Conserved Protein Domain Family
Vps16_N
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pfam04841: Vps16_N 
Vps16, N-terminal region
This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole. It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport. The role of VPS16 in this complex is not known.
Links
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Statistics
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PSSM-Id: 252829
Aligned: 5 rows
Threshold Bit Score: 471.601
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9VHG1   6 NTGEWFKVRPD-YYRKVELATPDWPLDLDLeymWVEVAPYGGPLAVTRDPtklVPVkgn-arpM--IRIFDTTGREMGH- 80  fruit fly
Q11182  20 PSSSVFLGDQQlYFTQEYLRTNSLNLKYVV---YFTACQFSGPIAVAYSP---RPA-------SwyIWIRTISGRILKRd 86  Caenorhabditis elegans
Q9H269   4 YTANWNPLGDSaFYRKYELYSMDWDLKEELrdcLVAAAPYGGPIALLRNPwrkEKAasv--rpV--LDIYSASGMPLAS- 78  human
Q03308   4 PSFDWERLKDV-FYRSRAIGELKWPTQYEEfkcALSLTV----IAVEIQDf---------------IQVYNYFGQLLGK- 62  Saccharomyces cerevis...
Q9UT38   8 PIYEWELLQDT-YYQKSAIGKAEWEYIDPVd-fMFAVAPCGGAIAITRSEsnlQSNykydqvpMysICVFCLSGQLLQT- 84  Schizosaccharomyces p...

Q9VHG1  81 ILWNh--GKlIAMGWSDMEELICIQENATVFVYDMFGREkesysIGDEA---SVTKIVEGKVFQSSAG-TGVAVMTTSGR 154 fruit fly
Q11182  87 MAFN---EP-VFMEWTRAHCLLVLNKAGRAHIFSSLGEK-----ISEVIfdsQMSDVHECRTFATSRGdSGIAVMDVDGQ 157 Caenorhabditis elegans
Q9H269  79 LLWKs--GPvVSLGWSAEEELLCVQEDGAVLVYGLHGDFrrhfsMGNEV---LQNRVLDARIFHTEFG-SGVAILTGAHR 152 human
Q03308  63 INLQrihEDiIKFEFDKDEKLILVTKSSIKIVKGW---------SPLTI---ESVPLQDPTIDTIWDYhNGIMLLAKSRD 130 Saccharomyces cerevis...
Q9UT38  85 LTWDk--TSlVGMGWNENEELIVVSKQGQVRVYNLLGEFhq-fsLGKGV---ENIGIREC-----QFSeGGVFALLQNDT 153 Schizosaccharomyces p...

Q9VHG1 155 VFLKQNSSKT--ERKLP---DIPNSSMNCSCWEIVTEGrnsycLLGRDREVIKLFPGETVGtitANLfeKP--------- 220 fruit fly
Q11182 158 VSVVNSVSEPviWSMKPpysEMPTAWTAFQPHSQLTHI-----LLIFEAVFLMGCQGESLR---EQS--HAasw---vds 224 Caenorhabditis elegans
Q9H269 153 FTLSANVG-DlkLRRMP---EVPGLQS----APSCWTV-----LCQDRVAHILLAVGPDLYl-lDHAacSAvtppglapg 218 human
Q03308 131 IYKLNGNEWEllYENKD---KKYNLLTKNHWSCNDDSIi---lLDVDHVYQVSTSNGALLKlitDSS------------- 191 Saccharomyces cerevis...
Q9UT38 154 FISITGFEEPw-rKTYA---SIPFNTLEYYNIDSWALIpn--pFSPDLGMDIVVTVGPHILqidEQDsqlh-----siss 222 Schizosaccharomyces p...

Q9VHG1 221 HERIIKISVSYNHQHLALYTNTGLLWLGSVDMRQKYCEFDTG---RKDMPLQME--WIMNsdnseaDAVVISY-PSYLLI 294 fruit fly
Q11182 225 NTKYVKCVVDDARSRIAMMTESGKIQIVSIDLSTCFCTVEIT---DHDIAKCINfgWVGN------SAVFVQMsPSLIVF 295 Caenorhabditis elegans
Q9H269 219 vssFLQMAVSFTYRHLALFTDTGYIWMGTASLKEKLCEFNCN---IRAPPKQMV--WCSRprs-keRAVVVAW-ERRLMV 291 human
Q03308 192 ---WHKVTIS-SRGFICLYNMKDNKLQIFRDPARILMEHNLD-----STPDDIC--WCGN------DTVACSF-EDEIKL 253 Saccharomyces cerevis...
Q9UT38 223 LQHVSHISISPNARYLALYESVGKVRVISSDFSKELLDLRLPetvAEASLKQMA--WCGN------DAVVLVH-ENLLTL 293 Schizosaccharomyces p...

Q9VHG1 295 VN-----RNADRSDFPYDPV-MF--LVAEMDGVRIITQSSHEIiqrLPKCVENIFAVNSQEP---ASYLFEAQKKFEE-- 361 fruit fly
Q11182 296 VNvsarrKPGDEVQIYEKMT-ANakISIEPDGIRLFESTQVEF---VEAASREKIAVLNRNPnedGAHLYKAAQEMSQgt 371 Caenorhabditis elegans
Q9H269 292 VG-----DAPESIQFVLDED-SY--LVPELDGVRIFSRSTHEFlheVPAASEEIFKIASMAP---GALLLEAQKEYEK-- 358 human
Q03308 254 YG-----PDGLYVTFWYPFTvTN--LRAEVDGLKVITTEKIYFlsrVQPQTSNIFRIGSTEP---GAMLVDSFSLLED-- 321 Saccharomyces cerevis...
Q9UT38 294 VG-----PFGGSVPYLYNHT-PI--VSTEVDGVRILTKDSSEFlrkVPAPLENIFHIGSKTP---GAKLVEAFQKMKL-- 360 Schizosaccharomyces p...

Q9VHG1 362 -KSYKSDEylSMCREk--IDLAVSECIEAASYEFCPETQKSLLRTAYFGKGFiRNHNPD--EYMR 421 fruit fly
Q11182 372 gHNSFAAS--TVIQD---LYKAIDDCISTACDTWQPEEQKLLLKAARFGMAY-TNTTPDttKLMR 430 Caenorhabditis elegans
Q9H269 359 -ESQKADEylREIQElgqLTQAVQQCIEAAGHEHQPDMQKSLLRAASFGKCFlDRFPPD--SFVH 420 human
Q03308 322 -HAPKAIEilKNFv----LEKGVLDCIAAAIDEFEPKLQKMLLNAASYGKASlQYKSFD--ASIF 379 Saccharomyces cerevisiae S288C
Q9UT38 361 -KSVFAEKmlLELKDe--LHDAVDTCVQASLNEFSIEWQKVLLEAASLGKNSlRMYNHQ--EYVD 420 Schizosaccharomyces pombe 972h-
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