Conserved Protein Domain Family
Het-C

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pfam07217: Het-C 
Heterokaryon incompatibility protein Het-C
In filamentous fungi, het loci (for heterokaryon incompatibility) are believed to regulate self/nonself-recognition during vegetative growth. As filamentous fungi grow, hyphal fusion occurs within an individual colony to form a network. Hyphal fusion can occur also between different individuals to form a heterokaryon, in which genetically distinct nuclei occupy a common cytoplasm. However, heterokaryotic cells are viable only if the individuals involved have identical alleles at all het loci.
Statistics
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PSSM-Id: 399889
Aligned: 41 rows
Threshold Bit Score: 764.858
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4WZT4         12 LIVVAL-LLVLLPAQVHAFGAGNIASISAVEGKNWRHGDIEDMLKTIAF-----IKG----------------------- 62   Aspergillus f...
XP_009223898    8 PLIVGIlLLFAFAPGVAAFGAGNIASISKIEGQNWRHGDIEDALLKLVMas--aAGG----------------------- 62  
EHA47862        8 FWLIGIvLLVCWASPAYAFGAGNISSKSPIEGINWRHGDIEDALLGIIMaraldKKS----------------------- 64  
KLU85578        7 FLLAGLvLMVCLASPVLAFGAGNISSKSSIEGINWRHGDIEDALLGILMarglnKKG----------------------- 63  
XP_007704460    7 IWLPCLiLLVFWARPTAAFGAGNIASMSSIEGQNWRHGDIEDTLLTLLIs---gHTG----------------------- 60  
Q0U1X6         10 FWLPCLvLLVFWARPTAAFGAGNIASLSSVEGQNWRHGDIEDTLLTLLIs---sRTG----------------------- 63   Parastagonosp...
Q6BZS5          4 PILASLsGLAGLFTTAHAFGAGNIPSDSSIEGKNFRHGDIEDVLAGIVIs----HRGgk--------------------a 59   Yarrowia lipo...
EAU92260       11 FLIVAT--VCILLPRAHAFGAGDIPDFAYLNDKAFRHGDIESVLENLAK-----TAGraaigggnllafassvvsaatgp 83  
XP_007325739    8 FLLVFT-VLLVLTPSTYAFGAGDIPDFAYLNDKAFRHGDIEAILETLVK-----NVGssaagggllsf-atsvlesatgg 80  
CCA67339        8 LLVIAF-VLAVLPTSAHAFGAGNLPSYAYLEDKAFRHGDIEDVLAELLK-----RTGsgll----------------kqg 65  
Q4WZT4         63 HKWTSTMVKRVYFGNWLRDYSQAMDVGTLK-SLPADTIRILVWILSFLSFGYATAEFEVTSERLGVYRPEEHIDNPKDYA 141  Aspergillus f...
XP_009223898   63 NKFGKLDVSRVYFGNWLRDYSQAIDVGTVK-NVSAEAIRLLLCVLGFLTFGYGSREFEVTADRLGCYRPEDHIDNPKNYA 141 
EHA47862       65 KKFNKMAVMRVYFGNWLRDYSQAVDLGTIK-NVSYEAIRLVVAILAFMNFGFGSKEFEVTPERLGCYRPEEHIDSPKGYG 143 
KLU85578       64 KKFNKLMVSRVYFGNWLRDYSQAVDVGTIK-SVSYEAIRLVVAILAFMNFGLGSKEFEVTPERLGCYRPEEHIDNPKGYG 142 
XP_007704460   61 KKFSKMDVKRVYFGNWLRDYSQAVDVGTVK-MVSAEAIRILLWVLGFMSFGYGTKEFEVTRDRLGCYRPEEHIDNPKDYA 139 
Q0U1X6         64 KKFSKMDVKRVYFGNWLRDYSQAVDVGTVK-MVSAEAIRILLWVLGFMSFGYGTKEFEVTRDRLGCYRPEEHIDNPKDYA 142  Parastagonosp...
Q6BZS5         60 RKFDGLDIKRVYFGNWLRDFSQAVDVGTLSmGLNADTVRAIIWLVSMSEFGYGTGEFEVTEERLGVYRAEEHMDNPKGYP 139  Yarrowia lipo...
