Conserved Protein Domain Family
mutS1

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TIGR01070: mutS1 
DNA mismatch repair protein MutS
[DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273427
Aligned: 7 rows
Threshold Bit Score: 1195.74
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P44834    10 HTPMMQQYLKLKAENPDILLFYRMGDFYELFYDDAKKAAALLDISLTKRGQSAGQPIPMAGMPYHAVEGYLAKLVQLGES 89  Haemophilus influen...
P23909    10 HTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGES 89  Escherichia coli K-12
P27345     7 HTPMMQQYWKLKREHPDQLMFYRMGDFYELFYEDAKKAAKLLDITLTARGQSAGKSIPMAGIPFHSVEGYLAKLVKLGES 86  Azotobacter vinelandii
Q56215    13 LPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHK-TSKDFTTPMAGIPLRAFEAYAERLLKMGFR 91  Thermus aquaticus
BAA09880  21 LPPLLQQYVELRDRYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHK-TSKDFTTPMAGIPIRAFDAYAERLLKMGFR 99  Thermus thermophilu...
P10564     6 LSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYK 85  Streptococcus pneum...
P49849     4 yTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQELEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYK 83  Bacillus subtilis s...
P44834    90 VAICEQIGDPTTSKGPVERQIVRIVTPGTVSDEALLPERQDNLIAAVYQEKEKFGLATLDMTSGRFQLCEPADKETLRAE 169 Haemophilus influen...
P23909    90 VAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAE 169 Escherichia coli K-12
P27345    87 VAICEQIGDPATTKGPVERQVVRIITPGTVSDEALLDERRDNLLAAVVGDERLFGLAILDITSGRFNVQEIQGWENLLAE 166 Azotobacter vinelandii
Q56215    92 LAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLP-REANYLAAIATG-DGWGLAFLDVSTGEFKGTVLKSKSALYDE 169 Thermus aquaticus
BAA09880 100 LAVADQVEPAEEAEGLVRREVTQLLTPGTLTQEALLP-REANYLAAIATG-DGWGLAFLDVSTGEFKGTLLKSKSALYDE 177 Thermus thermophilu...
P10564    86 VAIAEQMEDPKQAVGVVKREVVQVITPGTVVDS-SKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTLVCGE 164 Streptococcus pneum...
P49849    84 VAICEQTEDPKAAKGVVKREVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDVISE 163 Bacillus subtilis s...
P44834   170 LQRIAPVELLYCEEFNEMAAIEHCkglrrrpiwEFELSTAITLLNRQFGTKDLRAFGVEKSPLGLSAAGCLLQYAKETQR 249 Haemophilus influen...
P23909   170 LQRTNPAELLYAEDFAEMSLIEGRrglrrrplwEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQR 249 Escherichia coli K-12
P27345   167 LERLNPAELLYPDDWPAGLPLEKRrgahrrapwDFDFDSAYKSLCQQFATQDLKGFGCDGLGLAIGAAGCLLAYARETQR 246 Azotobacter vinelandii
Q56215   170 LFRHRPAEVLLAPELLENGAFLD----------EFRKRFPVMLSEAPFEPEGEGPLALRR------ARGALLAYAQRTQG 233 Thermus aquaticus
BAA09880 178 LFRHRPAEVLLAPELRENEAFVA----------EFRKRFPVMLSEAPFEPQGEGPLALRR------AQGALLAYARATQG 241 Thermus thermophilu...
P10564   165 IRNLKAREVVLGYDLSEEEEQILS----------RQMN-LVLSYEK-ESFEDLHLLDLRLATVEQTASSKLLQYVHRTQM 232 Streptococcus pneum...
P49849   164 IYSVGAREIVVSGSLDADTVAQLR----------ERCG-ATISIEDGETDEHVTIIEHLNNEDITKTFLRLYTYLKRTQK 232 Bacillus subtilis s...
P44834   250 TALPHIQSISLIQNQDCIQLDAATRRNLELTQNLAGG-TENTLASVLDKCVTPMGSRLLKRWIHQPVRDVEKLKQRQQSI 328 Haemophilus influen...
