1JAW,1MAT,1CHM,1B6A,1PV9


Conserved Protein Domain Family
APP_MetAP
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cd01066: APP_MetAP 
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A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.
Links
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Statistics
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PSSM-Id: 238514
Aligned: 102 rows
Threshold Bit Score: 62.4712
Created: 12-Aug-2003
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:human methionine aminopeptidase-2 complexed with fumagillin
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1JAW        181 IAVLRRAGEITAMAHTRAMEKCrpg-----------mfEYHLEGEIHHEFNrhgar-----ypsyNTIVGSGen--gcIL 242 Escherichia coli
1B6A        166 WNDFREAAEAHRQVRKYVMSWIkpg-----------mtMIEICEKLEDCSRklikenglnaglafPTGCSLNn----cAA 230 human
NP_065116   329 GMRRAHIKDAVALCELFNWLEKevpkg------gvteiSAADKAEEFRRQQadfv------dlsfPTISSTGpn--gaII 394 human
AAL48525      1 MRRIGLLNSLMRQKTTARNLFQ----------------FGKVKGDTGKYEQ--------------IVSTGQV------SP 44  fruit fly
BAB29167      5 RDRSQHGGAIGVPLLVRGGCQRilssplnhiylhkrsgSQQRRHFFFWRQRdi-----------sHSVVSPAav---sPA 70  house mouse
AAD27841      3 LADTRFATRRRALAAKLAAQRId---------------SILVTSPIHVRYL--------------SGFTGSNg----aLI 49  Corynebacterium ...
NP_372054     1 MSRITQVHRILEQKHLDAIIIL----------------SDYNRRYLSGFTGts-----------gALIISKDkqylitDF 53  Staphylococcus a...
ZP_00087307  55 LETMRHAQQLTWKAVDEIAKVIkp-------------gMRESEAHARGKEI--------------LVELGMDr-----IW 102 Pseudomonas fluo...
NP_578431     5 SEKPKVYVSATPKAHAEPFKDV----------------RIREGSVVSVVIGa------------dWNHYYAN------MT 50  Pyrococcus furio...
BAC15968      2 VLGVREVSISTAIDKPYISEYIq--------------sACNGRTGTNGGSRpp----------apALCVLYVwvw-ppTT 56  Japanese rice

Feature 1       #                                #                #                             
1JAW        243 HYTen----------------ecEMRDGDLVLIDAGCEYk------GYAGDITRTFPVngkf-----tqaQREIYDIVLE 295 Escherichia coli
1B6A        231 HYTpnag-------------dttVLQYDDICKIDFGTHIs------GRIIDCAFTVTFnp---------kYDTLLKAVKD 282 human
NP_065116   395 HYApvpe-------------tnrTLSLDEVYLIDSGAQYk------DGTTDVTRTMHFgtp------tayEKECFTYVLK 449 human
AAL48525     45 ERFvp-----------------eEIKKPAYYFKNMPPGNt------LGSPEIKSQVQId----------aMRLSGRLAAR 91  fruit fly
BAB29167     71 HPVp------------------kRIKKPDYVTTGIVPDW-------GDSIEVKDEDQIq----------gLREACRLARH 115 house mouse
AAD27841     50 VNKdl----------------saQICTDGRYTTQIGEEVpdiealiERASATTLLAQVeg---------pRRIAIEAAQT 104 Corynebacterium ...
NP_372054    54 RYIdqa---------------tkQAPNYEIINRKSTIIGei---keLLHQENFENIGFe----------gHHVSYDTYLE 105 Staphylococcus a...
ZP_00087307 103 HPLlirfgantlktfkersdgdpVLGENDIFFIDMGVVWe------GHEGDAGATYVTgsdpqmvacaaaSKELFDKVET 176 Pseudomonas fluo...
NP_578431    51 RYFp-------------------IGQMSERAKNAMDAMEe------AYAISVEKTRPGv-----------RFAQVEREIQ 94  Pyrococcus furio...
BAC15968     57 HPGlaglea---------vetleKLEDGDIVNVDVTVYYk------GVHGDLNETYFVgnv------deaSKQLVRCTYE 115 Japanese rice

