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Prion-like protein Doppel Dpl is a homolog related to the prion protein (PrP). Dpl is toxic to neurons and is expressed in the brains of mice that do not express PrP. In DHPC and SDS micelles, Dpl shoes about 40% alpha-helical structure however in aqueous solution it consists of a random coil. The alpha helical segment can adopt a transmembrane localization also in a membrane. The unprocessed Dpl protein is thought to posses a possible channel formation mechanism which may be related to toxicity through direct interaction with cell membranes and damage to the cell membrane. It is suggested that the peptide is neither in an entirely random coil nor in a completely alpha-helical conformation, possible continuously interchanging between the two conformations.
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PubMed References
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Jiyao W et al.(2023). "The conserved domain database in 2023.",