Conserved Protein Domain Family
Sec16_N

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pfam12935: Sec16_N 
Vesicle coat trafficking protein Sec16 N-terminus
Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region.
Statistics
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PSSM-Id: 315590
Aligned: 15 rows
Threshold Bit Score: 142.594
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P48415        291 EPSENKIRNSgDDTSM-LFQDDESDQKVPWEEdvkkdfhNEn-TNNTQESAPNTDDRDKgyegnealkksescTAADERS 368  Saccharomyces...
Q5AYL5        275 DLWGSPKSVD-NGEDR-FFDQLRTQTKPIYFP-------SE--ESRFEEGVPLLDGSAEapvea----apveaTPVEQAV 339  Aspergillus n...
A1CME3        227 GFWGNLGNDGrDNEDD-FFDQLKTQTKPIYVP-------PEt-ESRFEEGVPLLDNSPQ--------------TPVEQAQ 283  Aspergillus c...
Q4WD95        196 GFWDSLGDNErDNEDD-FFNQLKTQTKPIYSP-------PEt-EARFEEGIPLLGQGAA--------------PQNNHAH 252  Aspergillus f...
EKV12203      377 PFWTNEASGKvDSDEDdFFNQLNSQTKPIFAPpeaepgsPEa-EPMFEEGAPLLDKPTT--------------ASPQRRL 441 
CAP86631      354 PFWKNEPSGEgDSDDG-FFNQLNSQTKPIFAP-------PEa-ESRFEEGVPLLDESTP--------------ASPQQPL 410 
EEA26879      186 NFWEAEATDD---EEE-FFDQLKTQTKPIYVP-------PEa-ESRYEEGVPLVENEVD--------------IQPEGVN 239 
XP_002847614  236 LPWNDAAQDGeVEGED-FFNQVSTQTKPIYIP-------PEfaESRFEEGLPLVDNGDQn------------yGEPVTES 295 
XP_003239246  232 PLWNDDVDNEaEGED--FFNQVSTQTKPIYIP-------PEfaESRFEEGLPLVDNGDQs------------nDQQAAQP 290 
Q1DHP3        196 NSWNSVFADDeGGGD--FFSQISSQSKPTVAH-------LEs-EPRSDDMASHLSNGN---------------VQPSNES 250  Coccidioides ...
P48415        369 YSEETSEDIFHGHdkqvVEGQNDFTGKNIENESQKl-------------MGEGNHKLPLSAEADIIEPGKD-IQDQAEDL 434  Saccharomyces...
Q5AYL5        340 PQPGQLDRVFEGD----EDEDDGFFSSAQQPATEN--------------EPQEPVHIQRKSTSQVLDSLNT-NRDGVHSP 400  Aspergillus n...
A1CME3        284 RGDNQLDNVFAGD----EDDEGDFFNEIQKSTP----------------EEGPF-HITRKSTTQVLSTLDT-TPDSPFSE 341  Aspergillus c...
Q4WD95        253 KGESQVDDVFGDD----EDDESGFFSEIQKRTSA---------------EGPP--PITRKSTSQVIDSINA-VSDSMFSK 310  Aspergillus f...
EKV12203      442 EEDKSIDSVFTND----EDDADRFFSSAPKLEDKNgdenflgstskedaEEQPVDHFARNSTSQVLESAGF-VLDSPVSD 516 
CAP86631      411 EQGKSIDNVFSND----DDDADGFFSSASKPEAKNddedffgsiskeeaEEQPVVHLERKSTSQVLESAGF-ALDSPVSD 485 
EEA26879      240 KGEPQLDDVFGDD------DADDFFASTATKDGTT--------------SEKP--TVLRKSTYDVLGSLDNgIPDSPVGD 297 
XP_002847614  296 RPQNTLDSVFGEDm---ATEEAGFFSSNLATAEKLs-------------DEPP--SLHRKQTSQVLDSLK--LDDAFLGD 355 
XP_003239246  291 KQQSALDSVFSEDi---TTDEAGFFSSDMSHAAEPs-------------EAPP--TLHRKQTSQVLDSLR--MDDAFRGD 350 
Q1DHP3        251 QQTKAIDSLFQEDe---STGEADFFNSQGPA------------------HVEPSLELLSETQPNSM------PEDHPLPS 303  Coccidioides ...
