Conserved Protein Domain Family
DUF4435

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pfam14491: DUF4435 
Protein of unknown function (DUF4435)
This presumed domain is functionally uncharacterized. This domain is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 285 and 362 amino acids in length. This domain is sometimes associated with AAA domains.
Statistics
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PSSM-Id: 433988
Aligned: 13 rows
Threshold Bit Score: 144.433
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:ACWZ:HMPREF0669_01740.1  27 ERIVAYVESY--DDvS-FWRNILDAY----EN-D--K---RY-FEvmlps-------------hqnlTKGKKQVLAN--L 77 
WP_012267297                 19 QDRFLLLEGA--DD-E-DFFTIICNL----LK-K--N---EA-QIsaeklyllkkiiidtaeriqgeLGNRAKIEKIcdL 83  ...
Q81GE3                       46 eTIFCFYEGK--DD-FkYYPTRIRTWlelhSN-N--K---SL-FSk--------------------gCGNRDKVIKVynK 95  ...
WP_015891863                 30 DAVFCFVEGE--DS-K-YYAAKIESI----EP-SykY---HF-IN----------------------SKGKEGVLKLfrL 74  ...
wustl:cce_2015               31 LALFCFFEGK--DDsK-YYSVRIDLI----VK-P--Id-dNY-FP----------------------CGKKSEVLRThsL 76 
jgi:Desal_1655               21 NGIDIFVEDTavGF-KkLYLILFKRV----FE-Gi-YnieNI-YP----------------------LGSRSAVVNRc-Q 69 
Q3IBX0                       20 ADVMVYVEGE--DDvP-FWEVVFNRL----VEyR--V---EV-QE----------------------VGGSKELAKYidE 64  ...
WP_013064467                 27 RRIVAYVESY--DD-IyFWRTVLSEF----EN-D--K---RY-FEvmlps-------------kinlTRGKKSVLMNflE 79  ...
CDA65584                     27 RKIVAYVESY--DD-VfFWRSVLGKF----EN-E--K---RY-FDi--------------------mLPTRNQHLDRgkK 72 
wustl:BV1919                 27 RKIIAYVESY--DD-IsFWRTLLGEY----EN-E--T---RY-FEvmlps-------------kttlAKGKKSVLMN--E 77 
WP_005857298                272 RKPILFIEGT--DT-NsIDSKLYPFI----FP-D--Y---LV-KP----------------------MGGCQKVIETtkA 315 ...
Q12VI0                       22 RGSVLIIEGSt-DM-R-LYQRFVD------DK-R--C---KV-IP----------------------ANGKENAIKVvqI 63  ...
Q8ZMQ7                       12 RKIFFTLEGE--SD-IrFLNTHFA------DE-R--I---HYdSP----------------------CSGKPEVINAvqL 54  ...
WGS:ACWZ:HMPREF0669_01740.1  78 L---QEN--MGEHMIACVDADY----------DYL------LQGvtptsrtvVNNAFVLHTYAYAIENLQCYAPSLHRLC 136
WP_012267297                 84 VaqePPD--VNNRVLGFVDREFrefecsndlkDHI------KTH--------KINKRLIWSRGHSIENYFFEISTLRKAF 147 ...
Q81GE3                       96 IkfdFEE--IDDVSLYFIDRDF----------NKE------NN----------LGKRIYVTPCYAIENLYAKETVLEKFL 147 ...
WP_015891863                 75 ItgiSEY--DLIKTLYFVDRDF----------DEL------I-----------DNPHIYETPCYSIENLYTTKNTICRVL 125 ...
wustl:cce_2015               77 IteqEYY--NHAKTAYFIDKDF----------DES------IYKtl----daDNASKIYETPCYSIENFYTSSYCFKRIL 134
jgi:Desal_1655               70 Id-qRRD--NPRPRLYVVDGDL----------NLL------HGNw------dVPWDGLYQLPRYCIENFLLDEQAILEIL 124
Q3IBX0                       65 L----EL--GKLQGIIACDSDF----------EIL------KGS--------LPNPNIIRTYGYAIENSLICQSTILKVI 114 ...