P23909   250 TTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGG-AENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTI 328 Escherichia coli K-12
P27345   247 TALPHLRGLRHERLDDTVILAGASRRNLELDVNLSGG-RDNTLQSVIDRCQTAMGSRLLGRWLNRPLRDRAVLEARQDTV 325 Azotobacter vinelandii
Q56215   234 GALS-LQPFRFYDPGAFMRLPEATLRALEVFEPLRG---QDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRV 309 Thermus aquaticus
BAA09880 242 GALS-VRPFRLYDPGAFVRLPEASLKALEVFEPLRG---QDTLFGVLDETRTAPGRRLLQAWLRHPLLERGPLEARLDRV 317 Thermus thermophilu...
P10564   233 RELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGkKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVV 312 Streptococcus pneum...
P49849   233 RSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKnKKGSLLWLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMV 312 Bacillus subtilis s...
P44834   329 AEILn-fDLVDELQPYLQLVGDMERILARVALRSARPRDLTRLRTALEQIPALRAIVQQKTPPFLTALFSQIADFSEQCD 407 Haemophilus influen...
P23909   329 GALQ---DFTAGLQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRD 405 Escherichia coli K-12
P27345   326 ACLLq-dYRFESLQPQLKEIGDVERILARIGLRNARPRDLARLRDALAALPQLQTALSPLEAPHLQALAGNIRTYPELAE 404 Azotobacter vinelandii
Q56215   310 EGFVregALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVG---------LPDLSPLKE 380 Thermus aquaticus
BAA09880 318 ERFVregALREGVRRLLFRLADLERLATRLELSRASPRDLAALRRSLEILPELKGLLGEEVG---------LPDLSGLLE 388 Thermus thermophilu...
P10564   313 QVFLdhfFERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELES 392 Streptococcus pneum...
P49849   313 ETLMshfFEREDLRERLKEVYDLERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE 392 Bacillus subtilis s...
P44834   408 LLQRALIETPPLLIRDGGVIAEGYNAELDEWRMLSDGATQYLENLEKRERESTGIDTLKIGFNAVHGYYIQISQGQAHKA 487 Haemophilus influen...
P23909   406 LLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLA 485 Escherichia coli K-12
P27345   405 LLRRAIIDNPPAVIRDGGVLKQGYDAELDELLSLSENAGQFLMDLEAREKARTGLPNLKVGYNRIHGYYIELPRVQAEQA 484 Azotobacter vinelandii
Q56215   381 ELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERV 460 Thermus aquaticus
BAA09880 389 ELRAALVEDPPLKVSEGGLIREGYDPDLDALRRAHAEGVAYFLDLEAREKERTGIPTLKVGYNAVFGYYLEVTRPYYEKV 468 Thermus thermophilu...
P10564   393 LISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNV 472 Streptococcus pneum...
P49849   393 LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSLKVGFNKVFGYYIEVTKANLHLL 472 Bacillus subtilis s...
P44834   488 P-IHYVRRQTLKNAERYIIPELKEYEDKVLKSKGAALALEKQLYDELFDLLLPHLGSLQLASLALSELDVLVNLAERADT 566 Haemophilus influen...
P23909   486 P-INYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYT 564 Escherichia coli K-12
P27345   485 P-ADYIRRQTLKGAERFITPELKAFEDKALSAKSRALAREKALYEELLEILIAQLAPLQETATALAELDVLANLAERALN 563 Azotobacter vinelandii
Q56215   461 P-KEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVR 539 Thermus aquaticus
BAA09880 469 P-QEYRPVQTLKDRQRYTLPEMKERERELYRLEALIKRREEEVFLALRERARKEAEALREAARILAELDVYAALAEVAVR 547 Thermus thermophilu...
P10564   473 P-AHFFRKATLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAET 551 Streptococcus pneum...
P49849   473 EeGRYERKQTLTNAERYITPELKEKEALILEAENNICELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISEN 552 Bacillus subtilis s...
P44834   567 LNYVMPTFCDEVSVKIKNGRHPVVEQVL-KDPFIANPVELNHNRHLLVITGPNMGGKSTYMRQTALITLLAYIGSFVPAD 645 Haemophilus influen...
