLSGKPPAISNEQALADLQGIA 345 Escherichia col...
WP_010876904 237 LTSRRRPIVVLKKSRD-YCLAPsVAPGLHNIGVMLPYSGLHHVLLryTEAPAYVMTSANRPGDPMFIENTEIIGGLQGIA 315 Methanothermoba...
WP_001164180 285 LISTSAPILLARKKPD-IKLAPnIAKNSPFYGVILPYTPLHALLLd-LLDFPIVFTSANFSSLPLASDEAEI-DALSFIF 361 Helicobacter py...
WP_010878863 262 LLSPARPIVVVRKK----LPFEaVAPELDTIGIMLPYTPLHHLLFqeLKADYLVMTSANLPGEPMYIDES-IMEKME--L 334 Archaeoglobus f...

Q58123       360 DYFLLHNRRIVNRCDDSVVKKVADRLVFLRRSRGFAPEPVKVn---INNNKNILCVGAELNSTACIVKRDK--FYLTQYI 434 Methanocaldococ...
Q55638       352 DGFLVHDRPIVCPVDDSVVQIVAGKPLFLRRARGYAPQPITLp---KPTQKKLLAMGGHYKNTVAIAKQNQ--AYVSQHL 426 Synechocystis s...
P30131       346 DGFLIHNRDIVQRMDDSVVRE-SGE--MLRRSRGYVPDALALpp-gFKNVPPVLCLGADLKNTFCLVRGEQ--AVLSQHL 419 Escherichia col...
WP_010876904 316 DYFLLHDRRIVNRCDDSVVRFRGGEMAFIRRSRGYAPEPYEIp--hVAGDVSAICLGPELDVTFSVLKGGQ--CYVSQHI 391 Methanothermoba...
WP_001164180 362 DFKLTHNRAIIHRIDDSIVQHVDNAIRPMRLARGFAPLYLTLpkrsNGSPKKILALGAQQKGHFSLLDSGTsiLLLSPFC 441 Helicobacter py...
WP_010878863 335 DGFLVHNLEIANRVDDSVVKYVGGRRLLIRRSRGFVPQPIKI-----DIGFNAIAVGAELYNSIALLKEGK--AVVSQYI 407 Archaeoglobus f...

Q58123       435 GNTSKYETF-CYLRDAINNILRLTNTNKIDaIVCDLHPQFNSTKLAE----EL----SekfgAEIFRVQHHFAHAYSLLG 505 Methanocaldococ...
Q55638       427 GDLNSAPTY-QNFEEAIAHLSQLYDFSPQE-IVADLHPDYFSHQYAE----NQ----A----LPVTFVQHHYAHILAVMA 492 Synechocystis s...
P30131       420 GDLSDDGIQ-MQWREALRLMQNIYDFTPQY-VVHDAHPGYVSSQWAR----EM----N----LPTQTVLHHHAHAAACLA 485 Escherichia col...
WP_010876904 392 GNTSRYDTL-LFLKDAVDYLMGITGTEDVDvIACDLHPQFLTTSYAE----ELasrfS----AEVLRVQHHHAHALALML 462 Methanothermoba...
WP_001164180 442 GDLSVLENE-KHFKETLNFFLKTYDFKPTI-LACDKHQNYTTTQMAF----DF----N----TPLLQVQHHHAHFLASVL 507 Helicobacter py...
WP_010878863 408 GNTANFRTYnEFFKRAVKFFARYMNLEKIDyIISDMHPLFNTTNFAEklskEL----S----CRHIKVQHHFAHALSVMA 479 Archaeoglobus f...

Q58123       506 DNNy----FDDAII-LSLDGVGYGLDGNIWGGEVLLFKD--GKMERVGHLEEQYQLGGDLATKYPLRMLLSIL---Y-Ka 574 Methanocaldococ...
Q55638       493 EHGv----MEESVLgIAWDGTGYGMDGTIWGGEFLKITQ--GTWQRIAHLQPFHLLGNQQAIKYPHRIALALL---WpTf 563 Synechocystis s...
P30131       486 EHQwp--lDGGDVIaLTLDGIGMGENGALWGGECLRVNY--RECEHLGGLPAVALPGGDLAAKQPWRNLLAQC---L--- 555 Escherichia col...
WP_010876904 463 DAGv-----DECIC-IAADGVGYGDDGTSWGGEILHCHG--SDYERLGSLMPQRMPGGDLATRYPARMLLSMLrgrY-E- 532 Methanothermoba...
WP_001164180 508 DALlqdphLNHPFIgIVWDGSGAYEN-KIYGAECFVGDL--ERIEETARFEEFWLLGGQKAIKEPRRLVLEIA---L-K- 579 Helicobacter py...
WP_010878863 480 EKG-----LERAVa-ITVDGVGYGMDGKVWGGEVLLIDLekGRFERRGRLETFGLIGGDAATYRPLRIAVSLL---K-R- 548 Archaeoglobus f...

