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Coiled-coil domain-containing protein 124 /Oxs1 Oxs1 (oxidative stress transcription corepressor Oxs1) and Pap1 form a complex to regulate transcription when cells are exposed to diamide or Cd that causes disulfide stress. In fission yeast such as S. pombe, heterologous Oxs1-like proteins can enhance diamide stress tolerance. Furthermore, human and arabidopsis Oxs1 can interchangeably bind Pap1 or Pap1 homologs from human (cJun) and arabidopsis (bZIP10), suggesting that Oxs1 may be a component of an evolutionarily-conserved stress response pathway. Family members found in human such as Ccdc124 (Coiled-Coil Domain Containing Protein 124), were identified as a novel component of the centrosome during interphase and G2/M transition and is involved in cytokinesis. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",