Conserved Protein Domain Family
DUF316

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pfam03761: DUF316 
Chymotrypsin family Peptidase-S1
This is a family of trypsin-6 part of the chymotrypsin family S21, ie a serine peptidase. The C. elegans sequence UniProt:O01566 is trypsin-6: all the active site residues are present (His90, Asp168, Ser267).
Statistics
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PSSM-Id: 367641
Aligned: 9 rows
Threshold Bit Score: 297.029
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O76649         2 NIGILISLLFLGFSSSRIIGEKENQVLQSYCG-RTPFLQRRI---------INGKPLEAFENPWAVAAQFQYYVQKDGKP 71  Caenorhabditis ...
Q21628         5 SLTYIFVIINIGLVVGLNFTDAEVANLRASCKnKTLPPNNQQng-----htGVSLHGQNESYQWLVRVRLKDGTEGKDLY 79  Caenorhabditis ...
O45371         3 FLTLFIWIIACGFNNTQPLSYEENIQRLESCG-KILPEES-----------SNSITKSKYFKNWFGIAAFQNGNQYNFRT 70  Caenorhabditis ...
O62223         7 IIFYFIFVIAIIPIVTEKLSLKENKERLNTCGk------------------DKDIYNGIKNNRWHILAAFENGNNIEYIS 68  Caenorhabditis ...
XP_002635442   3 LLHLLPLVVFVVGVGAGKISEQENEQTQLICGkKADGYSRKV---------INGEYVKKGEHPWAVSVYTRYYDEKNESQ 73 
XP_002640478  15 ILIGIFSILIGSSEPFRKLSPDENQSRLKSCGnFKLPQHSQD---------ANGVIITKEPYELNNVVTFTACTIQQAFA 85 
O62231         5 VIVIFFALTGCIGCDFYKLTADENKDRASTCGkEVLERKG-----------NETTPANVSQTDWTLKMHNIDHNPDRYY- 72  Caenorhabditis ...
Q9XWZ8         4 QSIITISTFIIIVVSYNELTAEENDKRLETCGnEHIGKPSKN--------------SIISPVSWLTKLTRSEISA----- 64  Caenorhabditis ...
Q9U2W2         6 IGVLVFIGIVNCLISSQKLTVKENEERLKSCGnTFLPIPSINqtgkgfgffNDKTYTYNSKSGWLLLAGHKNRSTRVYA- 84  Caenorhabditis ...
O76649        72 krlvmvfPGTVISPYHILTYNLVRSYDGV---FGfqhKENMTSNGTCLGE--HYFLPEEYTDRFDIim--drSKFDMTRK 144 Caenorhabditis ...
Q21628        80 d-----sGGSFISTRHVMANSQSISTGKKkwaLNgadIGSSCNNDPVMGSlgIEEVPSDVVDKMEV------VIEKCQNS 148 Caenorhabditis ...
O45371        71 -------VGTFISKRHFLTLAYALMNSNMtwrA-----KHTKFRDSCVSGmeDSIVPPEVVADLKIfv---cPNGKGKHC 135 Caenorhabditis ...
O62223        69 -------SASLISNRHFITSAFSILNSQMewlMN----KEKLDYTACSKGalSLRIPMQFLRNLTIre---vSCQIWGSC 134 Caenorhabditis ...
XP_002635442  74 fi---ygPGTMISSRHIIKFNSLFYSTKN---LNlsgREYTGYKGICEGD--NLIVPQELLSRFDVdle-ylNDMNGNRE 144
XP_002640478  86 -------TATAISSRHILTSSHVFIDGRRk-------wRWTGQSVQCSAGsaDLDVPSEVLKSIDR-------------- 137
O62231        73 -------LATMISTRHVLTSARLVR-NESg--------wRDGSRDECDGK--NLVVPPSLLEKVEIpqhaqdGSKSVSNS 134 Caenorhabditis ...
Q9XWZ8        65 -------PAVIISPRHLITSSRLFL-TKSa-------wKNSGDSIDCDDSikHLEVPVNKLSDVIEpc---lSQKENCSP 126 Caenorhabditis ...
Q9U2W2        85 -------TAFPISEYHILISSRVMLTAEHkwiMN----GKPFDKNNCSGg-rHLDVPRDVLDNILF--------WYGKKP 144 Caenorhabditis ...
O76649       145 FQDLVRRVIVINGC---------PDVNSAKVLILELKKPle-lnPSIWPVCISNDPQL-FDRSSDFSVSGI------DAK 207 Caenorhabditis ...
