Conserved Protein Domain Family
Transglut_i_TM

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pfam14400: Transglut_i_TM 
Inactive transglutaminase fused to 7 transmembrane helices
A family of inactive transglutaminases fused to seven transmembrane helices. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighbourhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it.
Statistics
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PSSM-Id: 433934
Aligned: 47 rows
Threshold Bit Score: 137.361
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:DaAHT2_0348     25 RHLQTGIPLLPGEQAPVWLVEARVDFNADGG--------AVTVNLDIPDDPPGFFLLAEQTASPGYGF---------SIL 87 
jgi:Riv7116_0423    25 KVFATDVPLLPNQAYQNWYVEAKLSVNSEGRvldsenalPSEIELQLPQTSPGYKIISEDFINDSYTR---------QVK 95 
CCK80711            24 KYHFLNFPLKPDKTSNLWNIEIRLSFDADDR--------PLKASLFLPVESDNFIINSEYFVSGKYGL---------VTE 86 
jgi:Desal_2812      24 KAFVLGFPLTPEEQTEIWNVEAHVSFEAEGS--------PVKATLQTLNRLPQYTVTDEYYIGDDYGLlhalqsadgTPQ 95 
WP_025384672        26 RHFILDVPLTETESVNSWMVEANLRFIAEKNr-------PVKASFTIPYMPPNFTILDEYFVSQNYGV---------TTN 89  Legionell...
Q88KF9              26 QIFVLGIPVTEDETDDLWNIDAKVEFVASSKd-------PVKVQMFVPPLNRDYVSLNESFISNNYGV---------SIN 89  Pseudomon...
Q0VM83              26 QLLVQNVPLSQDEKDPVWVVDSQVSFVAKANk-------PVKVRMFVPPLGAGYTTLNESFISNNYGV---------NVN 89  Alcanivor...
zhongguo:B5T_00617  23 QILIQKVPVTESETDPVWVVDAQVQFQARGNh-------PVKVRMFVPPLDSGFTTLNESFISNNYGV---------NVS 86 
jgi:Nit79A3_3074    25 KHFALGFPLSPDDKKSVWTIEAKIDFIARGD--------PVIVSFALPPQTPNVVFMEEDFASPGYGF---------SEL 87 
WP_013044397        25 KHFKHGYPLLPRQQTPVWSIEANIRFKAKGD--------PVKLNFAVPGEQATFGILDESGSSQGYGF---------TPA 87  Coralioma...
jgi:DaAHT2_0348     88 EDN--GN---RRGEWTIRRASGPQTMYYKIQLVPwggqmaspagAEERRAATRASv---PEPVDVF-------------- 145
jgi:Riv7116_0423    96 ELKnsSN---RVAVFSNKNAKGSEAIFYRAIIDK----------TDLAKNNSKSD----SEPVSITgekfveqqlsnfdk 158
CCK80711            87 KKN--GN---RKAIWSIRNAKGRQHLYYRVFIQKtg-------gKGQSSHRQLIP----AKISVPS-------------- 136
jgi:Desal_2812      96 QTRnpDN---IVAIWSRRSAKGKQDLFYSARLRP----------KHSNVEESWVHpteiPKLSDPH-------------- 148
WP_025384672        90 LSG--YN---RRVVWSLRRGNGPQSLYYRTILRE----------TGNMETHLSKPiamlPKTEILP-------------- 140 Legionell...
Q88KF9              90 RAD--GN---RKVTWSARRASGNQTLYYRLVLTKrysn--ektkVKGPTFRDSLA------------------------- 137 Pseudomon...
Q0VM83              90 VDK--GN---RQVTWSSRRAEGNQYLYYRLMLTPryad--vpekDPGPQFRPAPT------------------------- 137 Alcanivor...
zhongguo:B5T_00617  87 REG--GN---RLVTWSSRRVEGRQSLYYRLLITPrfaepggqakEPGPQFRPSPT------------------------- 136
jgi:Nit79A3_3074    88 ASP--TG---RRAQWSKRTASGPQTAYYRLSMYE----------TDQFIQPPIAAadlpAEPEKPE-------------- 138
WP_013044397        88 KKQdaSEdfyRTVTWSRDQAKGTQELYYRTDIYK----------RPSLKNLKLQSp---PTTPDPQ-------------- 140 Coralioma...
jgi:DaAHT2_0348    146 ------------WE-EAEAVAARQLLAVARERSSTPESLTRELIKLLAAAEPDQNAALLLASS 195
jgi:Riv7116_0423   159 dnavvednlkenFP----VAEIESIFREARDSNNNTLDFAKQIYQLALNP-DDIRIRTIQRTL 216
CCK80711           137 ------------LQ-DPYLSAAKRLWNEIYKHSADLDTIIGNLFKRLNQPDADEDVALLLGEN 186
jgi:Desal_2812     149 ------------FT-EAEQVAANSLITEVGSESADIDTFVPQLMKRLMEPSSNLDAAYLLRDT 198
WP_025384672       141 ---------------ENQKTAIDTIIDKARQSSADIQTFAQSAVKELNK--KDGNAKLLVGNE 186 Legionella oakridgensis
Q88KF9             138 ------------VE-GPEKIAAEALMAPIRQHSADVETFVSETIKRVNNL-NDDNVKLLLAGD 186 Pseudomonas putida KT2440
Q0VM83             138 ------------LD-GPEKLAADALLEPIRQHSADVETFISETIKRVNEL-ENDNVQLLLGSD 186 Alcanivorax borkumensis SK2
zhongguo:B5T_00617 137 ------------LS-GAEKVAADALLAPIRQHSADIETFISETIKRVNSRDDNDNVRLLLGGN 186
jgi:Nit79A3_3074   139 ------------FD-GVLKTAAITLLDQVRSKSANTEIFTRELIRTLNSNTPDQNQRLLLNDQ 188
WP_013044397       141 ------------YQeGPLAISASEIIEQAKRASADSITFVSQLIQLLANP-GDQNAQTLLRVA 190 Coraliomargarita akajimensis
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