EAU92260       84 RKFNKNDIKKVYFGNWLRDYSQCMDIAGLS-KLSAETLVLVVSVLGFMTFGFSTEEFEVTAERLGVYLPVEHIDNPKGYA 162 
XP_007325739   81 AKFNKMDIKRVYFGNWLRDYSQAMDIAGLS-KLTADTITLIVSILGFMTFGYATEEFEVTQERLGVYLPVEHIDNPRGYA 159 
CCA67339       66 SKFKGLDIKRVYFGNWLRDYSQAVDVAGLK-ATTIQNIITICTVLGFMAHGFVTDEFEVTEERLGVYLPVEHIDNPKGYP 144 
Q4WZT4        142 DNQ-DARQYDSRLRGPIRQ-VELEIDPQTGMKNYIANERGDWATSTAYIKYSLARSIHYGRLYTSGGH-HKGKEEDLCEA 218  Aspergillus f...
XP_009223898  142 DNQ-DATRYDRRLRGPVDEsVELAVDEETGLKNYIANERAGIMTSAQHVRNLFGRCIELGRSYg-----RNRNKAELYEA 215 
EHA47862      144 GGD-NPKRYWEGLRGPVDEeRELTVDPDSGMKNYIANERAGIDTSAGLLRNLLGRCIDLGRAHa-----RSGRDEDLYES 217 
KLU85578      143 GGE-DAQEYWHGLRGPVDEeLELAIDEETGMKNYIGNERVGIANSASLLRHLLGECIERGRRHg-----RDGNEEDLYEC 216 
XP_007704460  140 DNI-DARDYDRRLRAPVDErRELSIDEKTGLKNYIASEELGITTSAGMVRDLLARCIDLGQR-------SGGRGPDFYEA 211 
Q0U1X6        143 DNL-DAREYDRRLRAPVDErRELSVDERTGLKNYIASEDLGITTSAGMVRDLLRRCIDLGRR-------SGGRGPDFHEA 214  Parastagonosp...
Q6BZS5        140 E---DAQQYDRRLRGPVDP-RELEIDPKTGMKNYIANEDGDWATSSEYVREQLLRCIKLGRRYIKGGYkKHSLQ---HES 212  Yarrowia lipo...
EAU92260      163 EKEgDAREYHPKLRPPVDP-RELEIDPETGMKNYMATEGQGWDTSTGFIRRTLRECIEYGRRa------NGEENADLWEA 235 
XP_007325739  160 EKEgDARQINSNLRPPVDP-RELEIDERTGMKNYMASDNQGWDTSTAFIRRTLKACIEHGRRa------GGQENGDLFEA 232 
CCA67339      145 D---DARKYHPKLRGPVDP-RELEIDLRTGMKNYIANEDGGWDTSRALVRRRLQECINIGRRYr-----STHNKADQYEA 215 
Q4WZT4        219 LRCLGQGLHTLEDFAAHTNYCELALREMGFRNVFPHTGAATEMNI-RGHR--VFPLVTGTFGMVDFFHSVLGEATDHFTQ 295  Aspergillus f...
XP_009223898  216 LRLLGTGLHCLEDYFAHSNYAELALIEMGERDVFPHVGRNTQLRI-PGARhsVYPAVTGTFGGVDFLHSVTGEVSDKLTQ 294 
EHA47862      218 MRLMGTAMHCLEDFFAHSNYVELALIEMGHRDVFPHVGRDTKLRI-PGSRgeVYPIVTGTFGEVDFLHSVAGEVSDKIKQ 296 
KLU85578      217 LRLMGTALHCLEDFFAHSNYVELALIEMGEREVFPHVGRDTRLRL-PGARrrVYPVVTGTFGEVDFLHSVAGEVSDKLMQ 295 
XP_007704460  212 LRLLGTATHCLEDYAAHSNYVELALIELGEHAVFPHVGKNARFYV-AEAKkeVYPIVTGTFGGVDFLHSVCGEITDKTTQ 290 
Q0U1X6        215 LRLLGTATHCLEDYSAHSNYTELVLIELGERDIFPHVGRNAQFEI-QAARkqVYPIITGTFGGVDFLHSVCGELSDKATQ 293  Parastagonosp...
Q6BZS5        213 LRLLGSALHTLEDFTAHTNYLELVLRDMGYKDVYAHVGNQTRIKL-AGKK--VFPVVTGTFGGLDFLHSLLGGAHDSLSE 289  Yarrowia lipo...
EAU92260      236 YRLLGTGLHTLEDLMAHSNWCELALRKMGYEEVFCHVGDNVLVDTpNGP---APPLVTGTFGGADFLHSLLGEAGDKLSQ 312 
XP_007325739  233 YRLLGTGLHTLEDLLAHSNWCEIALRKMGHEEVFCHVGDNVIVETpNGP---CPPLVTGTFGGADFLHSVLGEAGDHLSQ 309 
CCA67339      216 FRLLGSALHTMEDFPAHSNFCELALVSMGCNQVFTHVGDNVRIPApNGKF--VAPLVTGTFGGDDFQHSLLGEAGDHISQ 293 
Q4WZT4        296 SEVNEMDIALGDAQANS---SGGSLSAFTGLLGKIP---------------GTKD-LIAEAEELKRRSDAQQYANQHggq 356  Aspergillus f...