WP_013064467                 80 G----EP--LGRDMIACVDADY----------DYLmqgrthQSQr------iLNSPYVFHTYVYAIENFQCYAPSLHNVC 137 ...
CDA65584                     73 AaisSMLkgVGRDMIACVDADY----------DYL------RQGstessqqmLENPYIFHTYAYAIENFQCYARGLHETC 136
wustl:BV1919                 78 L---GPR--LGQNMIACVDSDY----------DYL------LQGathtsryiINNKYVFHTYAYAIENYQCYAEALHEVC 136
WP_005857298                316 FgqlKDF--HTLDSKGIVDRDR----------RTQ------GEin------yLREQHIYVPDVAEVENLLMIEDVIKTVA 371 ...
Q12VI0                       64 L---KRS--KIEGILTIVDADFwk-------vDG-------IRN---------ESSDVLVTDTHDLETMLIASEALERLL 115 ...
Q8ZMQ7                       55 L---RSH--GKQNVYGLCDADF----------DIL------EGN---------SYENIHFTDCHDLEMMLIEGGSFDKFI 104 ...
WGS:ACWZ:HMPREF0669_01740.1 137 VMAt-LNDr-----------nSF-NFEQFLESYSRII--YPLFVwniWHY-RKL-----KYKDFSMSdlL-SIid----- 189
WP_012267297                148 NDYl-VSSfyq--------eaFE-IFESKFEHTLRIA--CALSL---AGS-SEE-----LVKPIAKS--V-NW------- 196 ...
Q81GE3                      148 ESHiyINSksigkdlkdyciiRE-YYVQNLFEKLTQI--ALINAwysIQI-NKK------IEDLKNGgeI-SL------- 209 ...
WP_015891863                126 QREfqLDEtddd-----yytaLH-AFSTHQSEFHDAM--DQINAwiaCHR-DLS-----K-QGITTR--L-NL------- 180 ...
wustl:cce_2015              135 RSEftIDEiddn-----fdtcLD-LYENRQNEFHEKV--GLLNAyiaCLM-KKD-----E--QEKLD--LkSK------- 189
jgi:Desal_1655              125 DEEd--pEqtled----lriqFD--FVNWISANKELM--VNLFIeyaVSIvLTP-----EEKTISLG--V-NE------- 179
Q3IBX0                      115 RSVgkVPAknipnq--elniwLN-YFTQI-------M--NNLVIy--dAH-NE-------LN--GLG--I-SV------- 160 ...
WP_013064467                138 VSVt-LNDhr----------iFD--FRDYFQQFSEAI--FPLFVwsvMVY-RNG-----NYS----R--F-SItdfcria 189 ...
CDA65584                    137 VMVt-LNDrr----------iFD--FERFLESYSRTI--WPLFLwhmLFY-VRH-----RKMSMHFDm-A-EF------- 186
wustl:BV1919                137 VMAt-LNDhp----------lVD--FVAFMRMYSQIA--YPLFIwsvWFY-RKHnlsefSLLDFCSY--V-KL------- 190
WP_005857298                372 KRLmkDPDdvf-------kqvKEnVVRLFQKELDSQV--ILHAK---HQV-RKK-----LETTVDRK--I-TT------- 423 ...
Q12VI0                      116 EEFt-SPYk-----------vEA-LHMPIRQLLLYTAmpLGLFRwlsSS------------GKDKLS--L-RF------- 160 ...
Q8ZMQ7                      105 SEFlkTSIl-----------rIH-TLEDIRNNLKESI--IDVTYk--IGI-LKW-----LNFKNNLL--L-MF------- 152 ...
WGS:ACWZ:HMPREF0669_01740.1 190 ------lGSIDLRNV-SKSl--EQVELRVN--KKVESLQQhlpH-AL-------KE-YEELKEQLHRLgvNK-DNT---- 244
WP_012267297                197 -------QCIDITSTsLKI---DLEEWGKIl-NKKHKLDQ---L-RI-------QKlFNKFEVYLNMT--NQ-CDI---- 247 ...
