Conserved Protein Domain Family
sCache_2
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pfam17200: sCache_2 
Single Cache domain 2
This entry represents the single Cache domain 2 (sCache_2), which contains the long N-terminal helix domain. This domain recognizes pyruvate, acetate, propionate, glycolate, L-lactate, acetoacetate, urea and hydroxyurea, acetamide, formamide, L-malate and citromalate, malonate, methyl and bromosuccinate and citraconic acid (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Links
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Statistics
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PSSM-Id: 435780
Aligned: 22 rows
Threshold Bit Score: 128.24
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
jgi:Bsel_2623   37 AKEESEDHLRSITEGAMGVVEAAYSLVESGLKTEEEAQEFVKETLLGPMQEDGtrdfsgsqflygdQGYPIVWSDDYIAE 116
jgi:Dacet_1646  45 MMDAKRAEVKNYMDVALTSIKRVYD---DPVISEQEKKERVSTIIRDLRYGS--------------DGYYFMYTYEGKNI 107
jgi:DvMF_0616   47 AETYRRSHLREMVLLARNQVQPVLDELAAGAYGRDHALVLVRERVRTMIFNDTh-----------gPNYIFMSGYDGTVL 115
ACL02209        48 IESQRLDQMKQLVEIARNAVEPIAARCRSGDISREAGIAEIRNLVRRMTFTESh-----------gNNYVFMSAYDGTML 116
WP_003413691    48 MRYDYDNQIKNQVDGAITVIKGVYRDYENGKYTEEEAKLLAANLVRQMRYGE--------------NGYFWIDTYDGNNV 113 Clostridium b...
jgi:Desru_1593  49 SHQRYDMNIKIAVENLVSMLEANYQRYENGEITEQEARKNAEIIVRDTRYNGG-------------SGYFWADTSTGLCA 115
WP_011759767    40 LEQQKWLQNDGQLDTVLSLVEVHRQQVQQGQISEADAKAEVASLINAAHYGN--------------GGYFMVVDAEGQIL 105 Shewanella am...
jgi:Spea_1997   40 LIAQKWLQNDAQINTAVSIIEAHNKQVEDLNLTLVNAKQAAAYLINQIHFGN--------------DGYFIILDEQRNII 105
jgi:Swoo_2194   40 LIKQKWVQNDAQLVTVLSIIDAHRKQVSQGKITLKDAKAEATQLINEIGFGK--------------DGYFILIDENSSII 105
WP_013660811    41 LKKERYATVKSQVMTAKQLVHITMQHSLHS--DPADIKSEVLNMLDKLRYPD--------------DGYFWILDKQGIML 104 Marinomonas m...

jgi:Bsel_2623  117 MHPA---LEGANGEELQnPDGEYVIREIKDIAKradSEDRIYYYAWEEPDG-SVEEKVLYALYFEPWEWNLSVGAYSYEF 192
jgi:Dacet_1646 108 VLGPkpeLEGKSLWDMKdANGDYLIRAMSKVAR---EGGGFHQYPWDKPSKnAVVDKLGYVVPLKGWEWFIGTGFYIDDI 184
jgi:DvMF_0616  116 VQPYnrlMEGRSGLDLRdANGVAIIVELIRTAQa-nPDGGYFSYLYTPPDSsEPEEKLSFVLPIPELACYIGTGSYLGDV 194
ACL02209       117 VQPFepsKEMTNQWDLKdSHGVYIIRELVKTAKn-kPEGGFLRYFYMPPGSdAPEEKISFVMGVKELECYIGVGRYMEDI 195
WP_003413691   114 VL-LgdsTEGTNRMNSTdVNGYKMIQEIIAKGK---NGGGYTDYYFPKEGEsEASPKRAYSKAFEPFNWVIGTGNYTDDI 189 Clostridium b...
jgi:Desru_1593 116 VH-MnpeYEGAERYNEQdQKGNFFIRGLIAAGSk--SGGGFTDFYFTKPGKqGVFPKRAYTLKFEPYDWYISTGNYIDDI 192
WP_011759767   106 AAGGqsqKIGSRVSD-------KSILNLVNEARt--KGKAVATVETLNPDTgKTDTQLAEARQFAPWQWIVITGAFVADV 176 Shewanella am...
jgi:Spea_1997  106 AHGAdasAINQNATTLFsSQDPVNLETLVSAAAh--QPVAKSQINFPNPSSgQLEPKLVEARQYAPWDWTIITGSYMSDV 183
jgi:Swoo_2194  106 SHGTspnLIGQHANKIHsQNSQLSLADMVSEAQt--ATVSKQTFFIVNPQTrAIEEKLVEARYYPAWDWTLVTGSYMSDI 183
WP_013660811   105 MHPFskgIVGSSTLDLQdIDGKLFVHDMLVTAE---SGGGFVTYSWLKPGGkTHFSKIAYVTPIDEWGWVLGSGSYIDDL 181 Marinomonas m...

jgi:Bsel_2623  193 YEAVEGAL 200
jgi:Dacet_1646 185 DDQVTIMQ 192
jgi:DvMF_0616  195 HAGERRYi 202
ACL02209       196 RKEQADFR 203
WP_003413691   190 DKEVAQKQ 197 Clostridium butyricum
jgi:Desru_1593 193 NQAVAEQE 200
WP_011759767   177 NAAMETAI 184 Shewanella amazonensis
jgi:Spea_1997  184 SDVMYSMA 191
jgi:Swoo_2194  184 NEATYEVV 191
WP_013660811   182 QSATESEV 189 Marinomonas mediterranea
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