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Membrane-anchored ion channel, Abi component RexB is a family of anti-lambda phage inner-membrane ion-channels with four transmembrane domains. On infection by phage, a phage protein-DNA complex is produced as a replication or recombination intermediate which activates RexA. RexA is an intracellular sensor that activates the membrane-anchored RexB. At least two RexA proteins are needed to activate one RexB protein. Activation opens the ion-channel leading to a drop in membrane potential, the outcome of which is the death of the host cell but also the cessation or abortion of the phage infection. RexA-RexB is one of the most well characterized bacterial abortive infection systems, or Abis. |
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