2WJV,2XZL


Conserved Protein Domain Family
UPF1_Zn_bind
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pfam09416: UPF1_Zn_bind 
RNA helicase (UPF2 interacting domain)
UPF1 is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD).
Links
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Statistics
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PSSM-Id: 401391
Aligned: 46 rows
Threshold Bit Score: 190.537
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2WJV_A         7 HACSYCGIHDPACVVYCNTSKKWFCNGRGNT-SGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPA 85  
A0C1B9        30 llfSYCLQSDVNAVAQCLTCKRWYCNS--ATkSGSHIILHLIKNKHSQISLHSKNKVEITTIECYGCEQKNLFTLGQVNG 107  Paramecium tet...
EAY17561      46 pCCSYCLCDIPECLVKDKAIGRWFCNGRGKA-LHSHIIHHLVKSRHMEIELPPQNPYSQIPMTCYLCHSTNIFRLSFVQS 124 
XP_001323558   5 pKCQYCGCEAEGSLAQCAATGLYFCNGKGDT-LQSHLVHYLRTCHLDKIILPKCNPFSGISLKCYVCGSENVFRLGFIHS 83  
Q582F1        28 pSCSYCSEESPTCLAFCNGCSKWFCNGSNGT-SGSHIILHLVKSGHNSLKLHAENSLGDSTLECYICRSSNIFSLGFMPS 106  Trypanosoma br...
CCC67331      70 HACAYCGVDSPTCVIKCNSCNKWFCNSKNGT-NSSHIVNHLVLSHHNVVSLHPDSDLGDTILECYNCGCKNVFLLGFVSA 148 
XP_002619682  89 EACSYCSTSDPASLARCGTCQRWFCNGSSSK-AGSHIVAHLVHSKHSEISLHEQSALGGDPLECYNCGSRNVFALGFVAA 167 
XP_013932413  16 dACAYCGISEPDSLVKCNTCEKWFCNGKTSG-AGSHIITHTVLSKHQSLSLHPDSELGDTMLECYNCGNRNIFVLGFVSA 94  
XP_002492883  55 HACKYCGVSNPRCVVRCDICKKWFCNGKSGT-T-SHIISHMVLSRHHEVSLHSDSDLGETELECYSCGNKDPFMLGFVSA 132 
2XZL_A        12 nSCAYCGIDSAKCVIKCNSCKKWFCNTKNGT-SSSHIVNHLVLSHHNVVSLHPDSDLGDTVLECYNCGRKNVFLLGFVSA 90  

2WJV_A        86 KADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLR-AR--QITAQQINKLEELWKEN 158 
A0C1B9       108 TNKENILILCRG-CLPLRQLGEITWDSNDYQPLIKDKSIQEWLL---GQGDKIN-SR--MVTLERINQYEEERKKk 176  Paramecium tetraur...
EAY17561     125 QKTGKYFVLCRE-CCNDPQLHLYSLDLAHRQLIVQQTQMLEWLVRPPSHAESKDgFRfcDITPTDMDLLEETWPKN 199 
XP_001323558  84 -SNQQIFLACRSPCQFHESLISRGVDNSTFQPLISNGDVIHDVIPPPLQDQY---AKipLVKAIQICesvkrtlag 155 
Q582F1       107 KEEAVVVLVCREPCLHSKTLRDLNWDSSTWLPLIEERRLLPWICSIPSTL-----RR--PLTLHDIKALEMSWEQk 175  Trypanosoma brucei
CCC67331     149 KSEAVVVLLCRMPCAQTK---NVNWDTDQWQPLIEDRQFLSWVAEEPSEEEKLK-AR--LITPSQISKLEAKWRSN 218 
XP_002619682 168 KQESVVVLLCRMPCAQAR---DINWATNEWQPLVEARALLPWVAA------QREpAR--DVKPAQMARLEAQWRvk 232 
XP_013932413  95 KTDSVVVILCRLPCAQSK---NVEWNTANWQSLIEDRALLPWVAKPPSEEEKLE-AQ--PITSLQITKLETKWKQD 164 
XP_002492883 133 KTDTIVVILCRIPCSQAK---DSDWNTANWQPLVEERCFLDWIADYPTPLDMAN-AR--AISPLDISKLERQWRSD 202 
2XZL_A        91 KSEAVVVLLCRIPCAQ---TKNANWDTDQWQPLIEDRQLLSWVAEQPTEEEKLK-AR--LITPSQISKLEAKWRSN 160
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