Conserved Protein Domain Family
T7SS_EccC_b

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TIGR03925: T7SS_EccC_b 
type VII secretion protein EccCb
This model represents the C-terminal domain or EccCb subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking]
Statistics
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PSSM-Id: 274859
Aligned: 22 rows
Threshold Bit Score: 621.242
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KCG25422      308 KIVDVLRESLYNVPhRSPRRPWLAPLEDPEPV--DRLVAAYRGKPWH----VDYGQNPGLMFPVGVMDIPEESQQVVHAV 381  Mycobacterium...
WP_010986844  751 TEMGVLVEQIENADtAPVRQIWLPPLPDAIAL--DKVAGPLDVGARGmq---laKRRGPLQVPLGVLDDPTKQWQGQWYL 825  Streptomyces ...
WP_005524361  725 ALVAAAQVVARSWH-QSAHTMWLPPLPAAIPL--TDIITQS-------------VTPNTLCATIGRIDRPFLQQQDPYVL 788  Corynebacteri...
WP_005328026  707 EVVRAAAEEAQLRD-QSAHRIWLPPLPPVIEL---SALPGLSGVQAVgavsPA-ADQRQLCAPIGIIDRPYYQRQDELII 781  Corynebacteri...
WP_003892037  750 KLIATIGDQLAAYG-PKAPQLWLPPLDEPIAL--ADVLAGADVEP------------GQLRWPLGEIDKPFEMRRDVLVY 814  Mycobacterium...
WP_005524944  764 TTLDLVVSRLTTAA-EKTRQIWLPPLPEHLSF--DGVLTNIDVHPDTgl---gaDREGYLHVPMGIKDKPLTQWQGPMVL 837  Corynebacteri...
WP_011726639    9 VLREVVLSQLATGE-SRAYKMWLPPLTDPTPV--NELVERD-------------YQRRPLRFGLGIMDEPRRHRQEVWGV 72   Mycobacterium...
WP_016422088  716 TVLGAVVAAVSHVP-TRAHRVWLPPLPEAIELqpDEQLPR-----------------QRLTGVIGLVDKPLFQRQDPLRI 777  Corynebacteri...
BAB97970      673 AVVARAISAAKLRG-LSAHRIWLPPLPAEVSI--GALA----------------DDVGELSAVIGMIDRPYQQRQDPLLI 733  Corynebacteri...
EUA75086       64 SVIDTILDRVEGHG-NPAHEVWLPPLDDSPTL--GDLIPRHGRAG--------FDAVGSLTVPIGIVDRPYEQRRDPYIV 132  Mycobacterium...
KCG25422      382 DAL----RSNIIVVGAKQRGKTTTLMALMCSAATMYTPERVTFFCI--GGATMAQIGSLPHVTDIVSPKDAEGIERILST 455  Mycobacterium...
WP_010986844  826 DLTv--aGGHAAVIGGPQSGKTTLLRTLALSLSLTHTPQEVGIYGLdlVGGGLQALSGLPHVGGVAGRADRERAGRTIDS 903  Streptomyces ...
WP_005524361  789 EFSg--qQGHAMICGGPQTGKTTALRTIVLALACTHTTDYLRFYILdlSGNDLESLSLLPHVAGVAHQHDTEKIARIIDE 866  Corynebacteri...
WP_005328026  782 DFTq--hGGHMALCGGPQSGKSSALRTIVSALALRHDPQTARFYVIdlGGGQLTSLERLPHVAGVAGREEGEKVRRIVDE 859  Corynebacteri...
WP_003892037  815 DAHt--aAANVLIHGGPRSGKSTALQAFVLSAAALHSPRAITFYCLdyGGGKLADLADLAHVGSVATPLEPERIRRTFGE 892  Mycobacterium...
WP_005524944  838 DLAg--aGGNVAILGAPQTGKTTALRSLILGAALTHTPHEVNFYIVdmSGSAFGYLAQLPHVGDVVTRFDEDKLRRTIAE 915  Corynebacteri...
WP_011726639   73 DVSa--aGGNIAVGGAPQTGKSTFLQTLVVSAAATHTPRQVQFYCVdlGGGGLMYLEDLPHVGGVATRAEPDRVNRVVAE 150  Mycobacterium...
WP_016422088  778 DLRt--tGGHVAIVGAPRSGKTTAARTAVLALADGISARDLHFYIVdcGAGGLSDLAELPHVASVAHRGDEELIRRTLGF 855  Corynebacteri...
BAB97970      734 DFSlnggSGHWAICGGPQTGKSTALRSIVISMAATHSTENIRFYVLdlSGTSLENLSRLPHVAGVAGRKDPEKVRRVVDE 813  Corynebacteri...
