5ZXA


Conserved Protein Domain Family
FAP
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pfam07174: FAP 
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Fibronectin-attachment protein (FAP)
This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.
Links
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Statistics
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PSSM-Id: 429334
Aligned: 7 rows
Threshold Bit Score: 280.274
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5ZXA_A            1 MHQVDPNLTRRKGRLAALAIAAMASASL---VTVAVP-ATANADp--ePAPPVPTTAASPPStaaa--------ppaPAT 66  Mycobacteriu...
P46842            1 MNQVDLDSTHRKGLWAILAIAVVASASA---FTMPLP-AAANAD----PAPLPPSTATAAPS---------------PAQ 57  Mycobacteriu...
VBC:MMAR_2737     1 MHEVDPNKRRRHGLWTTLALAAVSSASV---VSIALP-ATASADp--aPAP-APSTTAAPPAdpna--------appPAD 65 
AAS03886          1 MDQVEATSTRRKGLWTTLAITTVSGASA---VAIALP-ATSHADpe-vPTPVPPSTATAPPAapapngqpapnaqpaPGA 75 
WP_023985848      1 MDQSDVNSSHRRRRTAGLLAAAAAGATA---AALTLPvAVSHAEp--vPAPPPPVPAEPAPApgtp--------apaPGA 67  Mycolicibact...
tigr:MSMEG_3618   1 MYESDSMSHRRSGLSKKLTLAAVTGMTA---VAVALP-SVAHAD----PEPPPPPP-GNTFLpapp--------padPNA 63 
WP_011780282      1 MDQPDMHAKRRKGLPTSFRRSALTGATAaltAVFTLP-AVAYAQpappPSPAPPPAVEAPPVppp---------pvdPNA 70  Mycolicibact...

5ZXA_A           67 PV----APPPP-------------------AAANTPNAQP----GDPNAa-pPPADPNAPPP-PVIAPNApqpVRIDNPV 117 Mycobacteriu...
P46842           58 EI----ITPLP-------------------GAPVSSEAQP----GDPNA---PSLDPNAPYP-LAVDPNA---GRITNAV 103 Mycobacteriu...
VBC:MMAR_2737    66 PNa---PPPPP-------------------ADPNAPPPPP----ADPNApppPPADPNAPPP-PVVDPNApepGRVNNAV 118
AAS03886         76 PApngqPAPAA-------------------PAPNDPNAAPppvgAPPNGappPPVDPNAPPP-PPADPNA---GRIPNAV 132
WP_023985848     68 PA----PTPLP------------------------PGVPPp--pADPNA---PPVDPNA----PP--PPApepGRVDNAA 108 Mycolicibact...
tigr:MSMEG_3618  64 PA----PAPAPapapapapapalapapapgAPAPAPAPAPa--pADPNApapAPADPNAPAPaPAEEPPApepGRVDNAA 137
WP_011780282     71 PV-----PPPP-------------------VDPNAPVPPPp--pVDPNApvpPPADPNAPVP-PA--Pe---pGRIDNAA 118 Mycolicibact...

5ZXA_A          118 GGFSFALPAGWVESDAAHFDYGSALLSKTTGDPPFP----GQPPPVCNDTRIVLGRLDQKLYASAEATDSKAAARLGSDM 193 Mycobacteriu...
P46842          104 GGFSFVLPAGWVESEASHLDYGSVLLSKAIEQPPVL----GQPTVVATDTRIVLGRLDQKLYASAEADNIKAAVRLGSDM 179 Mycobacteriu...
VBC:MMAR_2737   119 GGFSFVVPAGWVESDASHLDYGSALLSKMTGEPPMP----GQAPPIANDTRVVLGRLDQKLYASAEATNPKAAVRLGSDM 194
AAS03886        133 GGFSYVLPAGWVESDASHLDYGSALLSKVTGPPPMP----DQPPPVANDTRIVMGRLDQKLYASAEANNAKAAVRLGSDM 208
WP_023985848    109 GGFSYVVPEGWRVADATQLSYGQALLTKI---PPAG----TEQP--ANDTSVLLGRLDLKLFAGSEADNAKAATRLASDM 179 Mycolicibact...
tigr:MSMEG_3618 138 GGFSYVVPEGWQVSDATQLSYGQALLTKT---VAEG----AEPP---NDTSVLLGRLDLKLFAGAEPDNNKAAVRLASDM 207
WP_011780282    119 GGFSYVVPAGWEVSDSTQLSYGQALLTKL---PPEGappdAQPP---NDTSVLLGRLDLKLFAGAENDNTKAAQRLASDM 192 Mycolicibact...

5ZXA_A          194 GEFYMPYPGTRINQETVSLD-ANGVSGSASYYEVKFSDPSKPNGQIWTGVIGSPAANAPDAG--PPQRWFVVWLGTANNP 270 Mycobacteriu...
P46842          180 GEFYLPYPGTRINQETIPLH-ANGIAGSASYYEVKFSDPNKPIGQICTSVVGSPAASTPDVG--PSQRWFVVWLGTSNNP 256 Mycobacteriu...
VBC:MMAR_2737   195 GEFFMPYPGTRINQETIPLN-ANGITGSASYYEVKFSDESKPNGQIWTGVVGTPAGSTPNEG--PPQRWFVVWLGTSNDP 271
AAS03886        209 GEFFMPYPGTRINQDSTPLNgANGSTGSASYYEVKFSDASKPNGQIWTGVIGS-----ANGG--NAQRWFVVWLGTSNDP 281
WP_023985848    180 GEFFMPFPGTRLGQESAPLT-AGDLTGSASYYEVKFTDTNKPNGQIWSGVVGTPVAAGT-RGqrAPERWFVVWLGTANNP 257 Mycolicibact...
tigr:MSMEG_3618 208 GEFFMPFPGTRVNQQTVQLN-ADGMPGVASYYEVKFTDANKPAGQIWAGVVGQPVAPGTPRGqrTPERWFVVWLGTANNP 286
WP_011780282    193 GEFFMPFPGTRVNQQVVPLD-N---NGVASYYEVKFTDTNKPNGQIWAGVVGEPVAPGTPRGqrTPERWFVVWLGTATNP 268 Mycolicibact...

5ZXA_A          271 VDKGAAKALAESIRPLVAPPPAPAPAPA 298 Mycobacterium tuberculosis H37Rv
P46842          257 VDKGAAKELAESIRSEMAPIPASVSAPA 284 Mycobacterium leprae TN
VBC:MMAR_2737   272 VDKGAAKVLAESIRPWM-PPPAPAPAPG 298
AAS03886        282 VDKVAAKALAESIQAWT-PPAAPPAAPG 308
WP_023985848    258 VDKAAAVNLAQSIRPWSPPPPPPPPDPN 285 Mycolicibacterium neoaurum
tigr:MSMEG_3618 287 IDKDAAVALANSIRPWAPPPPPPPAPAD 314
WP_011780282    269 IPQAEAVTLANSIRPWTPPPPPPPADPN 296 Mycolicibacterium vanbaalenii
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