Conserved Protein Domain Family
Prion
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pfam00377: Prion 
Prion/Doppel alpha-helical domain
The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.
Links
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Statistics
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PSSM-Id: 425648
Aligned: 12 rows
Threshold Bit Score: 147.915
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005058014 134 MSGMHYRFDSPdEYRWWNENAARYPNQVYYRDYrdQRGPVPQDVFVADCFNITVTEHNIGPAAkrnaseagaavNQTEAE 213
Q9QUG3        64 GRKLDIDFGAE-GNRYYAANYWQFPDGIYYEGC--SEANVTKEMLVTSCVNATQAANQAEFSR-----------EKQDSK 129 house mouse
EHB04955      25 gHKLDIDFGAK-DNQYYEANYWQFPEGIHCDSC--SEANVTKEMLVTVCINTTQAANQAEFSR-----------EKQDNK 90 
XP_013015027  61 gHKLNIDFGAE-GNRYYETNYWQFPDGIHYNGC--SDTNVTKEVLVTSCINATQAANQAEFSR-----------EKQDNK 126
XP_005320559  43 GRKLHIDFGAE-GNKYYEANYWQFPDGIYYDGC--SEANVTKEVFIAKCINATQAANQAEFSR-----------EKQDNK 108
XP_525256     63 GRKLDIDFGAE-GNRYYEANYWQFPDGIHYNGC--SEANVTKEVFVTGCINATQAANQGEF-------------QKPDNK 126
Q95211       133 MSRPLIHFGNDyEDRYYRENMYRYPNQVYYRPV--DQ-YSNQNSFVHDCVNITVKQHTVTTTTk----------GENFTE 199 rabbit
XP_003226790 142 MSNMQFGFPNQyDERWWYQNRDRYSDQVYHPPY--NP-SVSREVFVRDCVNVTVTEY-IQPTG-----------NQTADE 206
P27177       147 MSGMNYHFDSPdEYRWWSENSARYPNRVYYRDY--SS-PVPQDVFVADCFNITVTEYSIGPAAkkntseavaaaNQTEVE 223 chicken
XP_016286902  64 GRKLVIDFGEE-GNSYYATHYSLFPDEIHYAGC--AESNVTKEVFISNCVNATRVINKLEPLE-----------EQNISD 129
Q9GJY2        63 GRKLDINFGVE-GNRYYEANYWQFPDGIHYNGC--SEANVTKEKFVTSCINATQVANQEELSR-----------EKQDNK 128 sheep
XP_012395394  83 GRKLSINFGEE-GNSYYEAHYKLFPDEIHYVGC--AESSVTKDVFISNCVNVTHTANKLEPPE-----------ERNSSA 148 Tasmanian devil

XP_005058014 214 LEARVVTKVIREMCIQQYQE-----YRLGSGMR-PHLADASLAALLLLVLFAL 260
Q9QUG3       130 LHQRVLWRLIKEICSAKHCDf---wLERGAALR-VAVDQPAMVCLLGFVWFIV 178 house mouse
EHB04955      91 LYQQVLWQLIKELCFGKRCDf---wLERGAGFQ-VAMDLLVVLCLLLFMWVLV 139
XP_013015027 127 LHQRILWRLIKELCSAKHCDf---wVNSGAGLQ-VAVNQPAMLCGLLIIWGLV 175
XP_005320559 109 LHQRVLWRLIKELCSVKHCDf---wLEGGAGFQ-LSVDQPVMLCLLVFIWLMV 157
XP_525256    127 LHQQVLWRLVRELCSLKHCEf---wLERGAGLR-VTMHQPVLLCLLAFIWLMV 175
Q95211       200 TDIKIMERVVEQMCITQYQQesqaaYQRAAGVL--LFSSPPVILLISFLIFLI 250 rabbit
XP_003226790 207 VEMRVVPLVVREMCTEQ--------YRLLSGVAlSLLANPSLVFTITLALCFL 251
P27177       224 MENKVVTKVIREMCVQQYRE-----YRLASGIQ-LHPADTWLAVLLLLLTTLF 270 chicken
XP_016286902 130 IYSRILEQLIKELCALNYCEf---rTGKGTGLR-LSLDQYVMVYLVILTCLIV 178
Q9GJY2       129 LYQRVLWQLIRELCSIKHCDf---wLERGAGLQ-VTLDQPMMLCLLVFIWFIV 177 sheep
XP_012395394 149 IYSRVLEQLIKELCALKYCEf---gMQIGAGFR-LSLDQSMMVYLMILAFFIV 197 Tasmanian devil
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