Conserved Protein Domain Family
HCV_NS4a

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pfam01006: HCV_NS4a 
Hepatitis C virus non-structural protein NS4a
NS4a forms an integral part of the NS3 serine protease, as it is required in a number of cases as a cofactor of cleavage. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex.
Statistics
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PSSM-Id: 366414
Aligned: 15 rows
Threshold Bit Score: 55.1611
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O56073   1597 GPVLLVGLAMAGGALlaHWTGSLVVVTTWSVNGGGnpllwatkrgvpiggPpiIPPPPPTge---gERFPGE 1665 Pegivirus A
Q56IH8   1523 GPILMVGLAIAGGMIyaSYTGSPVVVTDWDVKGGGnplyrs---gdqatpQpvVQVPPVDhrp-ggESAPSD 1590 GB virus C
O41892   1590 GPVLLVGLAMAGGALlaHWTGSIVVVTTWEVNGGGnpllyqtrrgvptsgSpvVVVPPCEg----gERYPCD 1657 Pegivirus A
O56074   1606 GPILLVGLALAGGAVlaHWTGSLVVVTSWRVNGNGnpliqqstrgvstsaPyqLTVCVEg------EQTPAD 1671 Pegivirus A
Q96898   1591 GPVLLVGLAMAGGAIlaHWTGSLVVVTSWVVNGNGnpliqsasrgvatsgP--YPVPPDGg-----ERYPSD 1655 Pegivirus A
CAL68576 1662 STWVLVGGVLAAVAAycLTVGSVCIIGRVVLSGKP------------------AVIPDREamyqqfDEMEEC 1715
Q68233     32 STWVLLGGVLAAVAAycLSVGCVVIVGHIELGGKP------------------ALVPDKEvlyqqyDEMEEC 85   Hepacivirus C
ABV46080 1658 STWVLVGGVLAALAAycLSTGCVVIVGRIVLSGKP------------------AIIPDREvlyqefDEMEEC 1711
Q7T7J1   1662 STWVLAGGVLAAVAAycLATGCVSIIGRIHLNDRA------------------VVAPDKEvlyeafDEMEEC 1715 Hepacivirus C
ABI36970 1660 STWVLVGGVLAALAAycLSVGCVVICGRVSTTGKP------------------VLIPDREvmyqqyDEMEEC 1713
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