XP_009223898  295 NEIQELEATLDNNKRND-------NSGLKDLLDKLPpgl-------------igGdKKDRLDEIQENNAAAQMEQM---- 350 
EHA47862      297 NELQELEELLQDNKKND-------TSLLKNLFKMLPdsl------------fgGEsQSSKMDQIEQDCTQAQMNNL---- 353 
KLU85578      296 NEMQELQAHLEDNQNQK-----SDTSLLRTLLDMIPdgl------------fgGEhQSDKMSEIQQNCTNAQMEGL---- 354 
XP_007704460  291 SELQELEGAISNADRSK------NKSKIKELLEKLPegi------------fgGKdESSKADELENNANAAVMGNM---- 348 
Q0U1X6        294 SELQELEGAISDADRKK------NKSQIKDLLSQLPdgi------------fgGKdQGGKADELENNASAAAMGNM---- 351  Parastagonosp...
Q6BZS5        290 SGFTEASANFEKKKKSG----SNTSEFLKSILRKLPiklpdipdahggfrdMTGAdLADHLDELQHNVEEYVVHQREhdg 365  Yarrowia lipo...
EAU92260      313 ASVTDLSGKLNEAQQSG----GADLGPLKNILSRIMgg------------sSEEEeKLNQGEEMKEAAQGY--------- 367 
XP_007325739  310 ASVTELTSKMNEASQGE----ESNISAFKDIIGKLPm--------------GGNDdKVNQGDQMQQQSKAY--------- 362 
CCA67339      294 SSISDLNEHVNKARAKSasgDFGSANKIKALIATIP---------------------SPEAQSMSRDIDTMQANRAt--- 349 
Q4WZT4        357 rtgyahetsrgldsygsavgrdlgeslsrasgpsqpstSGGPAGPGLPGM-P----------------------DFDPKK 413  Aspergillus f...
XP_009223898  351 ------------------------------------------------NVsP-----------------------REPEE 359 
EHA47862      354 ------------------------------------------------EVrP----------------------HREPEE 363 
KLU85578      355 ------------------------------------------------DVrP----------------------HREPEE 364 
XP_007704460  349 ------------------------------------------------RItP-----------------------KDPEE 357 
Q0U1X6        352 ------------------------------------------------HVtP-----------------------KEPEA 360  Parastagonosp...
Q6BZS5        366 ndedckd----------------------cgdtkkksrTGGSGGNAQQGQhPlvlvdqppfkntpggtniskvhNNDPNY 423  Yarrowia lipo...
EAU92260      368 --------------------------------------------------------------------------HFDPDN 373 
XP_007325739  363 --------------------------------------------------------------------------NFDPND 368 
CCA67339      350 ---------------------------------------------------P----------------------GKDPNT 356 
Q4WZT4        414 --------------TVAQIYPILQFRDNVVRKLSSII---EKIPGLEALVEKVTETLTIFVMSLLAPFIRPIINAASNSL 476  Aspergillus f...
XP_009223898  360 ftrq-------vqqVFGQIMPVIEFHDEIFQNISQAL---ENIPILPQILEQFQEQMSMWVFTQIAPFVLPIIRQIKNEL 429 
EHA47862      364 itkw-------vsnIFKQIIPVIEWHDRIMKIISDAL---PSIPVIPKIIEQLEDQLNAFVMMQLAPFIVPVLQQIQNEM 433 
KLU85578      365 mtiw-------vgnIFRQVVPIIEWHDRIMKAISDAL---PTIPVIPKIIEQLEDQLNAFVHAQIAPFVVPVLKQIQNEM 434 
XP_007704460  358 ftqq-------igeLVKQIYPIMEFHDEIMQSISEFI---EKIPILPDLIEEVQNQVTIFVFSLLAPYVLPILSQVKTEL 427 
Q0U1X6        361 fteq-------lgeLVKQIYPIMEFHDEIMMSISEFI---EKIPILPEIIEQVQEQVTVFVFSLLAPYVLPIISQVKAEL 430  Parastagonosp...
Q6BZS5        424 tslesyldnldvdaVIRAVYPLLEFKDSVMSSLESFFgdsDSSTALGMMASSISDALSSFTNSIINPIINPILEAVTEIL 503  Yarrowia lipo...
