Conserved Protein Domain Family
murJ_mviN

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TIGR01695: murJ_mviN 
murein biosynthesis integral membrane protein MurJ
This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Statistics
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PSSM-Id: 273763
Aligned: 11 rows
Threshold Bit Score: 346.233
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAB42720     274 GLLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTV--GGGLNSVFVPQLVRAMKDD--ED 349 Streptomyces co...
P56882         2 SLVKKFATVGGATLGSRLFGFIRETFMAAALGTGPVADAFNTAFRLPNTFRRLFA--EGAFNSAFVPLFAKEIEAHgmDG 79  Sinorhizobium m...
P75932         2 NLLKSLAAVSSMTMFSRVLGFARDAIVARIFGAGMATDAFFVAFKLPNLLRRIFA--EGAFSQAFVPILAEYKSKQgeDA 79  Escherichia coli
O83529         6 SLLKSGLLLSLLTLVSRVLGLAREVVKSTLMGTSATADAFTVAFMIPNLFRRLFA--ENAISVAFIPVFTQHYSMPssAQ 83  Treponema palli...
Q9WXU1         2 SSIKKTLAFSLGTFFSRITGLVRDIILAKTFGASSTLDAYYVSIVFPFFLRRTFA--EGAMSSAFMAIYKKLKNKE---E 76  Thermotoga mari...
O51750         3 KYVVSTILVMISTFFSRIMGFVKIKIFSYYFGANLDADIFNYVFNIPNNLRKILS--EGAMTSAFLPEFTHEKNKSheKA 80  Borrelia burgdo...
O67658         3 SLFRASLLFSLGILLSRIFGYVRDATVAYYFGASAVSDAFFIAFRIPNAFRRIFG--EGGFNAVFIPFYGEAVKQN--RE 78  Aquifex aeolicu...
AAK80987       8 SLLKVTSMVIIINLLSKITGFIRDFITASKFGTSVSADAFSMSSVVPNIIFAILG---AAIVNTFVPIFNDVIVNKgeKR 84  Clostridium ace...
Q55179        10 SLANIAGIVAIATLISKVFGLLREQIIAAAFGVGTVVTAYAYAYVIPGFLFILLGgiNGPFHSALVSVLSKRDREE---- 85  Synechocystis s...
WP_010887143  57 SLQANTLIVMAGTLGSRLSGIVRQQVIN-LFDTTLT-DAFNVAIKVPNLMRELLA--EGALVNSFIPVYKTLDAAE---- 128 Deinococcus rad...
WP_002852456   4 lVFKNFIINALGILFSRILGLARDVLIALFLGAGLYSDIFFVALKMPAFFRRIFA--EGAFGQSFLPNFVKAKKKG---- 77  Campylobacter j...
CAB42720     350 GGEAFANRLLTLVMVALGALTVITVFAAPLLIRLLSNPvASDPAAn-EVGITFVRYFLPSIFFMGLHVVMGQVLNARGRF 428 Streptomyces co...
P56882        80 ARRFSEEVFGVLFTVLLLLTIAMELSMPFIVGQLIAPG-FADDPAkfTSTVTFATIMFPYLACMSLAAMMAGMLNSLHRY 158 Sinorhizobium m...
P75932        80 TR-VFVSYVSGLLTLALAVVTVAGMLAAPWVIMVTAPG-FADTADkfALTSQLLKITFPYILLISLASLVGAILNTWNRF 157 Escherichia coli
O83529        84 VPCSSKTKEFLSAIFTLMSSVTASISLIGILGAPYIVRlFDTDQ---SLTVSLTRLMFPYLWMISLAAFFQGMLHSIKVF 160 Treponema palli...
Q9WXU1        77 -KAQFTSAVLTSLGLVTLLIVFLSEVFPYFMASIFATG-ADEEVK--SLAADLIRLTAPFITIVFVWAVFYSVHNASHRY 152 Thermotoga mari...
O51750        81 VS--FFRTVITFNIISIGLIVLVMIIFAKPIMYFISY--YRGENl--IFASSVFGYLVLYILLISLSSIFVSVLNSYKIF 154 Borrelia burgdo...
O67658        79 EE--FLRKTFGLLITFSLSVVIIGLLFPEEIISVISPG-IKEKEt-fSYAVEFLKFTILYLPLVSFYAYSMAILLVQGKF 154 Aquifex aeolicu...
