Conserved Protein Domain Family
MARF1_LOTUS
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pfam19687: MARF1_LOTUS 
MARF1 LOTUS domain
This is the LOTUS domain which is repeated in the C-terminal of of Meiosis regulator and mRNA stability factor 1 (MARF1) protein, an essential regulator of oogenesis required for completion of meiosis and retrotransposon silencing, key to maintain germline integrity. This domain provides RNA-binding properties to this protein, acting as an adapter to recruit targets for the effector domain NYN (pfam01936) at the N-terminal (RNase activity).
Links
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Statistics
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PSSM-Id: 437519
Aligned: 4 rows
Threshold Bit Score: 380.181
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
SMAX:SMAX5B_001581_1  749 MLSSEIICILQDAPASCLPLFKFTEIYEKKYSRKLAVGDLYRLPEVVTVREQGGSRLVCLLPSSQIRQSPLGSSQSQEGS 828 
XP_027324807          653 LLSSEAISILQDAPACCLPVFKFTEIYEKKFGHKLIVSDLYKLTDTVAIRDQGSGRLVCLLPSSQARQSPLGSSQSHDGS 732  mallard
XP_023620881          861 LLSGETMSILQDAPACCLPLLKFTDIYEKKFGHKLNVSDLYKLTDTVAIREHGNGRLVCLLPSSQARQSPLGSSQSHDGS 940  littl...
XP_006136349          611 QFSSETMTILQDAPACCLPIFKFTEIYEKKFGHKLIASDLYKLTDTVAIRDQGNGRLVCLLPSSQARQSPLGSSQSHDGS 690  Chine...

SMAX:SMAX5B_001581_1  829 SsASGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSYKIPFVVMSLSTLATEVHSLLQSHEGTLPLL 897 
XP_027324807          733 S-ANCSPIIFEELEYHEPVCKQHCLNKDFIEHEFDPDSYRIPFVILSLKTFAPQVHSLLQTHEGTVPLL 800  mallard
XP_023620881          941 S-TNGSPIIFEELEYHEPVCRQHCSNKDFSEHEFDPDCYQIPFVILSLKMFGPQVHSLLQTHEGTVPLl 1008 little brown bat
XP_006136349          691 S-ANCSPIIFEELEYHEPICKQHCLNKDFSEHEFDPDSYQIPFVILSLKTFAPQVHSLLQTHEGTVPLL 758  Chinese soft-she...
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