Conserved Protein Domain Family
MMS19_N

?
pfam14500: MMS19_N 
Dos2-interacting transcription regulator of RNA-Pol-II
This domain, along with the C-terminal part, pfam12460, is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly.
Statistics
?
PSSM-Id: 433995
Aligned: 125 rows
Threshold Bit Score: 150.781
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EEH55676                   53 MESALVT-TEDARRARGVLLLAESvagyasgapdgaddASRSP-R----------PLPASAANLLSQYFTSKLDDFAVVR 120 
CDY45923                   48 MDMYLTT-TDDVVRARGILLLAEM--------------LDYLKsK----------PLDNAVVNSLVGFFTAKLAEWRSVR 102 
ERN15159                   49 MEVYLTT-TDASVRSRGILLVAEL--------------LSYLAsK----------PIDGAIIHSLTEFFTSRLADWQALR 103 
XP_018674225               49 MEQYLTA-SDHVIRARGILLLSEV--------------LSRLLeK----------PLDSRTVSSLVEFFTSKLEDWQALR 103 
Q6ZEY8                     51 MEMYLTT-TDHIVRSRGILLLGEI--------------LCRISfK----------QLDVNAISTLSDFFISRLSDWQALR 105  J...
WGS:AAFB:cds.EHI_129310A   42 LGDTLPS-EDERIRFRATSLLTYC--------------LIKY-------------PIKEESKDVFVDYLASRLVDAVCLE 93  
Q4DE17                     43 msRYLTD-EKHIIEALFVLSLATT------------------RrK----------TLLDEEAVVVLKFFLEKLSSLQTIE 93   T...
Q57YW3                     40 MGKYLTG-EEHVVNAVRVLGLATV------------------NrR----------DRTIEEVDVMLRFFSRKLSSMQTIA 90   T...
EFC46140                   55 LGEYLNHaTDDRIRGAAYAVLDLI--------------LENIPnNvgsetdetkqTTQLKLVASLLRFIGDRFYDFDCLA 120 
XP_001013640               64 MQFYFVN-GREKTRQRATEFIYLF--------------FSRYSgL----------QMSQEEVESLYLFFLTKLFDVATVK 118  T...
EEH55676                  121 AALLGCAAML-----------------------RArvsvspeegtnpgsvphadpgamttttnpKTTPAVTrlaALDMAD 177 
CDY45923                  103 GALTGCLALIr----------------------RK-----------------------------GVAGVVTavdAEAVAK 131 
ERN15159                  104 GAFIGCLALLr----------------------RK-----------------------------SHTGTISdndLINLTK 132 
XP_018674225              104 GALIGCLALLk----------------------RT-----------------------------KKFGMVEsndAKSLAE 132 
Q6ZEY8                    106 GALVGCLALLh----------------------RK-----------------------------RTVGSIIiadVKRLLE 134  J...
WGS:AAFB:cds.EHI_129310A   94 PILTALLQLV------------------------------------------------------TKKPSDE------IIN 113 
Q4DE17                     94 TSVECITRVIeylssq------------rpcskIV-----------------------------FTE----------LAN 122  T...
Q57YW3                     91 VAVESTALLVrelsse------------gpctsDV-----------------------------FNV----------LHT 119  T...
EFC46140                  121 TLLPCLFSLF-----------------------KKw---------------------------sSYISSEQ---AINVVL 147 
XP_001013640              119 TANKVLLELLknvikhqeqmkqkidskkagafkEF-----------------------------KFN----------LAK 159  T...
EEH55676                  178 RFF-----DAVHVPS--------LVQADRQRSYELLIALL--SH----AGAaDepdavgpPLGTstpSEqLECVVAACDG 238 
CDY45923                  132 SMA-----QSVQVQS--------LALYDRKLCFELLECLLe-EYp---EAMiN--------LGD---LM-VYATCEAIDG 182 
ERN15159                  133 SFL-----LNIQVQA--------LALHDRLLCLELLECLLd-QFp---SVIsV--------LDD---EL-VYGVLAAIDE 183 
XP_018674225              133 SFL-----RNVQVQS--------LAVRDRKLCFEVIQRLLd-VYp---QAVvE--------LGD---DL-VYGICEAIDE 183 
Q6ZEY8                    135 TFL-----QNVQVQS--------LAAADRKLCFQILNYILd-HYp---EAVkT--------MGD---EL-LYGMCEAIDE 185  J...
WGS:AAFB:cds.EHI_129310A  114 EIAma--ySCMRTQL--------YTKEVRILVYQFYKVFI---NyyqaTEV-------------------IDTCVQLIEL 161 
Q4DE17                    123 GFL-----PNVRLQA--------LPTRVRRSGFKILKYMVseA-----------------TVSWlttPV-LCLLLEAMDE 171  T...
