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Viral unique short region 10 This family contains US10 proteins found in HCMV Human cytomegalovirus. US10 is a unique short region trans-membrane glycoprotein found in the endoplasmic reticulum (ER). It down-regulates cell surface expression of HLA-G, but not that of classical class I MHC molecules. Despite of binding to classical class I MHC molecules and delaying their trafficking, it does not affect their steady-state cell surface levels. US10 contains a tri-leucine motif in the cytoplasmic tail which is responsible for down-regulation of HLA-G. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",