EUA75086      133 DLSa--aAGNVAIVGAPQSGKSMAVRTLVTSLAVTHSPAQVQFYCLdfGGGTLTSLAQLPHVGSVASRLESDLIRRTFAE 210  Mycobacterium...
KCG25422      456 MDALIDAREEAFRRAKID-MDGFRERRFgIGGdgvggtdP--TDAFGDVFVVLDDY---DDLYAKDTL-------LGDRI 522  Mycobacterium...
WP_010986844  904 VRGMLNQREELFRVHNIDsLEQLRDLRAaGRL-------P--ELASTEIVLLIDGF---GALRDDFEE-------LDDAV 964  Streptomyces ...
WP_005524361  867 VCGFIDQPEPR------------------------------------HTFLIVDGW---HVLHGDHED-------LMEKL 900  Corynebacteri...
WP_005328026  860 VAGFIRRPERC------------------------------------ATFLVIDGWhhiGTSNAEFED-------IAEKV 896  Corynebacteri...
WP_003892037  893 LEQLLRARQ---RQGAVNrTGSY-------------------TDGYGEVFLVIDNL---YAFSRDNTDtfntrnpLLAKV 947  Mycobacterium...
WP_005524944  916 MEAFLHERETLFERHQISsVQQMRDMHVqGRL-------P--ELFAADVFLVVDGW---GTMRKDYDD-------LAETV 976  Corynebacteri...
WP_011726639  151 VKAVLRAREQVFKQYRVGsIASYREMRDdPNN-------PasQDPFGDVFLVIDGW---PAFVAEFPD-------LEPAV 213  Mycobacterium...
WP_016422088  856 LRREVSRREQLFRTNGWLsSEAARAA----------------GQP--DSVLVIDGW---GAFKTEFPA-------LSDDV 907  Corynebacteri...
BAB97970      814 VRGLINHPEQR------------------------------------HTFLIVDGW---HTITQEFDE-------LFDAF 847  Corynebacteri...
EUA75086      211 MLTIVRSRENAFRAYGIDsMAEYRRRKGaGDP-------QlaNDPFGDVFFIIDGW---STVRQEFEA-------LEPQV 273  Mycobacterium...
KCG25422      523 ISLSSRGPeYGVHLMCSAGGWiHGQRQSLLQNVTARIQLRLADPGESQMGHlsiesREAARRTLnRPGFGLTESLHELRI 602  Mycobacterium...
WP_010986844  965 VDILKRGGgYGIHVVAGMLRW-NDVRIATQSQFGTRVELRLNDPSESSIDR-----KLAETLAPeEKGRILTDGKLFAQV 1038 Streptomyces ...
WP_005524361  901 GRIVADGLaARVHLVLTATRW-SVVRPAIRDLIPQRIETKLGEPMDSLIDR-----KAQLKVPA-LPGRGLTSSGETMLI 973  Corynebacteri...
WP_005328026  897 TEIVADGAsAHVHVVIATSRW-TTMRPAIRDLIANRLELRLGEALDSLIDR-----KLQQKLPS-APGRGLTLAGENMLL 969  Corynebacteri...
WP_003892037  948 TELANSGLaYGIHVVITTPNW-LEVPLAMRDGLGLRLELKLHDSHDSIVRVagalrRPADSVPAdQPGRGLTMAAEHFLF 1026 Mycobacterium...
WP_005524944  977 EKLAQRGLgYGIHIIFGTGRW-PDFRLPVQAVIGTKVEFRLNDSLDSCVAK-----RVNEKLANeTTGRCITSDELISQV 1050 Corynebacteri...
WP_011726639  214 QDIAGQGLaYGVHVIITTPRW-TELKSRVRDYLGTKIEFRLGDVNETQIDR------ITREIPAnRPGRAVSLEKHHLMM 286  Mycobacterium...
WP_016422088  908 QALVADGLaVGIHVLLTAHRW-TDMRPAVRDLIGTRIELRQAESMDSMIDR-----KAAELVPE-SPGRGVAPGGFAMLV 980  Corynebacteri...
BAB97970      848 VDIAANGLaSRVHLVLSTQRW-SSIRPAVRDLVTGRIELKLGEAMDSVIDR-----KAQLRIPS-KPGRGLNLDKEHILI 920  Corynebacteri...
EUA75086      274 TALAAQGLgFGVHTVVTASRW-AEIRPALKDQIGTRVELRLGDPLDSDFDR-----KLAQLVPDgRPGRGITRDRRHMLI 347  Mycobacterium...