P23909   565 LNYTCPTFIDKPGIRITEGRHPVVEQVL-NEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQ 643 Escherichia coli K-12
P27345   564 LDFNRPRFVEEPCLRIRQGRHPVVEQVL-DTPFVANDLELDDNTRMLIITGPNMGGKSTYMRQTALIVLLAHIGSFVPAQ 642 Azotobacter vinelandii
Q56215   540 YGYVRPRFGDR--LQIRAGRHPVVER---RTEFVPNDLEMAH--ELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAE 612 Thermus aquaticus
BAA09880 548 HGYTRPRFGER--LRIRAGRHPVVER---RTAFVPNDLEMAH--ELVLVTGPNMAGKSTFLRQTALIALLAQIGSFVPAE 620 Thermus thermophilu...
P10564   552 QHLIRPEFGDDSQIDIRKGRHAVVEKVMgAQTYIPNTIQMAEDTSIQLVTGPNMSGKSTYMRQLAMTAVMAQLGSYVPAE 631 Streptococcus pneum...
P49849   553 RHYTKPEFSKD-EVEVIEGRHPVVEKVMdSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQIGCFVPAK 631 Bacillus subtilis s...
P44834   646 SARIGPIDRIFTRIGASDDLASGRSTFMVEMTEMANILHQATAQSLVLIDEIGRGTSTYDGLSLAWACAEWLSKKIRSLT 725 Haemophilus influen...
P23909   644 KVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALT 723 Escherichia coli K-12
P27345   643 SCELSLVDRIFTRIGSSDDLAGGRSTFMVEMSETANILHNASERSLVLMDEVGRGTSTFDGLSLAWAAAEHLAG-LRAWT 721 Azotobacter vinelandii
Q56215   613 EAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHE-RRAYT 691 Thermus aquaticus
BAA09880 621 EAELPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALVLKEATERSLVLLDEVGRGTSSLDGVAIATALAEALHE-RRCYT 699 Thermus thermophilu...
P10564   632 SAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKT 711 Streptococcus pneum...
P49849   632 KAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDEIGRGTSTYDGMALAQAIIEYVHDHIGAKT 711 Bacillus subtilis s...
P44834   726 LFATHYFELTALPEQLEGIANIHLDALEHNNTIAFMHAVQNGAASKSYGLAVAALAGVPQSVIKLAKQKLTQLEKNSSYS 805 Haemophilus influen...
P23909   724 LFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESISPNA 803 Escherichia coli K-12
P27345   722 LFATHYFELTVLAESQPVVANVHLSATEHNERIVFLHHVLPGPASQSYGLAVAQLAGVPGPVISRAREHLARLEATSLPH 801 Azotobacter vinelandii
Q56215   692 LFATHYFELTALG--LPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAAR---R 766 Thermus aquaticus
BAA09880 700 LFATHYFELTALA--LPRLKNLHVAAKEEEGGLVFYHQVLPGPASKSYGVEVAEMAGLPKEVVERARALLSAMAAR---R 774 Thermus thermophilu...
P10564   712 LFATHYHELTSLESSLQHLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTES 791 Streptococcus pneum...
P49849   712 LFSTHYHELTVLEDKLPQLKNVHVRAEEYNGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKP 791 Bacillus subtilis s...
P44834   806 AEQQIQALREAnhnqgELFFEQETDALREAIEK-----------LDPDDLSPKQALAYLYQLKK 858 Haemophilus influenzae Rd KW20
P23909   804 AATQVDGTQMS-----LLSVPEETSPAVEALEN-----------LDPDSLTPRQALEWIYRLKS 851 Escherichia coli K-12
P27345   802 EAPLREAGKPQpp-iqSDLFASLPHPLMEELAR-----------LKPDDLSPRQALELLYSWKT 853 Azotobacter vinelandii
Q56215   767 --------------------EGALDAVLERLLA-----------LDPDRLTPLEALRLLQELKa 799 Thermus aquaticus
BAA09880 775 --------------------EGALEEVLERLLA-----------LDPDRLTPLEALRFLHELKa 807 Thermus thermophilus HB8
P10564   792 PPPMR--QTSAvteqiSLFDRAEEHPILAELAK-----------LDVYNMTPMQVMNVLVELKQ 842 Streptococcus pneumoniae
P49849   792 EVPVQKPQVKEepaqlSFFDEAEKPAETPKLSKkekqvidafksLNILDMTPLEAMNEMYKLQK 855 Bacillus subtilis subsp. subtilis s...
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