Q21628       149 RTRNVTSAYVFNICana----hsKYKSHYAPMLVEIEGE-----PNEEYACLADTSTI-YKEGDKVHMYGIeyennaRSE 218 Caenorhabditis ...
O45371       136 PPSIPKKAWLHGICknn---ikkLFSSIHTPMLVEVETP-----IPGSSVCVPEKKTQiLEEPSFVYMFIP-------SN 200 Caenorhabditis ...
O62223       135 HSIRPVRAYLLNICtke---ienNFHRIYCPMLVEVENP-----IDSSIPCLVDNSIS-IQKDDAVDVCPLn-----PKS 200 Caenorhabditis ...
XP_002635442 145 FRNTIAKVTVINGC---------KQLLASNPMILELVAPl---eNSTVPVCISNSARN-WERVSGFSVYGL------NIT 205
XP_002640478 138 --LPLTRATIFDVCdptnkdfkyGTDISRSLMLAETNGT------FNDYFCLASEVTS-VHKDELLDSYGLaw---nKGT 205
O62231       135 TRCKITAAYILDGCas------sYPMLTAGPLIATIDYSs---qSNISVPCLAQEENL-MNVSEIGDLYFI------DDS 198 Caenorhabditis ...
Q9XWZ8       127 KVMNFARAYILNFCkst----lvQKRVYSFPMILELDENl---eGNSSYPCLADESIK-LAKGDAIDAYGC------TNN 192 Caenorhabditis ...
Q9U2W2       145 KKADISKARMFFACd--------NQDLKAYPVLIELNKTskrpwAFNGVPCLADETTS-SKLGDVVHSYGY-------TG 208 Caenorhabditis ...
O76649       208 GVLNSGLFKPVNCSVegp-fsCAEAVDNKQRMCAYDSGGSAIsnvSGQNTVLGVYVTGNMNCNANpqnltDFKFINIAN- 285 Caenorhabditis ...
Q21628       219 SEWKHRNDPIEDFYSew---iRTLKQGSDRPLAKGDRGGPLV---TDDGVLIGFGSTFALADNAE-----NHYFFDIKY- 286 Caenorhabditis ...
O45371       201 GSVVEKLVNITNS--------NWLEITTQLLGGIKEYCGSLIkkiHGKWTMIGLGTPKNVWKK-------HSFFFNLKR- 264 Caenorhabditis ...
O62223       201 RKRFTSPLNLEIV--------NIASLQTSGYSSEKKTGNPLTkwkNEKLIIIGNWATGDTTDSSR-----SNIFFNMKW- 266 Caenorhabditis ...
XP_002635442 206 GRLVSGRFRPIECSAsapfscAEASNKSSQGLCTGDYGGSAItkiNHRHVMLGFYASGNYECQGNtetmdPFKFVNLGH- 284
XP_002640478 206 YELYHRKLKFVGYGQ------APHSMFTEGYISKDEFASALVkekDGKNMLLGIGSANNQKSVRF-----DGHFFKIVD- 273
O62231       199 YKLKHSKTTINHTYS------LFYKTSIPTVFKSRHDYGILTnvvDNKMTVMAFAASDD-----------QNTFYTMSF- 260 Caenorhabditis ...
Q9XWZ8       193 SEWKHRKVNVGAGVS------PDILYGTVPNTEKGFDLGPLTkndSGRVWMVGFDLAATIGSRK------YPWYYKMSSa 260 Caenorhabditis ...
Q9U2W2       209 ESMQHRKLSITAV--------KDERICTDTYKTE-KAGGPLIlnvSGKATVIGLKAPASREN--------CELFYDLSK- 270 Caenorhabditis ...
O76649       286 HRESICKLTGIC 297 Caenorhabditis elegans
Q21628       287 LSSEICYLTNIC 298 Caenorhabditis elegans
O45371       265 FSGSFCHFAGIC 276 Caenorhabditis elegans
O62223       267 LVNEICDLIGVC 278 Caenorhabditis elegans
XP_002635442 285 YRKEICETTGVC 296
XP_002640478 274 FKDTICSLAGIC 285
O62231       261 LYKSLCEPTGIC 272 Caenorhabditis elegans
Q9XWZ8       261 MYPALCELAGIC 272 Caenorhabditis elegans
Q9U2W2       271 LQKEICDYSGVC 282 Caenorhabditis elegans
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