KCG25422      603 GVPALADPGTGELv--gITDVGARIADVAGVTKHASLQRLPQRVELSAIVEheavH------QGGDDLSIAFAIGERhEL 674  Mycobacterium...
WP_010986844 1039 ALPRTDGLPDKADlgavLERTARTVRATWTGEVAQPVRVLPHILEPQLLPG-----------PAAEPRRVPIGLDQT-QL 1106 Streptomyces ...
WP_005524361  974 ALSAQQDVA------------FIARSLVADQPPVPQLKLLPISLMLADLPQ-----------LDPEQNSVLLGVGGP-KL 1029 Corynebacteri...
WP_005328026  970 ARTSNQDIA-------------HICRVHAAADPVPQLKMLPAVLTPSALAA----Q------GGVPTGEIAWGIGGR-DL 1025 Corynebacteri...
WP_003892037 1027 AEPALSDIA--------------VINARYPGVSAPPVRLLPTDLSPDALAP-----------LYPAPETVVIGQREE-DL 1080 Mycobacterium...
WP_005524944 1051 ALPIMDNPSLVHEa--tPEALVSAINQAWEGRSAPAVRMLPELITYRDLIH-----------QHQGHEPALVGIAES-NL 1116 Corynebacteri...
WP_011726639  287 GVPRLDGVHSADNiveaISSAVQQIADRHT-DQAPQVRVLPERIYLHQLDP----NppgpdsDYRTRWQVPLGVRES-DL 360  Mycobacterium...
WP_016422088  981 ALTGAADTK-------------RIVETVPHGEQAPKLQLLPRRIDIARLPR----P------AAATRGAIAVGLEEA-GL 1036 Corynebacteri...
BAB97970      921 AHASGQDIAQ-----------VCVMADGQGWQQVPQLSVLPAHILLHEL-------------ELSATPGIPIARGGA-EL 975  Corynebacteri...
EUA75086      348 GLPRVDSISSNQDlgeaIAAAAASMRQRSSVE-APQVRMLPHKIDYAALVP----Qap---qNDQPNLRILVGINES-EL 418  Mycobacterium...
KCG25422      675 GPVPIK-LRESPGLMILGRQGCGKTTALVAIGEAVMNRFSPQQAQLTLIDPKTAPHGL--RDlhaPG--YVRAYAY---D 746  Mycobacterium...
WP_010986844 1107 APVLLDlFAHDQHLVIMGDSECGKTNLLKVIADGLIERYSEDELVFAVMDPRRGLRGA--IP---EE--YRGGYAY---N 1176 Streptomyces ...
WP_005524361 1030 GAVNWD-YLASQHIVCIGAQESGKSTLISTIIAGLTQ-IGRERARLIVIDHRRSHLGA--ID---PD--MLAGYSA---S 1097 Corynebacteri...
WP_005328026 1026 DTLTWN-PSREPHLVAIGAQGCGKSTFLAQIMRGISA-FAREDARLVVIDQRRAHLGT--LD---QN--MVAAYAA---T 1093 Corynebacteri...
WP_003892037 1081 APVAVD-FANHPLLMVFGDSKSGKTTLLRHIIRTVRENSTPDQVAFTVIDRRLHLVDEplFP---DN-----EYTA---N 1148 Mycobacterium...
WP_005524944 1117 SPVHFNlNRDQRHLIVIGDSQTGKTSFLKNIIAEVCRGKKSRFAVFGIVDLRRSLLGF--LT---DDdpQFGGYAG---M 1188 Corynebacteri...
WP_011726639  361 TVAYNQ-MHLTPHLLIFGAPKSGKTRIAHAVAQAICKRNSPQQVRFMLADYRSGLLDA--VP---QS--HLLDAGAinrN 432  Mycobacterium...
WP_016422088 1037 GAVIFH-PEKDRHLLIFGSAGSGRTAALRGIVHQL--RYSQLDSKFVVIDYRRGLMEA--VP---QE--RLAGYAG---S 1103 Corynebacteri...
BAB97970      976 STLTWD-PESSRHLLAFGSQGCGKSSLIRTIVTGLTI-VGREKARLVFFDLRRTHLGL--VP---ED--MLAAYCA---T 1043 Corynebacteri...
EUA75086      419 APTFLE-FGEQPHMMIFGDSECGKTALLRTMCREIVRTTTPQQAQLFIVDYRRTLLGV--VE---TE--HLAKYAM---S 487  Mycobacterium...