Feature 1                                                                    #                  
1JAW        296 SLETSLRLYRPGt---sILEVTGEVVRIMVSglvklgilkgdvdeliaqnahrpffMHGLSHWLGLdvhdvgv----ygq 368 Escherichia coli
1B6A        283 ATNTGIKCAGIDv---rLCDVGEAIQEVMESyeveidgk----------tyqvkpiRNLNGHSIGQyrihagktvpivkg 349 human
NP_065116   450 GHIAVSAAVFPTgt-kgHLLDSFARSALWDSgldy-----------------lhgtGHGVGSFLNVhegpcgis---ykt 508 human
AAL48525     92 ILRECGKLATVGt---tTDQIDAFAHERILEskaypsplrya----gfpksictsiNNIACHGIPDd------------- 151 fruit fly
BAB29167    116 VLLLAGKSLKVDm---tTEEIDALVHWEIIRhdaypsplgyg----rfpksvctsvNNVLCHGIPDs------------- 175 house mouse
AAD27841    105 TLDQLDSLREAT-----QEDVELIPVSGVVEs------------------------IRLTKDSFELd------------- 142 Corynebacterium ...
NP_372054   106 LNKSRISLISIS-----NTVDKIRDVKDVDE-------------------------IALIQKAANIv------------- 142 Staphylococcus a...
ZP_00087307 177 FWRKGVTGVGLYr---yATDQAEAMGWKLNLdi----------------------kGHRVSDFPHA-------------- 217 Pseudomonas fluo...
NP_578431    95 KLYSSRGLGEYY-----ITGYTHGVGLLIEEdp----------------------iTTIVVPHRAM-------------- 133 Pyrococcus furio...
BAC15968    116 CLDKAIAIGDSFsfslvLVAIYLALCLGYVSlqll-----------------flnsKHMIAHLSEVf------------- 165 Japanese rice

Feature 1                     #                                                                 
1JAW        369 drsrILEPGMVLTVEPGLYIapdaev------------------------------------------------------ 394 Escherichia coli
1B6A        350 geatRMEEGEVYAIETFGSTgkgvvhddmecshymknfdvghvpirlprtkhllnvinenfgtlafcrrwldrlgeskyl 429 human
NP_065116   509 fsdePLEAGMIVTDEPGYYEdg---------------------------------------------------------- 530 human
AAL48525    152 ---rQLADGDIINIDVTVFLn----------------------------------------------------------- 169 fruit fly
BAB29167    176 ---rPLQDGDIINIDVTKPA------------------------------------------------------------ 192 house mouse
AAD27841    143 ----RLRDVAALASQAFEDLlaagelaegrser----------------------------------------------- 171 Corynebacterium ...
NP_372054   143 ---dETYEYILTVVKAGMTEke---------------------------------------------------------- 161 Staphylococcus a...
ZP_00087307 218 ----IYRGGNLGDFDQAPNAgv---------------------------------------------------------- 235 Pseudomonas fluo...
NP_578431   134 ----EAKENMVLAMVHAPLMi----------------------------------------------------------- 150 Pyrococcus furio...
BAC15968    166 ----VTFIGTSRQVSAQDHR------------------------------------------------------------ 181 Japanese rice

Feature 1                                    #          
1JAW        395 ------------------peqyrgIGIRIEDDIVITETGN 416 Escherichia coli
1B6A        430 malknlcdlgivdpypplcdikgsYTAQFEHTILLRPTCK 469 human
NP_065116   531 -----------------------aFGIRIENVVLVVPVKT 547 human
AAL48525    170 -----------------------gYHGDCSETFRVERGRT 186 fruit fly
BAB29167    193 ------------------------ISVKPVGVVFLLPRRA 208 house mouse
AAD27841    172 ------------qvaadleyrmrlLGAERPSFDTIVASGP 199 Corynebacterium glutamicum
NP_372054   162 -----------------------lKAILESKMLELGADGP 178 Staphylococcus aureus subsp. aureus Mu50
ZP_00087307 236 ----------------------wiLEIQIEHPELPYGAFY 253 Pseudomonas fluorescens PfO-1
NP_578431   151 -----------------------pEGAVKKEDTFILGRKL 167 Pyrococcus furiosus DSM 3638
BAC15968    182 ------------------------YTYQISNMSIRHKIEE 197 Japanese rice

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