Conserved Protein Domain Family
DWORF
?
cd20247: DWORF 
DWarf Open Reading Frame (DWORF)
DWarf Open Reading Frame (DWORF) is a small protein that plays a key role in heart muscle contraction. DWORF, Sarcolipin (SLN), and myoregulin (MRLN) are transmembrane regulators of the sarcoplasmic reticulum calcium transporting ATPase (SERCA). DWORF enhances SERCA activity by displacing phospholamban (PLN), a potent SERCA inhibitor. This makes DWORF an attractive candidate for a heart failure therapeutic. DWORF is also present in slow-twitch skeletal muscle fibers.
Links
?
Statistics
?
PSSM-Id: 380779
Aligned: 52 rows
Threshold Bit Score: 40.0062
Created: 31-Jul-2019
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
P0DN84          1 MAEKGSTf-SHLLVPILLLIGWIVGCIIMIYVVFS 34   human
XP_027541683    1 MAEPAPAplSRLVVPVLLALGWILGCALMVYIVFS 35   saffron-crested tyrant-manakin
XP_025751617    1 MAEPAPAplSRLVVPVLLALGWLLGCALMVYIVFS 35   golden-collared manakin
XP_027633560    1 MAEPAQVplSHLVVPILLAVGWIVGCALMVYIVFS 35   peregrine falcon
XP_025009546    1 MAEPAQLplSRLVVPILLAVGWIVGCALMVYIVFS 35   chicken
XP_026710707    1 MAEPAQVplSRLVVPILLAVGWIVGCALMVYIVFS 35   burrowing owl
XP_027320353    1 MAEPAPVplSRLVVPILLAVGWIVGCALMVYIVFS 35   mallard
XP_025900920    1 MAEPAAVplSRLVVPILLGVGWIVGCALMVYIVFS 35   Nothoprocta perdicaria
XP_025952692    1 MAEPAEIplSRLVVPILLGIGWIVGCALMVYIVFS 35   emu
PKK23560     1694 MAEPAPVplSRLVVPMLLALGWIVGCALMVYIVFS 1728 rock pigeon
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap