4C0D,5AJD


Conserved Protein Domain Family
Not1

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pfam04054: Not1 
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CCR4-Not complex component, Not1
The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.
Statistics
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PSSM-Id: 427680
Aligned: 103 rows
Threshold Bit Score: 325.237
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4C0D_A        439 LLELNAPEh--VLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAhTPQQKGWPMYAQLLIDLFKYL 516 
CCE64445     1530 FVNINDAKirnEFIKFDSEFYEIFSTYLLALQPLAYPGFSFAFITLLSHRMFLPVMLR-LPENKGWENLTLLIIALFKFL 1608
XP_001643066 1359 FIKITDQQirkELIEFDNYFYNTFASYLHLIQPVAFPGFSFAFITLLSHRMFLPNMLR-LENKSGWKNLTILIIDLFRFL 1437
CCC70050     1701 FIKVADQKtrkELLSFDAEFYNIFASYLHSFQPFAFPGFSFAWISLLSHRMFLPVMLR-LPQKAGWEKLMLLLIDLLKFL 1779
CCD26596     1728 FIKVSDSQtrkELANYDVDFYNTFASYLHSLQPFAFPGFSFAWISLISHRMFLPIVLR-LPQHGGWEKLMLLIIDLFKFL 1806
CCK72050     1695 FASITNKEtrkELRNFDVEFYNIFASYLHSLQPFAFPAFCFAWVSLISHRMFLPVMLS-LPKKAGWEKMLILIIDLFKFL 1773
XP_003959459 1727 FSSIKDVKirkELYTFDIEFYNISATYLHSFQPFAFPGFSFAWVSLISHRMFLPQILR-LPDKSGWEKLTLLIIDLFKFL 1805
CCE90120     1684 FIKVRNVVtrkELLDFDTEFYNIFSSYLQSAQPIAFPGFSFAWVTLISHRMFLPTMLR-LPNNAGWKNLMLLLIDLLKFL 1762
XP_002497191 1700 FIKIKDQKtrkDFISFDTEFYKIFSSYLHSLQPIAFPGFSFAWVTLISHRMFLPTVLR-LPEKSGWKSLTLLLIDLLNFL 1778
CCH61566     1679 FIKVKNVDtrkELIEFEEEFYNIIAKFLHTIQPIAFPGFSFAWITLISHRMFLPIMLR-LENKSGWKSLTNLLIDLIKFM 1757
4C0D_A        517 APFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDML 596 
CCE64445     1609 DQYTEKEGISNAISVVYKGTLRVMLGISNDQPEYLIENHYELLSHLTASYVQLKNVILSAVPKKMFIPNPYNPQLEMKDI 1688
XP_001643066 1438 DQYTGKVGISNAISVVYKGALRVIIGISNDFPEYLIENHYEFMNALPSSYAQLKNVMLAAIPKKIMLPNPYDNGLDMDKI 1517
CCC70050     1780 NQYTIKGKISDAVSVVYKGTLRIFLGISNDVPQFLIENHYELMNNLPISYFQLKNVILSAIPLKMLVPNPFDSDLALENI 1859
CCD26596     1807 DQYTIKGNISDAISVVYKGTIRIILGISNDVPDFLIENHYELMNNLPATYIQLKNVILSAIPLKMLVPSPYGVELDVDAL 1886
CCK72050     1774 DKYTKKDSVTDAVSVIYKGTLRIILGISNDFPEFLIENHYQLLNNLPCSYFQLKNVVLSAIPTKMCFPNPYNPTLQLSNL 1853
XP_003959459 1806 DQYTKRGIVSDAISVVYKGTLRVILGISNDVPDFLIENHYELMNNLPATYFQLKNVILSSIPKKKIVPNPYDPNLNMADV 1885
CCE90120     1763 DKYTDKNEVSNAISVVYKGALRVFLGISNDMPEFLIENHLELMNNLPPTYFQLKNVILSAIPKKMMLPNPYDPTLSLEDI 1842
XP_002497191 1779 NQYTHKNEIPNAVSVVYKGVLRVLLGISNDVPEYLIENHHELMNNLPSTYFQLKNVILSAIPKKMVLPNPYDPGLSMANI 1858
CCH61566     1758 EQYTDKNSIPDAISVVYKGALRVFLGISNDVPEYLIENHYELMNYLPPTYLQLKNVILGAIPKKMMIPNPYDPDLSMENI 1837
4C0D_A        597 SEINIAPRILTNFTGVMppQFKKDLDSYLKtRSPVTFLSDLRSNLQvs--------nePGNRYNLQLINALVLYVGTQAI 668 
CCE64445     1689 EDCQKNPSVFYDPVLDLh-VFKKPVDNYLR-IPSNSLFKTILNAVHkkeyvmkngvgyDYVAVDTKLVRAIVLHIGVEVG 1766
XP_001643066 1518 DSCKMQPTVFYDPVVDLh-SFKKPVDNYLR-IPSNSLMRTIINGVYrdeysfksgigyDYVSVDQKLVRAVVLHVGVEAG 1595
CCC70050     1860 TECQNPPVVFYDPVSDIq-ALKKPVDNYLR-IPSNSLLRTIINGLYlteydikggvgfDMLTTNNKLIRAIVLHVAVEAG 1937
CCD26596     1887 ESCEEPPMVFYDPVADIa-SLKKPVDNYLR-IPSNSLLKTIMNGLLredyelksgigyDTLTVNSKLVRAIVLHVVIEAG 1964
CCK72050     1854 ESCQECPSVFYDPINDLs-TLKKPVDNYLR-IPSNSLLRTILGSVFrseydvrngvgfDFLSVDSKVVRAIVLHVGVEAG 1931
XP_003959459 1886 ELCQQKPSIFYDPVKDLq-SLKKPVDNYLR-IPSNSLLKAILNGLYrteydvkigvgyDYLSIDNKLVRGVVLHVGIEAG 1963
CCE90120     1843 AACKEPPKVFYDLIAEFs-TLKKPVDNYLR-IPSNSLLKTIISNTYrneyelkngigyDYLSVDNNIVRAIVIHVGIEVG 1920
XP_002497191 1859 DLCQEPPKVYYDPVNDLk-SLKKPVDNYLR-IPSNSLLRTIVSGLYrteyemrngvgyDYFTTDMKLVRAIVLHVGLEAG 1936
CCH61566     1838 ESCQQQPNIFYNPVNDLk-TLKKPVDNYLR-IPSNSLLRIIIASLFkdvyerkngigyEHLMVDSKLIRAIILHVGIEVG 1915
4C0D_A        669 AhihnkgstPSMStiTHSAHMDIFQNLAVD--LDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEAN-TEA----- 740 
CCE64445     1767 IdnektssnVIFN--TKSSYYTLLFDLINE--GSVELKSQLTEAIVEQLRYPNIHTYWFSYVLKQFFYSQDw--Gektse 1840
XP_001643066 1596 LesektssgAIFN--AKSSYYTLLFNLLNE--GSSEVRFKVIEAMMEQLRYPNIHTHWFTFVLKNMFTSEEw--Geqkse 1669
CCC70050     1938 LengrtssnAVFN--TKSSYYQLLFDLIHD--GTIELKFQVIQVMIEQLRYPNIHTRWFIYVLRDMFVTEAw--Eeqrte 2011
CCD26596     1965 LengrtssnAVFN--TKSSYYQLLFDLVHE--GSIELKFQVIQVMIEQLRYPNIHTRWMIFVLKNMFTSEGw--Sdekst 2038
CCK72050     1932 LenertssnAVFN--PESSYYTLLYNMIHD--GTAELKFQVIEVMVEQLRYPNIHTYWFNYVLLNMFTSKDf--Gdqiae 2005
XP_003959459 1964 LenertsssAVFN--TKSSYYTLLYNLINE--GSTELRYQILQVMLEQLRYPNIHTYWFSYVLLNMFTSKEf--Gsnise 2037
CCE90120     1921 SeyqrmsssAVFN--TKSAYYTLLFNLIHD--GTVELQYQVIQAMVEQLRYPNVHTYWFIFALRNMFVSEEw--Gdqlle 1994
XP_002497191 1937 LenqkmsssAVFN--TKSSYYTLLFNLIHE--GVTELKYQIIQVMIEQLRYPNSHTYWFSYALKNMFVSDDw--Geqrse 2010
CCH61566     1916 IenertsssAVFN--TKSSYYSLLFNLINNdtTTIELKYQIIHTIIEQLRYPNIQTYWFNFVIINLFVSDEwSDGnkkqe 1993
4C0D_A        741 IQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLF 794 
CCE64445     1841 IQEIILRNLLERIIVNKPHPWGVTVLFTELLHNKDTKLIDLNCVKSVPEIEKII 1894
XP_001643066 1670 IQEIILRNIFERIIVNKPHPWGVTVLFTQLLNLNNVKLLSLPCVKKVPEIENIL 1723
CCC70050     2012 VQEIILRSLLERVIVHNPHTWGVSVLFTQLLNSDEVNLLELDFINNIPEIKHMF 2065
CCD26596     2039 VQEIILRSIIERILVNKPHPWGLSVIFTQLLRSDKVKLLELDFIKRVPEIENII 2092
CCK72050     2006 VQELILRCILERIIVNKPHPWGVSILTTQLLNQDEVNLLELEFIKTVPEIEKML 2059
XP_003959459 2038 IQEIMLRCLLERVIVNKPHTWGIIVFFTQLLQNKEVNILELDFIKNIPEIENIL 2091
CCE90120     1995 VQEIILRNLLERIIVNRPHTWGISVIFTQLITSKEINLLDLPFVKKLPEVRNLL 2048
XP_002497191 2011 VQEIILRNLLERIIVNRPHAWGVSVLFSQLLRGKDVNLLELPFVEKFPEINVIL 2064
CCH61566     1994 IQELILRNILERIIVNKPHCWGIIVLVMSLLKSSEVDLLSYSFIKEIPEVENMF 2047
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