AAK80987      85 AFKFSNNVITVLTLLSIILTLLGEIFCPQFVKLIAPD--FHGYKy--LLTIKLTRIFLLIIIVNTWVFLSTAILQAKEHF 160 Clostridium ace...
Q55179        86 AAP-LVETVTTLVSGVLLGVTIILVLGAGIFIDLLAPG-LEPETR--RMAVQQLQIMAPMALLSGLIGIGFGTLNAADQY 161 Synechocystis s...
WP_010887143 129 -RRKLAQSFSGFLIAINLLLMALGIFAAPWVVGLLTST-HANIDR--AIAIYMTQLVMPFLTLISLSAVAMGLLNADEHF 204 Deinococcus rad...
WP_002852456  78 ---AFCVSVMMQFSLIVFLFCLLVSFFSSFFTKLFAFG-FNADTI--ALAAPLVAINFWYLFFIFLVTFLGAILNYRQKF 151 Campylobacter j...
CAB42720     429 GAMMWTPVLNNIVIIVTLGLFIWVYGTAETSgmkVTsippegerllgIGVLLGLIVQSLAMIPYLRETg----FRLRLRF 504 Streptomyces co...
P56882       159 FAAAIAPVFLNFILIAVLAYAWYSGQDAVAVgydLS-----------WGVLAAGLVQLAIVWVAVRNAg----IRIGFRR 223 Sinorhizobium m...
P75932       158 SIPAFAPTLLNISMIGFALFAAPYFNPPVLA---LA-----------WAVTVGGVLQLVYQLPHLKKIg----MLVLPRI 219 Escherichia coli
O83529       161 VPSGCTPIFFNVSVIFSMYFLNVSHMNVAIA---AA-----------IGVLIGGCAQALFQLIFVYMHgf-rfTLQSPLK 225 Treponema palli...
Q9WXU1       153 FLPALTPMFSNVGVIVGCLFGDVRWAA--------------------AGFTIGGLAALLVLLPFG-----------KFRY 201 Thermotoga mari...
O51750       155 FIPSFSPIMLSFGIILSIFLFYGRFGIYSAV----------------IGVIFGGFLQFLIPFANCLMIg----FAWKPTF 214 Borrelia burgdo...
O67658       155 FVPSVSQTLFNLGFILSLVILFHTLGHYSLA----------------LAVLIGGLFQIIPNTFLLFKEk----LLKIPKF 214 Aquifex aeolicu...
AAK80987     161 LIPSLIGIPYNLLVIVYLLFFSSKYGVLGLT----------------EVIVFAMFVQFLIHVPSLARMk----YRYKPEF 220 Clostridium ace...
Q55179       162 LLPSISPLLSSITVILGLGVAVWQLGQQLNTepyWLlgsl----llaGGTTAGAVLQWLAQIVPQAKAg---mGKLRLRF 234 Synechocystis s...
WP_010887143 205 RESSFAPVAFNIASIIALLLLPNNATW-------LA-----------FGWLIGGVAQLLVQLPALRRFg----LLPEPRL 262 Deinococcus rad...
WP_002852456 152 FITSFSAALFNLSIVIAAFFVDKNAPQNTLYy--FS-----------YATVLSGVAQLILHLLVLKNNpviraMTLSIKF 218 Campylobacter j...
CAB42720     505 DWRGHGLGKAITLAKWTVLFVLANQAGAMIVIqlstaaGK---ASPVDGtGFAAYANAQLIWGLPQAIITVSLMAALLPR 581 Streptomyces co...
P56882       224 PRLTPNVKRLLVLALPAAITGGITQINLLINT------NI---ASAKEG-AVSSLVYADRIYQLPLGVVGIAVATVLLPE 293 Sinorhizobium m...
P75932       220 NFHDAGAMRVVKQMGPAILGVSVSQISLIINT------IF---ASFLASgSVSWMYYADRLMEFPSGVLGVALGTILLPS 290 Escherichia coli
O83529       226 AMHDEGVRRIIALLLPTTVGIATYLLNDLVCT------AL---ATSVEIgVAASVQYSLRIQELLLGIFIVSLSSVVLPD 296 Treponema palli...