Q81GE3                      210 -------DLKKLKSL-SDIkksTSVEEFSE--IDIEMLREitdN-PY-------EVtEEEIELELRHI--K--GDI---- 263 ...
WP_015891863                181 -------SDLNPSNL-VTV---SLTGVTQK--YSFDSLIEmfpH-AA-------EIdQETLENKLRSF--RS-IDR---- 232 ...
wustl:cce_2015              190 -------HNKLMKWF-I-I---ELDKIKSN--YNLETLNNefsP-KN-------NPsQQDINKELNYL--RS-QDC---- 240
jgi:Desal_1655              180 -------LKSDSSGI-VDHv-kTIERINF---IKQRTIEKvgeD-SY-------SIvKEEIASIVG-D--EN-IML---- 231
Q3IBX0                      161 -------VGDNCSRF-FKSq--KSHEV-CE--VKVNDFIAnigFsVC-------QSeIENITNLIGGI--P--RDL---- 212 ...
WP_013064467                190 dpggfsvQN-PAASI-NNV------KRKVR--TKINDLQRqfpD-AK-------DE-YLRTKDDIRAL--GV-TPQ---- 243 ...
CDA65584                    187 -------DKVIMLPS-VRI---QDPKWAID--YLGKKVRAklfQ--LerrfkkfKDeLDDMALYLNSLgvNE-SNT---- 246
wustl:BV1919                191 -------DRVSVYHL-ER----SLESMSRRvrRKLLELERrhpK-AL-------EE-IEAMKGEFAKLgvNE-DNT---- 244
WP_005857298                424 -------VEQLTEHV-ESI----RLNIHVE--EIYKNIKEefeS-YI-------ET--ENYKSILRVY--NQ-KGMlpqs 476 ...
Q12VI0                      161 -------KDVDFDHF-MEV---QPLSINIK--HLIREVKVnshG-DS--------LnERAIRKKLMKMl-NEdHDP---- 213 ...
Q8ZMQ7                      153 -------KGMKYDNF-ITFv-dFSANIDID--NYIQHILDrspR-KPp------HCdFNFLKKEYQLLynKQ-ADY---- 209 ...
WGS:ACWZ:HMPREF0669_01740.1 245 -Y---LYIQGH--FLFDNI-VlPLLKQVCAEL---RTeR 273
WP_012267297                248 -EtsrWLSHGHigFNFMFVvY-SKCLYITASD---LS-D 280 Microcystis aeruginosa
Q81GE3                      264 -L---SNSRGK--YIEEIL-I-ELYKKIIDET---NLpt 291 Bacillus cereus ATCC 14579
WP_015891863                233 -Q---KWYRGK--FELFFF-K-KFIEILSEDS---NR-R 259 Brevibacillus brevis
wustl:cce_2015              241 -Q---KSFRGK--FEIEFL-R-KFLEKLKEEA---NKkK 268
jgi:Desal_1655              232 -V---KYASAK--DYLFPL-L-KIYLRNKKCE---IKhT 259
Q3IBX0                      213 -S---DFIRGH--FLFSAV-S-KFISASIKQI---NS-K 239 Pseudoalteromonas haloplanktis TAC125
WP_013064467                244 -Tt-yLYIQGH--HLFDTV-V-SPILSKVCNLl--RQeR 274 Prevotella ruminicola
CDA65584                    247 -Y---LYIQGH--HLFDLV-V-SPIVQSVCDA---LR-N 273
wustl:BV1919                245 -Y---MFIQGH--HIMDSV-V-MRLLVPVCNV---LR-R 271
WP_005857298                477 rL---CAICGI--SNKESY-L-NLILSILKEN---KE-D 504 Parabacteroides
Q12VI0                      214 -W---QICSGH--DVVEIL-A-FGLREIFGNSdahHT-N 243 Methanococcoides burtonii DSM 6242
Q8ZMQ7                      210 -K---YVCNGHd-FTYITM-M-AFHSEFSRDK---NI-T 237 Salmonella enterica subsp. enterica serov...
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