3SQ3


Conserved Protein Domain Family
Tyr-DNA_phospho

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pfam06087: Tyr-DNA_phospho 
Tyrosyl-DNA phosphodiesterase
Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyse the bond between topoisomerase I and DNA.
Statistics
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PSSM-Id: 461824
Aligned: 111 rows
Threshold Bit Score: 247.954
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3SQ3_A          6 KLMKSDFYEREdfmgEVEDMITLKDIFGTETLKRSILFSFQYELDFLLRQF-HqNVENITIVG----------------- 67   Saccharomyces...
XP_007296111  192 IVKKTWVNGMP----RHGDDIKIEEVLQKNDLELAVLSAFQIEPEWVESKLnQr--TKVIWVLqaktda------erqni 259 
XP_013946627  133 TVKRTWVRGTA----RRGDEITIEEVFQKDKLELAVLSSFQWDEEWMLSKLdYrR-TKILLLAfardgaqvlefihktlm 207 
EHK17742       80 TVKRTWSRGCA----RTGEEITIEEVFQKDQLELAVLSSFQWDEEWMMSKLdIrR-TKILLLAfakdea------qknlm 148 
XP_014169810  113 VVKKTWIRGQP----RGDDDITIDEVWQKSGLELAVLSSFQWDEEWMMQHVdVrK-TKLLLIAyaaden------qkvem 181 
EED12486      217 VVKKTWVFGCP----RNNNDIKIEEVLQTADLELAVLSAFQWDTEWLFSKFrTpGKTRFLMVMqakees------trlqy 286 
EEA18915      220 VVKKTWAFGYS----RNGDDIKIEEVLQTADLELALLSAFQWDMQWMFTKFrTpNKTRFLMVMqakees------trlqy 289 
GAD91435      216 VVKKTWALGYP----RDGNDTTIEEVLQKSDLELAVLSSFMWDMEWLFSKLdTrN-TRFLLVMqakeee------tkrqy 284 
XP_001270092  222 IVKKTHAQYCP----RMGDDITIEEVFQKDDLELAVLSSFIWDMEWFFSKLdTkH-SRFLLVMqakdda------tkrqy 290 
EED51309      224 VVKKTWAFGCR----RQGDDIKIEEVFQKSDLQLAVLSSFMWEMEWLFSKLnTaK-TRFYLVMqakdes------tklqy 292 
3SQ3_A         68 -QKGTIMPiearamdatlavilKkVKLIEITMP-PFASHATKLIINFYDNgECKIFLPSNNFTSMETNLpQQV------- 138  Saccharomyces...
XP_007296111  260 sSKAPA----------------N-YRFCFPNMEgNINCMHSKLQLLAHPT-HLRVVVPSANLTSYDWGE--TGimenicf 319 
XP_013946627  208 qGNVPA----------------N-IKFCFPPMHgV-GAMHSKLQLLKYPS-HLRVVIPTGNLMPYDWGE--TGvmenmvf 266 
EHK17742      149 rGNVPS----------------N-IKFCFPPMHgP-GAMHSKLQLLKYPD-RLRVVIPTGNLVPYDWGE--TGvmenmvf 207 
XP_014169810  182 rENVPNSN----------------VRFCFPPMLsV-GAMHSKLQLLKYAD-YLRIVVPTGNLVPYDWGE--SGtienmvf 241 
EED12486      287 qQETADMP--------------N-IRLCFPPMEgQIKCMHSKLMLLFHPD-YLRIVVPSANLVPYDWGE-QGGvmentvf 349 
EEA18915      290 qEETANMP--------------N-IRLCFPPMDgQVNCMHSKLMLLFHPE-YLRIVVPSANMVPYDWGE-QGGvmentvf 352 
GAD91435      285 eAETSYMK--------------N-LRLCFPPMEgQVNCMHSKLMLLFHPN-YLRIAVPSANLTSYDWGE--LGvmensvf 346 
XP_001270092  291 eAETASMR--------------N-LRLCFPPMDgQINCMHSKLMLLFHPE-YLRIVVPTANLTPYDWGE-MGGvmensaf 353 
EED51309      293 kSETAAMS--------------N-LRLCFPPMDgQVNCMHSKLMLLFHSG-YVRIVVPTANLTPYDWGE-IGGlmensvf 355 
3SQ3_A        139 CWCSPLLKI--------GKEGLPVPFKRSLIEYLNSY--HlkdidELITKSVEEVNFAPLSeLEFVYSTPSKFQSS---- 204  Saccharomyces...