Q57YW3                    120 EFL-----QSFSLQA--------LPTNVRSWGYDVLRFTVtkE-----------------TATWfttPF-LQVVLKSMDE 168  T...
EFC46140                  148 QFF-----ENVNIQSigstsgvaHATKTRSLCFEWFSLLAd-RFpsivRTI----------------DF-LNGFIQSLEG 204 
XP_001013640              160 QFIekisdSKFNISQ--------YSQDVRDSVYINLRFLQe-NFtescVELgA--------------TY-VKVIIESTED 215  T...
EEH55676                  239 EKDPRCVLLVCELFQALPRAF-------CgaegddaralskldahraafaAAAETLYDVVAAYFPVSFRPP-PGDV-VRV 309 
CDY45923                  183 EKDPPCLMVAFHVVELLARLFpspsgpvA---------------------SEASDLFEFISCYFPLHYTHT-KGDE-ASI 239 
ERN15159                  184 EKDPRCLMLVFHVVELLVQVFpd--------------------------psVAKDAFDILGRYFPIYFTRP-NVDA-IDI 235 
XP_018674225              184 EKDPRCLMLTFSLVGTLGRLFpdpsgpmG---------------------NFSSDVFDILSRYFPIYFTHS-KGDG-LDI 240 
Q6ZEY8                    186 EKDPECLKLSFNLVEAVMKLFpdpsglaA---------------------QYASEVFEILSKYYPIYFTHG-VGDD-LDA 242  J...
WGS:AAFB:cds.EHI_129310A  162 ERDPECLKEVFDLIKLVSQKNe-----iDa--------------------DSAPLLFDCASAYFPILYPPK-GDEA-LRI 214 
Q4DE17                    172 EGEPELVLHMFELYYFLSFFVd-----kNni------------------vPLKEQYFDSISSYFPVVFSRP-PG---CSV 224  T...
Q57YW3                    169 ENEPELLMRALELHHIIASYAr-----eDam------------------qPLLEEYFDSISSYFPVVFSQP-PG---CKV 221  T...
EFC46140                  205 ERDPGNLLYCFNLIPKVIAIFd-----dSelss-------------kilsAVSDDLFDITSCYFPITYTPP-ANDT-RGI 264 
XP_001013640              216 EKDPRCIIKSFKLIRFVLENFs-----lSml------------------kPFLEDIFDNLECYYPIDFQPDpEQDKkYQI 272  T...
EEH55676                  310 THEQLAATLRGAMCASSAYAPWAVPHVLESVDGsKPGLVVDDALAALAACGSAF---GRRAMAPHMRATWGALRRVLLN 385 
CDY45923                  240 PREDLSRGLSLAISSTPFFEPYAIPLLLEKFSS-SLPVAKVDSLICLKDCAVNY---GVNRMKKHYEGIWSAIKDALYa 314 
ERN15159                  236 KREDLSRRMMNAFSSSPLFEPFCIPLLLEKLSS-SLEMAKLDALKYLSHCAPRY---GPSRMASHAYAIWSALKDVIFN 310 
XP_018674225              241 TRDDLSKALMDAFSSSPLFEPFVIPLLLEKLSS-SLPSAKLDSLKYLNSCLRHY---EADKVVKHSQVIWSNLKDVIFN 315 
Q6ZEY8                    243 TRDDLSKALMHAFCSTPYFEPFAIPLLLDKLSS-SLPLAKLDSLKYLDNCIRCY---GADRMGRHVITIWFKLKEVIFS 317  Ja...
WGS:AAFB:cds.EHI_129310A  215 ---DLTNKILDAFVSAPIYAQFALPFLLDKLDA-DLSSIKLEALKAIYFCIQRF---ELKYVYAYFTHIWESIEQNIst 286 
Q4DE17                    225 TREELKRSLTRCMTC-PLYLDPCVSFTLSRLSS-PSSFVKQESIAVLLELFSPEsahDMNDLSPHILPVVSHVRNEVIk 301  Tr...
Q57YW3                    222 SKEDLRRVLSACMTH-PLYLNICVPFLLSRMAS-PSSVVKQESTNALLNIFSLDsshTTESLCPHVVSVTNHIRNEVvr 298  Tr...
EFC46140                  265 TREDLSRSLKLCFGCNKFFAPTLFPFLLEKLSS-DLVDTKLETLDYLCYCIEKF---GEVNSREYLTEIWSYIKAESVk 339 
XP_001013640              273 SPKDLSEALDLCLINKHILQK-TLDIINEKINS-SYIDAKLAAMQTYQLVFKNY----------LPGQLLSSQRKQILN 339  Te...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap