4Q2C


Conserved Protein Domain Family
HD_6

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pfam18019: HD_6 
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HD domain
This HD domain is found at the N-terminus of Cas3 enzymes fused to a helicase domain. This domain is sometimes found as a separate protein. It acts as a nuclease that cleaves ssDNA.
Statistics
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PSSM-Id: 436216
Aligned: 143 rows
Threshold Bit Score: 114.462
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4Q2C_A         40 WAKWGSGPDLg---WHPLLCHXLDVAAVTLQXWRRVLPAawkarISGVL---------GVGQEDAERWLAFFAGGHDIGK 107  Thermobaculum...
WP_011937758   11 WAKTTPEGKP----GISVYDHMLNVGCVARCIAETSPKI-----LERFHle--------------sSMVGALAALHDLGK 67   Geobacter ura...
jgi:Sfum_2824  10 WGKTSGNV------VHPAVCHMLDTGIVACELLMVQPHGfi-skLADEF---------GITTDALPQLAAFLAALHDIGK 73  
KGO33327        8 WGKADRNGPS----WHPAVCHMIDTGIVAKEILAVQPINfq-lqLTSPF---------QNAGQNALDVLAFVSAIHDIGK 73  
Q0AA29         24 WGKLHKGPAGeveaWLPLADHCTDVAFVFLALCRTNA-------AHRALsqa----igHAPTPVHLERLAALAFLHDIGK 92   Alkalilimnico...
EHM12583        6 WAKFDKKDPTr---WHSLLGHSADVAAVTERLLQLPL-------WRRRLsraasgsgwQSGIGALADRLCAYAALHDFSK 75  
WP_009164672   10 WGKFDVESGR----KQPLVAHLTDVAAVFEQIMDGAL-------FQRHFqrv----lgRPLSETLRERLCVLALWHDYGK 74   Pyramidobacte...
KWT98067        9 WGKAHPLPGTtv-aWHPLAYHSLDVAAVVGEYLRVNPSLss--tLARLL---------GMAEDAAIKVAMFLAGSHDVGK 76  
WP_011955426   12 WGKTPRPGTPvt-qFHPAIFHMLDVACVAEALLRHGPQR-----VRQALlha----wrGADPEALISWLPFLIALHDLGK 81   Roseiflexus s...
Q0W588         11 WAKSDP--------FHPLLYHMIDAGNVALSLLQTPafkvvgdkFSKAT---------GCPREACDVWLAYLVAMHDIGK 73   uncultured me...
4Q2C_A        108 ASPAFQLQL-------------RPEQGRElvarrlrdaglplfnARAPHGTISANVletvlad-------------vfgl 161  Thermobaculum...
WP_011937758   68 ISPGFQRKCdawleeyglniiaRNGCWDTame---------sdhGKISHAAIHAFLietg-------------------m 119  Geobacter ura...
jgi:Sfum_2824  74 ISPGFQAKRpdlsaplklegyvFSRA------------------DEDRHTLSTLETlpdllid-------------clqc 122 
KGO33327       74 ISPGFQQKSkdlceclkhrgftFPQT------------------SEPKHGRVALVVlkkslqe-------------mfgc 122 
Q0AA29         93 CNHGFQAKArre------------------------------prDTAGHVHEISALlydpdlqkrlldslgfdeiaswfd 142  Alkalilimnico...
EHM12583       76 LSAQFRLKKekdqh--------------------------gdfyKGVDHITTACDLvlrmdqeaayrgk----------- 118 
WP_009164672   75 ISPKFQLKYrekie-------------------------kltpkRSINHIDTAFNL------------------------ 105  Pyramidobacte...
KWT98067       77 FGP-FQAKVeelfaqlqpdqpvPSQ-------------------AAQHHSQAGISTlldwvsarw--------ypdsled 128 
WP_011955426   82 LSAAFQGQDeaqrerltragvqFRSHS-----------------PELHHAAISALWihdylaqne--------------- 129  Roseiflexus s...
Q0W588         74 CDPNFQLLNdgyaailreqgmpFPSEPD----------------KKFRHERSSSEWvrglle--------------eaew 123  uncultured me...
4Q2C_A        162 sgRSAR---------------------------WVAFAVGGHHGfVPSYDEVRRDLDQQAVGWGxwda------------ 202  Thermobaculum...
WP_011937758  120 drKTAK---------------------------FASAVLGAHHG---------------RLTPPndrgyrpqklisdsas 157  Geobacter ura...
jgi:Sfum_2824 123 edSLAI---------------------------ALSRALAAHHGvftgqeaqkv-------------------------g 150 
KGO33327      123 siEEKN---------------------------ALARVLAAHHGvfdeslsldv-------------------------g 150 
Q0AA29        143 daEGTL---------------------------GMLLASISHHG-KPIKLDHTETNRYrrywlprdg------------- 181  Alkalilimnico...
EHM12583      119 ---------------------ipelvdwdcddsvFLRILLSHHGrTPSRKKLrlhwpllwpda---------------rk 162 
WP_009164672  106 --SSIRykgkiwnelldvmhfwenedqkrilhdYLTWVILAHHGaVPTQERCDMAQDNSSRKCWergvnld--------- 174  Pyramidobacte...
KWT98067      129 aeLALE---------------------------PLLNASCGHHG-RPVDLSNSTGVGKRTTAAAh--------------- 165 
WP_011955426  130 ------------------------peiaqdlvwIFRDATGGHHG-RFVDESMEDLRKKLHYVERgesrw----------- 173  Roseiflexus s...
Q0W588        124 trRSRN---------------------------TISNSILLHHSrssdgellss-------------------------- 150  uncultured me...
4Q2C_A        203 ------areVLLCRLADALGlPGSSRPT----VESTPDAFXLAGLVSVADWIGSNeEYF 251  Thermobaculum terrenum ATCC BAA-798
WP_011937758  158 kidwdnerkENARMTWAHFSgSSAEFSL----SDDSPALWWLAGLTSVADWIGSDeRFF 212  Geobacter uraniireducens
jgi:Sfum_2824 151 agkwikarrAALEFLSRLFWdKSLTGLG----FPSTPALVILAGLVSVSDWLSSAeENF 205 
KGO33327      151 dhawqearrDILTLLARTFGiTSLASVR----LDNVPVLFLLAGLISVADWIASNeAIF 205 
Q0AA29        182 -idpledltNLTLTVRQAFPqAFTGDASp--lSPTPELQHRFAGLVMLADWIGSHeGFF 237  Alkalilimnicola ehrlichii MLHE-1
EHM12583      163 dapewtaleELRQSVKRWFPkAWGTDERm---PQAPLLGHFFAGVLMLADWIGSTeYFF 218 
WP_009164672  175 ---pqkalgELAALSQRWYPaAFAAGGGl---PEEPCFQHLFAGTLMLADWIASDrSLF 227  Pyramidobacter piscolens
KWT98067      166 ---------AYLDAVADVLGlDSFVDLWd--gGGYRQASSLLAGVLTLCDWVGSMqRFF 213 
WP_011955426  174 ----rdwrkQGYVLLRDLLApEDKPLHRigtpVAPRPATVALTGLLVWSDWIGSNeHDF 228  Roseiflexus sp. RS-1
Q0W588        151 peiwdtikrRLEEEIKRVFDyDNEPVDF----SDNSEAGLLLSGLIVLSDWIASNeELM 205  uncultured methanogenic archaeon
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