XP_007296111  320 LIDLPRLPP--------GEKTVVTNFANELVYFVEQMglD-----QKTATSLQNFDFSRTAhLAFVHSIGGSHSGStwkr 386 
XP_013946627  267 LIDLPRLDHpvsthasaARSHAPTRFYTELVYFLQATgvG-----EKMVASLANYDFSRTAdLAFVHTIPGSHSAKnae- 340 
EHK17742      208 LIDLPRLGNpa-----tHPPQRPTGFYTELVYFLQSTgvG-----DKMVASLSNYDFSKTSdIAFVHTIPGSHSGNaakr 277 
XP_014169810  242 IIDLPRLPAq------aGRISGKTPFLDDLSYFLKAQavD-----QSLVQSLDNYDFSATArYAFVHTISGSHAKDswer 310 
EED12486      350 LIDLPKRSAq------dVPDTPKKAFYEELAFFLQAStvH-----NNIIAKLSSFDFKETSrYRFVHTIGGSHIGEcrrr 418 
EEA18915      353 LIDLPKKSTn------dAADSPKTAFYEELSYFLKAStlH-----ENIIAKLSAFDFKETNrYAFVHTIGGSHFGEsltr 421 
GAD91435      347 IIDLPKKQDq------tSTQTQETPFYRDLVYFLSAStlH-----ANVISKLDAFDFSETAsFAFVHTIGGSHAGSawrk 415 
XP_001270092  354 LIDLPRKSSt------lSSSDSKTAFLEDLVFFLSASrlH-----ENVIAKLGDYDFRETKhIMLVHTIGGSHIENfs-k 421 
EED51309      356 IIDLPKRTDk-------DSGFTRTGFYDELTYFLKAStlH-----ENIIAKLTDYDFSRTAhIAFVHTIGGSHMGDswrr 423 
3SQ3_A        205 -GLLSFYNKLEKLSAgtSAsdtakHYLCQTSSIG--TSLS---RARDENLWTHLMIPLFtgimsppakdtagrkk----- 273  Saccharomyces...
XP_007296111  387 tGYCGLGTAIKKLGM--ATev-dlNIEFLSASIG--SLND---------SFMECLYLAAqgddgateyrwrtekp----- 447 
XP_013946627  341 -----riASVADLGL--ASvd-pvDVDLVCASLG--ALNQ---------QMVRAIYNACrgddgtdeyhkpastssrssa 401 
EHK17742      278 tGYCGLGASVAALGL--ASpe-pvEVDLVARFFGlsTICGevaNSSTLPSLVGAIYNACrgddgiedykkssgts----- 349 
XP_014169810  311 tGYCGLGRAIKSLGW--ATee-plQLDYLCSSIG--SLGD---------DLLNALYYACqgdtgmkeyearan------- 369 
EED12486      419 tGHCGLGQAVSSLGL--RThe-piSIDFVTSSIG--SLTD---------EFMRSIYLSAqgddgsieytlrtsksfpt-- 482 
EEA18915      422 tGHCGLGKAVTSLGL--KTre-piNIDFVTSSIG--SLTD---------EFMRSIYLSAqgkqtlysiirtiilnvs--- 484 
GAD91435      416 tGLCGLGRAISSLGL--RTsk-plNIDFVTSSVG--SLTD---------QFLRSIYLACqgddglteftlrnsktfp--- 478 
XP_001270092  422 tGFCGLGRAVKALGL--STfk-siSIDYVTSSVG--SLTD---------EFLRSIYLACqgddgmtehalrttktmp--- 484 
EED51309      424 tGYCGLGRAVNSLGL--RTsk-plNIDFVTSSVG--SLTD---------EFLRSIYLACqgddgsteyvlrtaksfp--- 486 
3SQ3_A        274 ---aeilptnslineysqRKIKPYIIFPTEQEFVTSPLKWSSSGWFHFQY---LQKKSYYEMlrNKFkvfykqdpamvtR 347  Saccharomyces...
XP_007296111  448 --tkskgrsaaehkllgnVNSNCRIYFPTKETVEASRGGVTGGGTICLQSkwfDSDTFPRKLmrDCK------------S 513 
XP_013946627  402 kkpttttttatvtsqeqlLRERFRIYFPTDRTVSQSRGGRNAGGTICVQTkwwRAPNFPRELvrDVI------------- 468 
EHK17742      350 --srsraskkpaettskeLKDRFRIYFPTDKTVARSRGGRNAGGTICVQArwwRSPSFPTELvrDVI------------- 414 
XP_014169810  370 ----kpkkgvlasssepdWKSRMRVYFPSHQTVVRSRGGIRGAGTICFRRnwwESAKFPRKIlrDYQ------------N 433 
EED12486      483 kakqnteatdiqrttgseWKSRFRVYYPSEQTVVQSRGSRRCAGTICFKEnwfVGPKFPRNVlyDCV------------S 550 
EEA18915      485 crlggdgstnaqrttsseWKSRFRVYYPSEQTVSQSKGSRRSAGTICFQEkwfTGPKFPRNTlhDCI------------S 552 
GAD91435      479 aksrgdpnilikkdtgqeSKDRFRVYFPSDSTVRQSRGGPQCAGTICFQSkwfQGPNFPRYAlrDCV------------S 546 
XP_001270092  485 arpptttssillkpaaeeCKDRFRVYFPSQTTVEQSRGGPNCAGTICFQQrwyEGPKFPKHLlrDCK------------S 552 
EED51309      487 vrsrsnptqlinkstaeeWKDRFRVYFPSETTVNDTKGGPQSAGTICFQSrwyTGPKFPRHVlrDCV------------S 554 
3SQ3_A        348 RRGTTPAHSKF-YMHCAtnsagpcdaSQVfkeLEWCLYTSANLSQTAW-------------------------------G 395  Saccharomyces...
XP_007296111  514 VRKGILMHNKMiFARAr--------dQKQypkIAWAYVGSHNLSESAWyvtrpsvqlglaviltittwlatpswgfshmG 585 
XP_013946627  469 SRDRVLMHSKMiFVRRRpgds--gqaQAVrqsPGWAYVGSANLSESAW-------------------------------G 515 
EHK17742      415 TRDRLLIHSKMiFVRRVgd------gQATrqpPGWAYVGSANLSESAW-------------------------------G 457 
XP_014169810  434 VKKGTLAHTKLlFVRR-----------EAssaQAWTYLGSANLSESAW-------------------------------G 471 
EED12486      551 RREGLLMHNKMmFVRPEkpi----nlPEGsncAGWVYVGSANLSESAW-------------------------------G 595 
EEA18915      553 RREGLLMHNKMmFVRPEkpi----nlPGGsncAGWAYVGSANLSESAW-------------------------------G 597 
GAD91435      547 RRDGLLMHNKMiFARPDepi----tlADGsrcQAWAYLGSANLSESAW-------------------------------G 591 
XP_001270092  553 RRPGLLMHNKMlFVTPDepi----tlPDTsqcQGWAYVGSANLSESAW-------------------------------G 597 
EED51309      555 QRLGLLMHNKIlYVRPDdpa----tlPDNsqcRAWAYVGSANLSESAW-------------------------------G 599 
3SQ3_A        396 TV---------SRKPRNYEAGVLYHSRRLANTrkvt-------------crtfTRDRRGCAGNPTHVAVPFTLPVIPYD 452  Saccharomyces ...
XP_007296111  586 RLvkdratkepKLTLRNWECGVIVPIPAKVMAdngdcp----------rsnggVENSVGMEVFHSLIPIPMAVPGEVYE 654 
XP_013946627  516 RMskdkstggfKLVCRNWECGVIIPVPESQPVdkt---------------tlpTSADDDMSMFAGTVPVPMQVPGPVYR 579 
EHK17742      458 RLskdkstegiKMSCRNWECGVIIPVPESKTVd-------------------kTVASADMAMFAGTVPVPMQVPGPVYT 517 
XP_014169810  472 RLvkdratkepRLTCRNWECGVLIPAVPRPEAerra--------------nvpREGAGMLGEFDKSVPVPMVLPGTEYG 536 
EED12486      596 RIvqdrsrgepKLNCRNWECGVLVPITESSVSssssd-----------eekksSKDEDITQTFGSTVPVPMRVPAPILG 663 
EEA18915      598 KVvhdrvrkepKLNCRNWECGVLVPITELPPAagsdgeeqnk--dsakkedksGAEGDIVEIFGSTVPVPMRVPAPSLG 674 
GAD91435      592 RLvqnrttkepKLNCRNWECGVVIPIPQQGTKaetsgslgaasnekpsderknEKESDFAPLFETKVPVPMKLPGRPYG 670 
XP_001270092  598 RLvqdratkrpKLNCRNWECGVLIPVRAEATAenrpkesesk-pvdgldkpgeGEVERMLDTFKDTVPVPMRVPGQRYG 675 
EED51309      600 RLvqeratkepKLNCRNWECGVLMPVISKEDAvseqn------------kspnDESGTMLDAFKGIVPVPMRLPAPQYG 666 
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