Conserved Protein Domain Family
SNF5

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pfam04855: SNF5 
SNF5 / SMARCB1 / INI1
SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).
Statistics
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PSSM-Id: 428158
Aligned: 92 rows
Threshold Bit Score: 183.549
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCA69189      881 SKQEMLVPVRIDVDIgDgY-------NRLRDTFVWNANDPYVTPTVFAQTLCDDFAIGfglgqasESArrkFIDQVVSSI 953 
EED80298      172 RRPTSLVPIRVEFET-D-T-------LRIRDCFVWNLHEDLIKPESFARAFCVDLDLP-------VNP---WAETVANQI 232 
EKM51678      278 RKPVALIPIRVEFET-D-A-------HRIRDCFVWNLHEDLIPPEVFARTFVQDLDLP-------EHP---WVELVANQI 338 
EMD39783      283 KKSTALVPIRVEFET-D-T-------HRIRDCFVWNLHENLIKPEAFARTFCADLDLP-------VNP---WAELVANQI 343 
EPT02261      248 RKPTALVPIRVEFET-D-T-------HRIRDCFVWNVHEDLIKPESFARTFCADLDLP-------ANP---WADLVAAQI 308 
XP_001875852  160 QRRSSLVPIRIEFET-D-T-------YRVRDCFVWNLNETIIKPETFARILCNDLDLS-------PNQ---WADTVANQI 220 
XP_001835907  260 QKRASLVPIRVEFET-E-T-------HRIRDCFAWNINEDLIKPETFARIFCNDLDLP-------LIP---WAETVANQI 320 
XP_007329948  275 SKRTSLIPIRVEFET-D-T-------HRIRDCFVWNVNEELIKPETFARIFCYDLDLP-------LT----FVETVAAQI 334 
EKD00182      245 GRAEALVPISIDYDI-P-DpngegkgLKIKDRFLWNASEPFVKPLEFATIFCHDVGIH--------EN---NAATIAELI 311 
XP_007417258  273 EDR--LVPIRIEFDT-E-E-------IRVRDVFTWNLSEKRISPETFAIEFCHDLDIS-------PVQ---YVPKIIEQI 331 
CCA69189      954 HEQITDYknhrveieANTTKPSTaavppstsgtplpihskpistiggltvnglgreasrsrsatplpgereksekpisai 1033
EED80298      233 RAQLEEH--------EGVAAVDFgvpdpemee------------------------------------------------ 256 
EKM51678      339 RAQLEEH--------EGVGSMDFdvanpfg-------------------------------------------------- 360 
EMD39783      344 RAQLEEH--------EGVASLDLgadyhmdvdg----------------------------------------------- 368 
EPT02261      309 RAQLEEH--------EGIAALDLgteadied------------------------------------------------- 331 
XP_001875852  221 RAQLEEH--------EGVASMELgldgavdid------------------------------------------------ 244 
XP_001835907  321 KAQIEEY--------QDVASMEIgmdsalspe------------------------------------------------ 344 
XP_007329948  335 RAQIEEY--------EGVASMELgqdgapdfd------------------------------------------------ 358 
EKD00182      312 MSQVEEQ--------QNAVAIDLatrdvtpddvv---------------------------------------------- 337 
XP_007417258  332 NFQLKEF--------STISNLKLlpnqteld------------------------------------------------- 354 
CCA69189     1034 kkrasfvdsgigkkrhrpAndgpsgvgkfeeedevqwwerwrkrmraldgsavrksskakvagvgkagrsskpalrvggr 1113
EED80298          --------------------------------------------------------------------------------     
EKM51678          --------------------------------------------------------------------------------     
EMD39783          --------------------------------------------------------------------------------     
EPT02261          --------------------------------------------------------------------------------     
XP_001875852      --------------------------------------------------------------------------------     
XP_001835907      --------------------------------------------------------------------------------     
XP_007329948      --------------------------------------------------------------------------------     
EKD00182          --------------------------------------------------------------------------------     
XP_007417258  355 ----------qmkleeleGi------------------------------------------------------------ 364 
CCA69189     1114 kskaslangsssksvkieaeevdlkvpivsepdeyqrelifvddeekepadNINEDLRILIKLDIAFGVRRLEDQFEWDI 1193
EED80298      257 ----------------------------------------------klrageemGECRVILSIDVQIATYHLCDTIEWDL 290 
EKM51678      361 ------------------------------------------------pgedevPECRVILSIDVQIATYHLLDHIEWDL 392 
EMD39783      369 --------------------------------------------dsdntsveeiPECRVILSIDVQIAGYHLVDHIEWDL 404 
EPT02261      332 ----------------------------------------------etseggevPECRVILSIDVQIANHHLSDHIEWDL 365 
XP_001875852  245 ---------------------------------------------appthgeeiAECRVILSIDVQIANHHLMDHIEWDL 279 
XP_001835907  345 ---------------------------------------------emaepgdelPECRVIVSIDVQIANHHLLDHIEWDL 379 
XP_007329948  359 ---------------------------------------------nngqssdeiPECRVILSIDVQIANHHLMDHIEWDL 393 
EKD00182      338 ----------------------------------------fsddespaddeYPEPDCRIIVNLDLQIFQHVLRDRIEWDL 377 
XP_007417258  365 -----------------------------------------------------ePDLRVIINLDVQIQTLHLVDKIEWDL 391 
CCA69189     1194 SDKRnSPEQFAEVYCVDLGLSGEFKTAIAHSIREQVQVYEKSLYlvghpmdgttiqdedlrla----------------- 1256
EED80298      291 LSSL-TPEAFASKLCSELGLSGEAVPLVAHAMHEEIVKHKRDALewgviggdareadderprdksglsllkdktg----- 364 
EKM51678      393 LSPL-TPEQFASQLCADLGLAGEAVPLVAHAIHEELIKHKRDAIewgivgvdphpsahddpdrprdrsglsllkdkt--- 468 
EMD39783      405 LSPL-TPEAFATTLCAELGLAGEAVPLIAHAVHEELVKHKRDAVewgvigvetreadepaadrprdksglsllkdkt--- 480 
EPT02261      366 LSPL-TPEQFAGTLCAELGLAGEAVPLIAHAVHEELLKHKRDAWewgvlgieqqhaadedrprdrsgasllkdktg---- 440 
XP_001875852  280 LSPL-TPEAFSQKLCTELGLSGEAVPLIAHAVHEELIKHKKDAIewgviggdrepaddgsgvrdrsgagmlkdktg---- 354 
XP_001835907  380 LSPL-TPEEFARGLCADLGLTGEAAPLIAHAVHEELVKHKRDAVewgviggptahdgkeatpalgepaqpekrdrsgysl 458 
XP_007329948  394 LSSL-TPEAFAQNLCWGLGLSGEAVPLVAHAVHEELMKHKKDAIewgviggereigddagardrsgfglvkdktg----- 467 
EKD00182      378 SSPL-PPAEFARHYCAELGLTGEAVPIVAHAIHEELIKHKRDALemdlfaqthpgeqakwertggqpk------------ 444 
XP_007417258  392 ASNL-TPELFTKQYISELSLPTSSLPIISHCIHEEIFKYKKECVsiglisknylhsrkhqahqnqrfessdp-------- 462 
CCA69189     1257 -------------------flpslascirpmdqiaayTPQLGFFNEVDLEKT 1289
EED80298      365 ------lglgwgrapkdgrgpkplrsvwrdwaeaeefTTRFEVLTAEEVERR 410 
EKM51678      469 -----glglgwgrtpkdgrgpkslrsvwrdwaeteefKTRFEVLTPEEVERR 515 
EMD39783      481 -----glglgwgrapkdgrgpkslksvwrdwaeaeefRTRFEVLTQEEVERR 527 
EPT02261      441 ------lglawgrapkdgrgpkalrsvwrdwqeaeefRTRFEVLTAEEVERR 486 
XP_001875852  355 ------lglgwgraprdgrgpktlksvwrdwaeaeefRTTFEELTAEEVERR 400 
XP_001835907  459 lkdktglglgwgraprdgrgpkvlrsvwrdwqeaeefSTSFDLLTAEDLEKR 510 
XP_007329948  468 ------lglgwgrapkdgrgpktlrsvwrdwqeadefRTKFEELTAEEVERR 513 
EKD00182      445 --------------tnsrtgakglvgvwrdwwerdefSPLLFEISHDDMVKR 482 
XP_007417258  463 ---------llrerfslqkgcrrlegvwrdwnecnlfGPKLEYLNGEDLEWI 505 
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