Conserved Protein Domain Family
TFP_LU_ECD_PATE1
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cd23577: TFP_LU_ECD_PATE1 
extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and similar proteins
PATE1 is a novel sperm-associated protein generally expressed in male genital tract and related to sperm development, maturation and fertilization. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467107
Aligned: 12 rows
Threshold Bit Score: 136.435
Created: 26-Feb-2021
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8WXA2        45 IVQCRMCHLQFPGEKCSRGRGICTAttEEACMVGRMFKRDGn---pWLTFMGCLKnCADVkgIRWSVYLVNFRCCRSHDL 121 human
NP_612151     45 IVQCRMCHLQFPGEKCSRGRGICTAttEEACMVGRMFKRDGn---pWLTFMGCLKnCADVkgIRWSVYLVNFRCCRSHDL 121 human
NP_001257318  44 IVQCRMCHLQFPGEKCSRGRGICTAtvEEACMAGKIFKKDGt---mWLKFMGCLKnCANVkkIKWGSYLVDFRCCRGHDM 120 Norway rat
NP_001186882  44 IVQCRMCHLKFPGENCTRGRGICTAtaEEACMAGKVFKRDGt---iWLNFMGCLKnCANVkkIKWGPYLVDFRCCRGQDM 120 house mouse
XP_003417528  63 TVQCRMCHIQFPGEKCSRGRGICTAdkNEACAVGRIYKKQRnlwsiWLIFMGCQRnCAEVekIKWSVYMVAFRCCRSADL 142 African savanna...
XP_023557305  44 IVHCRMCHLQFPGEKCMKGYGRCMAttEEACTVGKIFKTDGs---fWLTFMGCLKnCANVrnIPWSIYRVSFTCCRGYDL 120 degu
XP_030189549  23 IVQCRMCHLQFPGEKCSRGRGICVVtsEESCTTVRISKKDGt---pWLMFMGCLKsCANVgkIKWSVYLVEFRCCRGYDF 99  Canada lynx
XP_012864916  21 LIQCRMCHLMFPGEKCSRGRGVCTAtaEEACAIGMLYKADRt---lWLSFMGCLKnCANVqnIKWSVYFVTFKCCRGYDL 97  Ord's kangaroo rat
XP_020733361  43 MIQCRTCHIQFPRQKCSRGRGLCTAv-NEACTTGRIYKNDGt---lWLTFRGCLKnCANVndIRWSVYLVNFRCCRSHDL 118 Odocoileus virg...
XP_006878068  24 TVQCRMCYLQFPGEECSRGRGICNAdtNEACVVGKMYKKIGltydlWLTFKGCQKnCADAdnIKWNIYTVEFSCCRDSHL 103 Cape golden mole
XP_015978108  43 TIRCRTCHIQFPREECFTGRGVCAAksDEACVTGRIFKGDGs---pFLSFKGCQK-CANVngIKWSNYSVNLRCCKGYNL 118 Egyptian rousette
XP_007950319  23 TVQCRMCHLQFPEEKCSRGRGICNAdiNEACVLVNISRRAYll-dtWLAIMGCQKnCADVqmMHWGIYTVKFRCCRDSNL 101 Orycteropus afe...

Q8WXA2       122 CNEDL 126 human
NP_612151    122 CNEDL 126 human
NP_001257318 121 CNERF 125 Norway rat
NP_001186882 121 CNENF 125 house mouse
XP_003417528 143 CNENL 147 African savanna elephant
XP_023557305 121 CNENL 125 degu
XP_030189549 100 CNEYL 104 Canada lynx
XP_012864916  98 CNDDL 102 Ord's kangaroo rat
XP_020733361 119 CNDDI 123 Odocoileus virginianus texanus
XP_006878068 104 CNENL 108 Cape golden mole
XP_015978108 119 CNENI 123 Egyptian rousette
XP_007950319 102 CNEKL 106 Orycteropus afer afer
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