Conserved Protein Domain Family
MCM2_N

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pfam12619: MCM2_N 
Mini-chromosome maintenance protein 2
This domain family is found in eukaryotes, and is typically between 138 and 153 amino acids in length. The family is found in association with pfam00493. Mini-chromosome maintenance (MCM) proteins are essential for DNA replication. These proteins use ATPase activity to perform this function.
Statistics
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PSSM-Id: 403724
Aligned: 21 rows
Threshold Bit Score: 75.5248
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001525450         92 NDLEDEIQN-DVADLN---PS----DEEEGDDLM-DN-FERDYRENAEQDHYD-LgdHNIDDTgDFDEMDMATRRRIDEQ 160 
XP_009158281         52 LGPEDDLIG-DIDDAD---ELa---EEEDGIDLFgDT-FMDDEREGRDQETYQ-G--RMIDDEgDYDDLDLAERRQLEAR 120 
GAD94620             57 RDEEAEMLD-DIDDID---EMa---EDEDGIDLFgDN-FDRDERSGRHDEDYG-G--VGIDDEgDYDELDPAARRQLEAR 125 
WGS:AATM:SJAG_02348  44 EAEEAVVEE-EIGELDdelPDp---NEEDGEDLFgED-MEKDYVQNLELDRYD-I--DDLDDEnEFETMDIGERRALEQK 115 
P40377               43 EAAEALVEE-DIEDLDgeaLDv---EDEEGEDLFgEG-MERDYQQNLELDRYD-I--EELDDDnDLEELDIGARRAVDAR 114  Schizos...
EPY49349             43 EAAEALVED-EIEDVDnenVDv---DDEDGEDLFgED-MERDYQQNLELDRYD-L--DELDDDnELEELDLGDRRIIDEK 114 
XP_001732725         65 MDSHSMLDQvDDDPDDlvnGAe---NEDDGEDLFdDT-MMADYRANPELDTYEaV----GLDEaDFEHMDATTRQLAELR 136 
XP_001830245         49 pppfsdtdEsGIDDRDgllDAegedEEEDGEDLF-EN-LEADYAPNELLDRYS-D--ADIDDDgDAAELSAAQRRAAEAQ 123 
Q5KDY4               64 ADDEAEVRRiGRENGDd-------dEEEEGEDLFnDD-MMADYEENAGLDTYS-Q--ADLDDRsSVAGPTRAERLAAERA 132  Cryptoc...
EKC97426             57 DDEEAEMRArGRRDAG---DEd---TDDEGEDLFnDDnLQRDYEVNPELDRYS-D--AGLDDRsSVQEMSRADRLAAERE 127 
XP_001525450        161 LNRRDAILK-------NASRSR-GGVFLDDDE-DDdedaegirgqnEGMDQYGLPIQRRRRRQHfdddNAD----QDDML 227 
XP_009158281        121 LNKRDREL---------ARRRRmPAAFMPDDD-DD-------------AGID-LTRQPRRRRHHy---DEDq---EDMDL 170 
GAD94620            126 LNKRDREL---------ARRRRmPAAFLQDDD-DD-------------MNVDNLTRQPRRRRHHy---DEDa---EDMDM 176 
WGS:AATM:SJAG_02348 116 LNERDQKSGk------aSGKGK-PAAFLQEDD-E------------DLNSDFGFPF-KHRNRQY------DelepTATVM 168 
P40377              115 LRRRDIELDa------aAGRTK-PAAFLQDED-D------------DLDSNLGTGFTRHRHRIY------DeyspNVGAL 168  Schizos...
EPY49349            115 IQRRDMELEa------aAGRTK-PAAFLQDED-D------------DLDSNIGLGIPRHRHRVY------DefapNAGAL 168 
XP_001732725        137 MARRDRAEGvgrm-------srrAPVFLQSDDeSEd-----------------DVLRQRRRRRHy-----------DEVQ 181 
XP_001830245        124 MARRDRLERagkkgsrAFIRTK-APTFLGSDDmDDd---------gDVDDELGLSQFKARTRRHy-----------DERR 182 
Q5KDY4              133 MDLRDRGVSgr----rAGRRDH-MPAFLQSDD-DEa---------eAFGDDPLAGINIRRRRRQy-----------DERM 186  Cryptoc...
EKC97426            128 MARRDRGLTgg----rAARRGR-VPTFLQSDD-DDd---------gAVDGGLLSGINTRRTRRQy-----------DERM 181 
XP_001525450        228 DDMeIDPFNEELSLESLTDIKAPSI 252 
XP_009158281        171 DE---NIMEEELSLETLQDVKASNI 192 
GAD94620            177 GD---DIMEEELSLEELADVKASNI 198 
WGS:AATM:SJAG_02348 169 DE------DGELQLEAIADVKADSI 187 
P40377              169 DE------SGELPLESIADVKADSI 187  Schizosaccharomyces pombe 972h-
EPY49349            169 DE------AGELPLESIADVKADSI 187 
XP_001732725        182 EED--AAEVDELPIEQLSDIKADSI 204 
XP_001830245        183 DQDdMEGIEDELPLEQLGDIKAKSI 207 
Q5KDY4              187 DEDdVEEDEEEMSLEHLGDVKAASI 211  Cryptococcus neoformans
EKC97426            182 DEDdIEED--EMSLEHLGDVKASSI 204 
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