Q9WXU1       202 RPTFKGLGEFYRLFFGTFMTMAVSQVTTLIDV------NV---ASFLDPgSLSLIQLSSRLYQLPLGIFGVAVSTVALST 272 Thermotoga mari...
O51750       215 YFREKVFLNFLTRWLRMIFGFSISIITQQISF------AL---ASTLEIgSVSILSNAVVYYQLPVGIFYISIATVIFPK 285 Borrelia burgdo...
O67658       215 S-LDREIKTFLKKFLFTLGGFSANQLSLFVDT------FL---ASFLKVgSISYVYYAARIYLLPISLFSISLSNTLLAL 284 Aquifex aeolicu...
AAK80987     221 NISDGYLKSMVVLLIPILLGTSVQQITSLFNG------RF---SSSLETgSVAALSYASRLNSLVMDIFVISIVTVIYPK 291 Clostridium ace...
Q55179       235 NFALPGVKEVLQVMIPATLSSGMLYINFATNL------FF---ASFIPN-AAAAMRYGNFVALTPLGIISNMILVPFLPV 304 Synechocystis s...
WP_010887143 263 G-GHPALGRVLKQMAPFTLTAGARQFLNLYVT------RLltdASQFKPgTQTGYANAEALFTMANGLFVVSPALAVFPR 335 Deinococcus rad...
WP_002852456 219 KKTKAKLQGFYGNFFHGVLGSSATQFSSLLDT------TI---ASFLMSgSISYLYYANRVFQLPLALFAIALTQVSFPK 289 Campylobacter j...
CAB42720     582 ISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSS--GTSEATNMGYMLMAFGLGLIPYSVQYVV 659 Streptomyces co...
P56882       294 LARALRGGNLNEAANLQNRSVEFTLFLTLPAAAALLVMSEPIVRLLFERGqfSPESTVVVGHILAIYGLGLPAFVLIKAF 373 Sinorhizobium m...
P75932       291 LSKSFASGNHDEYNRLMDWGLRLCFLLALPSAVALGILSGPLTVSLFQYGkfTAFDALMTQRALIAYSVGLIGLIVVKVL 370 Escherichia coli
O83529       297 LSFHVMRKDWQSFEDLLITAIKIVMLITIPATFFVLFSSDRIITLVYKNAifNELSVRMTATIFRWHSVGMLAIALNRVL 376 Treponema palli...
Q9WXU1       273 LSESEGD-----FHENLKDFISKSLFLTLPSSIGLMALSERIISLLFGYGafTHEDVKKSAQILFMYAIGLCFVSLFNLL 347 Thermotoga mari...
O51750       286 MAEHAVLGNNIKLNALLVDGIKILLLIFIPVSFLMFIWSDYILNLFLMGGkfSIYDTQKTASVLKCFLLGLLFYSMFGFF 365 Borrelia burgdo...
O67658       285 VSTKKDK------EKDTDTALKLTLMLSIPSSFGLFFLSREIVSVLYKRGnfSEEDLFYTSGLLSLYAFSVPFYSLQHIL 358 Aquifex aeolicu...
AAK80987     292 MTKLSSENKIGELIESFNISIRSITIILFPIITIILIESVPIVKILFQRDafGNKSTLMTSTALFYYIIGIIAAGLREVL 371 Clostridium ace...
Q55179       305 FSRLADPQDWPELKLRIRQGIMLSALTMFPLTAILVGLAIPIVQVIYERGafDAEAAAEVAPVLAAYGLGMFFYLGRDVL 384 Synechocystis s...
WP_010887143 336 FSQHAAEGNWNEFRSLTAQTIRTSTFLAAPVSALLLVLAPYAVSVYNLKSgfDPNRFEAGSGILAGWALALIPWALVTIL 415 Deinococcus rad...
WP_002852456 290 ILKHLKSDQENLALKFMQRALALLSILLIASSIVGSVFALEISKLLFERGnfTHEDSVITAYVLIAYLIGLLPFGLQKLF 369 Campylobacter j...
CAB42720     660 LRAFYAYEDTRTPFYNTVIVAVVNAAASglcyLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGDLDgARVLRTY 739 Streptomyces co...
P56882       374 IPGFFAREDTRTPMIFAGISVAVNVSLA----LTLFPSLAASGIATAEIVAGWVNALLLFATLVWRGHWGRD-IPLLTRI 448 Sinorhizobium m...