P48415        435 FTQSSG-DLGEVLPwestdknADVTSKSQEKhedlfAASGNDEKLPWEVSDGEvsSGKTENSMqtSTEkIAEQKFSFLEN 513  Saccharomyces...
Q5AYL5        401 LSPTAE-EFNDIIA-------AAASKSPENVq---ePASEEDLAARWQAELSD--DDLEVAPV--EED-LAAKWQAELDD 464  Aspergillus n...
A1CME3        342 TSPTAQ-DFNQILA-------DTSAQNETKE------PSDADLAARWQAELSD--DAEETMPP--EDD-LAARWQAELDD 402  Aspergillus c...
Q4WD95        311 QLPAAA-ELNNSLA-------VPTADGEIKN-----SPSEEDLAARWQAELSD--DADETMPT--EDD-LAARWQAELDD 372  Aspergillus f...
EKV12203      517 SSAAAQ--FDDALK-------VALLEPQTTV-----DPSEEELAARWEAELAD-------SP---DDD-LAARWEAALDD 571 
CAP86631      486 ASAAAQ--FDDALK-------AASLEPQTTA-----DPSEEELAARWEAELGD-------SP---DDD-LAARWQAALDD 540 
EEA26879      298 -SPAAF-ETKE----------------------------DDDLAARWQAELDDveDIPDTKEPkeEED-LAARWQAELDD 346 
XP_002847614  356 DSPIEP-HLTSGQQ-------FPSSGEPDEA-----TTSKDDTVP---TENLD------------ENE-LAERWKAALDD 406 
XP_003239246  351 ESPIEP-PGAPCEQ-------LSTSEAVGGH-----QTSKDDATT---MENLD------------ENE-LAERWKAALDD 401 
Q1DHP3        304 LDPGKElPHHQSVA-------VVQDEKPEVI-----RPAEPGVAENLG-----------------EEE-LAERWKAFLGD 353  Coccidioides ...
P48415        514 d--DDLLDDDDSFLASS------EEEDTVPNTDNTTNLTSKPVEEKKaSRYKPIIEE-----EAGMR 567  Saccharomyces cerevisiae S...
Q5AYL5        465 ---DDLLLEDEPSDLAQnt---aAEVVNGHGVEPNLQALGSPFGTPQ-NPSKPKPAQ-----SVYTP 519  Aspergillus nidulans FGSC A4
A1CME3        403 d--DDDLLLDEASTANNdq---eAAQLNQDHNAGFAASLQSPFGTPE-NPARPKAQP-----ISYTP 458  Aspergillus clavatus NRRL 1
Q4WD95        373 d-dDDLLLDDDTTNAQR------PPEAANIDHMNDTSMLQSPFGTPE-NLARPKVQP-----VSYTP 426  Aspergillus fumigatus Af293
EKV12203      572 ---DDILLEAEAAQSVSaqe-qiNQTPIQSTHNGLSAGLNSPFQTPQ-AFPQPRPVP-----NIYTP 628 
CAP86631      541 ---DDILLETEAAQSVPaqg-hiHQTPVQSTNNGLSAGLNSPFQTPQ-AFSQPIPVP-----NVYTP 597 
EEA26879      347 ---DDLLLEDNALNGT-------QEEPTFFTGDSAGDTRSAQLPTPS-NYT-----------NPYAP 391 
XP_002847614  407 dllDDGLLDDDLLD---------NDNASQPIQNEKPPAPSQHYPPSQ-SAYLPQAPPalasiNPYAP 463 
XP_003239246  402 dllDDELLDDDLLDNDNaaqqedEKPPAPPPSQRYAPNTSTCL--PQ-SRPAP-PPI-----NPYAP 459 
Q1DHP3        354 ---DDILIENET-----------LDGSIEGANTHTAEYQRHPVQPAS-QVGSEQPPV-----NTYTP 400  Coccidioides immitis RS
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