Q58123       575 iGEEAfDFIKRYNFFS------EKELRLLKFQLEKK--------LNCPITTSTGRVLDAVSALLGIC-FEKTYDGEPSIR 639 Methanocaldococ...
Q55638       564 gDDFSaDSLGNWLNFNng--fkNKINSRLNQDLNNKnlrqlwqrGQAPLTSSMGRLFDGIATLIGLI-NEVTFEGQAAIA 640 Synechocystis s...
P30131       556 ------RFVPEWQNYSetasvqQQNWSVLARAIERG--------INAPLASSCGRFFDAVAAALGCApATLSYEGEAACA 621 Escherichia col...
WP_010876904 533 -GDLQeLFSERYSDYFph---gEREIGVVMRQLESG--------LNTGISTGTGRVLDAISAALRIC-GVRTYEGECAMK 599 Methanothermoba...
WP_001164180 580 -HQLN-KLLKRVQKHFk-----EDELEIFQQMHDKK--------IQSIATNSIGRLFDIVAFSLDLT-GTISFEAESGQV 643 Helicobacter py...
WP_010878863 549 -HEL----LEHYCKYEd----vERLIKALPLAVK---------------TTSVGRFLDAVSAMLEVC-LERTYEGEPAMK 603 Archaeoglobus f...

Q58123       640 LEPVANr-------------FKGDINIEPKIKN-----N----ILnTTELIYKSYEMLLNNENKEKIAHFAHIYIADgLF 697 Methanocaldococ...
Q55638       641 LEAQIMp-------------NLTEEYYPLTLNN-----K----EK-KLAVDWRPLIKAITTEDRSKTNLIATKFHNS-LV 696 Synechocystis s...
P30131       622 LEALAA--------------SCHGVTHPVTMPR-----Vd--nQLdLATFWQQWLNWQAPVNQR---AWAFHDALAQgFA 677 Escherichia col...
WP_010876904 600 LESEAFr-------------ASGKLSMPFEVKE-----KggryILdTSAILLDVMELIDRGEDRAEIAHAAQKAVAEgLA 661 Methanothermoba...
WP_001164180 644 LENLALq-------------SDEIAFYPFEIKN-----S----VVcLKEFYQAFEKDLGVLEPE----RIAKKFFNS-LV 696 Helicobacter py...
WP_010878863 604 LEAAAEphevevkpeierrrETCVYNSPFDTEGrqgeiK----VLmLRDFFTRCMERYLEGEGRGKIAYEAIAYVARgLG 679 Archaeoglobus f...

Q58123       698 EIAKKISNKFGINTIGITGGVSYNKIITERIMNNAKREGFNFIYHQRVPNGDGGISFGQGVAYI 761 Methanocaldococcus jannaschii D...
Q55638       697 NLIITIAQQQGIEKVALGGGCFQNCYLLASTITALKKAGFSPLWPRELPPNDGAICMGQLLAKI 760 Synechocystis sp. PCC 6803 subs...
P30131       678 ALMREQATMRGITTLVFSGGVIHNRLLRARLAHYLAD--FTLLFPQSLPAGDGGLSLGQGVIAA 739 Escherichia coli K-12
WP_010876904 662 EMAVLAADDAGVKCIGGTGGVFYNEAISLAVRDYVTERGYRFIQHRNSCAGDGSVSLGQAVAVA 725 Methanothermobacter thermautotr...
WP_001164180 697 EIITALIVPFKEHVVVCSGGVFCNQLLCEQLAKRLRGLKRQYFFHKHFPPNDSSIPIGQALMAY 760 Helicobacter pylori
WP_010878863 680 EIALDAARNC---KILISGGVGYNRYFLREVERVCG----EIVVPSLYPLGDNGISLGQIYALK 736 Archaeoglobus fulgidus
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