P75932       371 APGFYSRQDIKTPVKIAIVTLILTQLMN----LAFIGPLKHAGLSLSIGLAACLNASLLYWQLRKQKIFTPQ-PGWMAFL 445 Escherichia coli
O83529       377 ISAFYAQHNSFAPMIAGTISFVTNIILA----TLLFIPLGGKGIAFSLSAASMVQTVFLWMFLKRSWQITIP-SLYKTSL 451 Treponema palli...
Q9WXU1       348 SRAYHASKEVKTPFFATLLVSAVNISLD----VILGFTMGASGIALATSVSYIAGFVFLTLRMKP---------SFDKKI 414 Thermotoga mari...
O51750       366 QKYYFSIRDAKTPFYLSVLFSILDIAIS----VFGINYYGLNALALAQSISFMICVIVFYFIILKRGVKIDL-IEILFVL 440 Borrelia burgdo...
O67658       359 KTVYYSKKNVEIPTKSAFLSVFLEALFG----SVFIFLLNFGVYSFPLAALISSSSVLVYLYQKLPQKVSIP-FGNLIKY 433 Aquifex aeolicu...
AAK80987     372 CRMFYALKDTRTPMINSAITVLVNVVLA----YYLKDVLRLGGIALASSIAAYVSSILLFIKLNSKLKNINY-RKTIGVT 446 Clostridium ace...
Q55179       385 VRVFYALGDGNSPFKVSLFNIFLNGLLD----YLFYKPFGTVGIVMATVGVNLFSMTIFIWMLNRRLAG-LSlGGWAMDL 459 Synechocystis s...
WP_010887143 416 LRTFYARERTREAVTVSAIGFVLEVGLY----RLLVPAFGLFGFGLSTTLSGILMAFALMLMYQRAL-GFPW-QAVGDHL 489 Deinococcus rad...
WP_002852456 370 SLWLYAKFKQKTAAWIAVKSLIISALCS----MAFIFLIKDESLKVIAVALSSSISAFYLLGANIK-----E-FGFKKFF 439 Campylobacter j...
CAB42720     740 ARLCiasvpAALIGGAACYAISR---SLGQG--VVGSLAALLAGGVLLFGVFFVAARRMRIEEVNSLVG 803 Streptomyces coelicolor A3(2)
P56882       449 PRLVi---aAAIMAAALYVAVDWlafPLSSAapLSTRALTLCGLIAAAMAIYFAVAFGIGGASLSMIRR 514 Sinorhizobium meliloti 1021
P75932       446 LRLVva--vLVMSGVLLGMLHIMpewSLGT---MPWRLLRLMAVVLAGIAAYFAALAVLGFKVKEFARR 509 Escherichia coli
O83529       452 YYGVkitlfSVIALVPTWASSFFtayFFPGShkIISHGVPLCVEALIFSCTGCILLLLSRDEFAYKALR 520 Treponema pallidum subsp. ...
Q9WXU1       415 FKISla---sAVMGTVILLLRG-----------SFKGNLGTIFLVLIGVFVYVLFSKLLKIEELEEILR 469 Thermotoga maritima MSB8
O51750       441 LKSIi----tLFPLYAIYFFFEKfqwDVGf---SFKNLYFLMAAGIVSIFVLFICYSVLGINKLFRYIR 502 Borrelia burgdorferi B31
O67658       434 LIAS------SFMGGLVYLTES-----------LTQNPFILVSFIPIYALFYYVFLIILREELAILISY 485 Aquifex aeolicus VF5
AAK80987     447 IKVIfasigMGIFLKVLYQIVG----QALLKkaIIIEIIGFGGITLIALLIYMLILYLMKVEEINMVSA 511 Clostridium acetobutylicum...
Q55179       460 GKLVg----VTAIASVAGWQGSVlwqRLWGVnsLVENILEVLTMSSIILVVFTVGVALAKVPEVDLLGD 524 Synechocystis sp. PCC 6803...
WP_010887143 490 ARVVplallSGIVAWLISRVM-----PAPGF--FLPGLFGLAVAGGAGLLVYLLGATLLKMPEMAGLLR 551 Deinococcus radiodurans
WP_002852456 440 ALIS--------IKICLLVIVA----------------LIVFTILLILIKPYILSFFIGIFTSFKGVF- 483 Campylobacter jejuni
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