KCG25422      747 QDEIDEVITELAqQILLPRLPPKGLSQEELRALKP-WEGPRHFVLIDDVQDLRp--AQSYPQ------KPPVGaalwkLM 817  Mycobacterium...
WP_010986844 1177 SKLCAGLSAGIA-TELEKRLPDESADSEDLEPGSW-GSGPRIVILVDDYDVLTt--AGQQPL------APFIP-----YI 1241 Streptomyces ...
WP_005524361 1098 TQETEKLVAAMK-ITLEERLPSAEVTPQQLKDRSW-WTGPDIFLIVDNLDLVA-----DMAF------APLLS-----VL 1159 Corynebacteri...
WP_005328026 1094 QSSAQETIVDTV-RTLESRLPGPDITPAQLTARDW-WQGPDIYLVIDDADLLS-----DIAL------SPLLE-----LL 1155 Corynebacteri...
WP_003892037 1149 IDRVLPAMLGLS-ALIEKRRPPAGLSAQELSR--WtYTGHTHYLIVDDVDQIPdtpAVSGPFvgqrpwTNIVG-----LL 1220 Mycobacterium...
WP_005524944 1189 RAGVTPLVEGIK-GILDSRLPPDNVTVEQLKNRSW-WSGPETYLVIDDFDMIE---GSGNPL------KPLVP-----YL 1252 Corynebacteri...
WP_011726639  433 SATLEEAIKALA-VNLKKRLPPPDLTTAQLRARSW-WSGPDVVLLVDDWHMVTaaaGMVSPM------APLGP-----LL 499  Mycobacterium...
WP_016422088 1104 AAVATPMLAELA-EVLKARLPQPDITPAQLKARNW-WSGPTINVIVDDYDLVAg--SRGNPL------QPLAE-----VI 1168 Corynebacteri...
BAB97970     1044 STAVHNTIKDMV-ATLSARLPGPDITAQELRDRSW-WQGPDIYLVIDDYDLLP-----AGTL------HPLRE-----II 1105 Corynebacteri...
EUA75086      488 SNTLVDEVPALI-ELLKSRMPGPDVTQQELRDRSW-WSGPEIYILVDDYDLVAl--ASGNPL------LPLAE-----YL 552  Mycobacterium...
KCG25422      818 ERARQVGLHVFSTRNSANWATMPMD-PWVKSQTSAKVAQLYMDNDPQN-RINRSVRAQTLPPGRGLLVGADGDVEGILVG 895  Mycobacterium...
WP_010986844 1242 PSAVDIGLHFVLTRRVAGAARGLYE-PLLQGLRESGASALVMAGDRSEgQLFPGVYATQQPSGRGVLVRRGEPNRLIQTV 1320 Streptomyces ...
WP_005524361 1160 PHARDVGLHVVITRKSGGCVRALFQ-PFLAEIKDQSPFIIVLDADKDDgPLFG-VRLKPQPPGRGVMIHHGTQQGLIQIA 1237 Corynebacteri...
WP_005328026 1156 PHARDIGLHLVIARKSGGIGRALFG-QFFSAVRDLQPALLLFDADRDEgTIFG-LKPCHQPPGRGQWSIRGENLGVAQAV 1233 Corynebacteri...
WP_003892037 1221 AEAADLGLRVIVTARATGSAHAVMTaPLLRRLNDLQATTLMLSGNPTDsGKIRGHRFARFPAGRGLLLTDTDTPDHIQLV 1300 Mycobacterium...
WP_005524944 1253 PQSEDLGLHIIVARRSAGVSRSSYD-PVMQGLREAGANGILLSGDRQEgSVWPKVFLKKLPPGRAQWVTRSGKPQMVQLA 1331 Corynebacteri...
WP_011726639  500 PAAADIGLHVIVTCQMSMAHRATMD-KFVGAAYGAGSPTLFLSGEKNDfPSRD-IIVKKRPPGQAFLVGPD-GKEVIQAA 576  Mycobacterium...
WP_016422088 1169 AHAADIGLNIFFARRISGALRSLHD-PVMGAVKDQGASVFVMDGTRDDgPILG-VKPCEQPPGRGYWVAHGQSPQVVQLG 1246 Corynebacteri...
BAB97970     1106 PHARDVGLHIVLTRKAGGASRALYD-PVMSEIKDQSPHVVLFDADRDEgAILG-IKPTAQPPGRATMSIRGENIGVAQMA 1183 Corynebacteri...
EUA75086      553 PHSKDIGLHVVIARRTSGASRAMFE-PMMARMKDLSCIGLQMSGNKDEgVLLGTVRPSEQPPGRGTLVMRSGGQQLIQVA 631  Mycobacterium...
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