Conserved Protein Domain Family
CYTH-like_Pase

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cl11964: CYTH-like_Pase Superfamily 
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CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases
CYTH-like superfamily enzymes hydrolyze triphosphate-containing substrates and require metal cations as cofactors. They have a unique active site located at the center of an eight-stranded antiparallel beta barrel tunnel (the triphosphate tunnel). The name CYTH originated from the gene designation for bacterial class IV adenylyl cyclases (CyaB), and from thiamine triphosphatase. Class IV adenylate cyclases catalyze the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. Thiamine triphosphatase is a soluble cytosolic enzyme which converts thiamine triphosphate to thiamine diphosphate. This domain superfamily also contains RNA triphosphatases, membrane-associated polyphosphate polymerases, tripolyphosphatases, nucleoside triphosphatases, nucleoside tetraphosphatases and other proteins with unknown functions.
Links
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Taxonomy: root
PubMed: 37 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl11964
PSSM Id: 448368
Name: CYTH-like_Pase
Created: 19-Oct-2009
Updated: 8-Mar-2022
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