EAU92260      374 iap---------peVQQKLLDLLKWHDDVMRNVTKKM---AMVPGLNNLLEEFSNALNGYIYTVLAPYLTPILAQATSVL 441 
XP_007325739  369 iap---------peVQRNLIDVLKWRDSIVKDITQKM---DMVPGLSDLIDELTNALNAYVYTILAPYVVPLITSATGIL 436 
CCA67339      357 mtp---------keLYQNIWAILSFRDSVVKKMSYGI---EKIPGLGPLIDSIMENLTVFVIQTLEPYLKPLMKTATTQL 424 
Q4WZT4        477 QAGSSSVIDASGKHQFEPWTNPHCTDPTHSMLSKDHFSNILNEPAGRVASAILKYVAPRVLYAWEHPEVPEQQVLDDCLC 556  Aspergillus f...
XP_009223898  430 KTGSSEIIESSKNEQHIVFEDDNSTDPTHSMLSKDHFTNILNEVAGKTAKKVVEWVVPQIMQAWDDHNMDVGRLMNRIIS 509 
EHA47862      434 NAGSNGIVESSKRDQFVVFDDDRSADPTHSMLSKDHFTNLLNEPAGKTAAEMVKWVVPQIMQAMDDESIDIGRTVNRIIY 513 
KLU85578      435 GAGSEGIIESSKHNQHNVFENDEETNPTHSMLSKDHFTNLLNEPAGKTAAEMVKWAVPHLMEAIDNEDVDITRTLDCIIS 514 
XP_007704460  428 EEGSTEVIASSRDKQHIVFNDDDCTDPTHSMLSKDHFSNVLNEPAGRVASATIAWAVPQIVQCWDGQA-DPTQTIDTIIE 506 
Q0U1X6        431 ETGSSEVIASSREKQHIVFNDDYSTDPTHSMLSKDHFSNILNEPAGRVASAVLTWAVPQIVQCWDGQG-DPEETISRIID 509  Parastagonosp...
Q6BZS5        504 H--ASVTLLSYHDDQIDVWINSKSTDPTHSRLSKDHFAAYLNEPAGLVAAEVVKYVVPFVVEAWEDPSIDPQTVVDEALQ 581  Yarrowia lipo...
EAU92260      442 DEGSKAVIDSE--DQYEVFDNPDAHDPSHSLLSKDHFGLILNEPAGKIAQIIVEHTVNHIVQAWYNDE-DPDSVLNVILE 518 
XP_007325739  437 DEGSKEVINNS--DQYQVFDDPDASDPSHSILSKDHFALILNEPAGKIAQVIDEYAVNLIVRAWSDDS-DPDSVLDAILE 513 
CCA67339      425 AASSAAVINKL--DQYEVFHDPNASDPTHSILSKDHFNLILNEPAGNLAKIIVIHTVKLVVHAWDHAEDNIHHVTETILE 502 
Q4WZT4        557 -VFHHPAL-RDMHN-----EAHRTMFEAVQNWAHSRPDRGAs-LNDILSSEGVRAGKNNGGE 610  Aspergillus fumigatus
XP_009223898  510 gVLHHPAQ-RDQGRdg-aeEGRSIIFRSVEEWWNGMDEGAKdeYRRKLSREGVENGQNHKEG 569 
EHA47862      514 gVLHHPAQ-RSLGHdg-anEGREIFFRSIEQWWGCMGPDQQrdYLRRLSRDGVRNHENHKEG 573 
KLU85578      515 gVFHHPCQ-RDMGGag-aaEARTIFFSCVEAWWNEMDPEKQddYRRRLSRDGVRNHENHKEG 574 
XP_007704460  507 gVFHHPAC-VDMEPktkmmEGRAIMFNTVSKWWDSKDDDAKveFRKQLSREGVRNGKNHKEN 567 
Q0U1X6        510 gVFHHPAV-PQGRVrg-seQCRSIMFQTVEKWWRAQPD--QddLRRKLSRRGVQNGENHKPG 567  Parastagonospora nodorum SN15
Q6BZS5        582 -TFHHPALaHT--------KLHRIMRAEVDRWIQTFSDEERehILEGLTSRGVLHGHNNAEH 634  Yarrowia lipolytica
EAU92260      519 -AFHHPYY-NTGNS-----EVQHKMFEHMQKWIGGLGPDEAaqTIEALTKESVREHKNKRLG 573 
XP_007325739  514 -AFHHPYY-ATGSS-----QIQNKMFEHMEMWFGGLGSEVAsqVIQRLTKESVREHNNKRIG 568 
CCA67339      503 -CMFHPDF-HNPRS-----SVQKEMMEFMRQWLSTHSAGHHd-VLSRLTKEAIRNHQNVRKQ 556 
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