4A4F,4A4H


Conserved Protein Domain Family
Tudor_SPF30
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cd20399: Tudor_SPF30 
Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins
SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410470
Aligned: 22 rows
Threshold Bit Score: 75.8061
Created: 24-Apr-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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peptide binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
  • Structure:4A4F; Homo sapiens SPF30 in complex with symmetrically dimethylated arginine at the peptide ligand binding site, contacts at 4A
  • Structure:4A4H; Homo sapiens SPF30 in complex with asymmetrically dimethylated arginine at the peptide ligand binding site, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #    # #                 #  # #               
4A4F_A         9 WKVGDKCMAVWseDGQCYEAEIEEIDeeNGTAAITFAGYGNAEVTPLlNLKPVEEG 64  human
ADF47428      48 WNKGDECQAMWmgDKHYYNAVIEDIYa-DGTCQVRFNKYTDKQICDLsSLKMKLAD 102 Dugesia japonica
PVD31943      79 WSVGDRCLAMFsdDGQYYEAVVEEILe-DGACTVTFSEYGNTDVTQVgMLKPIEED 133 Pomacea canaliculata
KFM81040      77 WNTGDKCLAPWseDGQYYEAVIEDITe-DGQCTVHFVAYGNTDVSDLeHLRPLDKE 131 Stegodyphus mimosarum
XP_013400333  80 WNVGDKCSAVYseDGMYYDAVIDEVLe-DGSCTVTFESYGNTDLTQVsLLKPRDSS 134 Lingula anatina
XP_019851715  68 WKQGDSCKALWskNGKHFNAVIDMISedGQTCTVTFDGYGTTEITRItDLMPRDWE 123 Amphimedon queenslandica
AAL28898      92 WKKGDKCQAKWkeDRQYYDATIEDISs-TGEVNVIFDAYQNRSTTHVnELRERTIR 146 fruit fly
EFX77898      75 WSVGDKCMAPWsnNKQYYDCTIEALSe-DGEVSIRFDAYGNSDVTTTdKLKERPRG 129 common water flea
OAF71925      71 WTVGDSCMALWegNNKYHAAKITEIGi-NETCTIMFDYYESTQQHDLsTLKPQRSQ 125 Intoshia linei
XP_004363701  65 WRLGDLCLGVWs-DGSYRDARIDGIAddRVTCTIAFDQGGTKMDVSVnSLRPRAAS 119 Capsaspora owczarzaki ATCC 30864

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