2BID


Conserved Protein Domain Family
BID
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pfam06393: BID 
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BH3 interacting domain (BID)
BID is a member of the BCL-2 superfamily of proteins are key regulators of programmed cell death, hence this family is related to pfam00452. BID is a pro-apoptotic member of the Bcl-2 superfamily and as such posses the ability to target intracellular membranes and contains the BH3 death domain. The activity of BID is regulated by a Caspase 8-mediated cleavage event, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, which causes a change of cellular localization.
Links
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Statistics
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PSSM-Id: 428916
Aligned: 13 rows
Threshold Bit Score: 240.733
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2BID_A         5 CEVn-NGSslrdECITNLLVFGFLQSCSDNSFRRELDALGHElpv------laPQWEGY-------DELQTDGNRSSH-- 68  human
XP_005040440   1 MEQi-NGS----LQMEHALLFTFLDASSDCQFKDQLHSLHSPqi--------mSCQASDd------DELQTDGNRSGH-- 59 
Q8JGM8         3 QDIysNGS----DHMERMLLFAFLAESSGCEFQEQLPSLQSQgvlc---svkdALCYDSd------GELQTDGNRSGH-- 67  chicken
XP_012664777   4 EVSn-GSGlrdeHLTGLLVYGFLQSCSNSGFQRELEELGHEPfvrthllvrthLHEELDe-----dELQTDGSRASRF-- 75 
XP_008248351  12 PKVs-SGPgprdEHITNLLVLGFLQSCCSCSFHEELQVLGRElls------eaELADSYdccsyddDELQTDGNHASF-- 82 
Q4JHS0         3 SKVs-NGSslqdERITNLLVFGFLQSCPHASFHKELEVLGHElpv------htSGS----------DELQTDGNRCSY-- 63  pig
XP_010589079   3 ltVs-NGSglqnERITNLLVFSFLKNCPSCHFHEELAELSYElpl------paHLREEY-------DELQTDGNRNSHfh 68 
NP_001238867   3 SKVs-NGSgpqdERITNLLVFGFLQNCSNYNFHEELELLGRElpv------paYLKEDYd------DELQTDGNRCSY-- 67 
ELK02625      77 PKIs-NGArlqhEHITDLLVFGFLQNCCNSNFHKELKALGHDlpv------paYPREDYd------DELQTDGNRCSH-- 141
XP_005340634   3 SEVs-NGSdlrnEYITNLLVLDFLQSFSDCKFHQELRTLGQElpv------rtYLEGERe------DELQTDGNRAS--- 66 
Q9JLT6         3 SEVs-NGSglgaEHITNLLVFGFLRN-NDRDFHQELEVLGQElpv------qvYLEGDRe------DELQTDGSRASRs- 67  Norway rat
XP_003461816   3 akVg-NGAgtrgELVTDLLVFGFLCSRDNSNFHSELKALGQElpg------rpEV--DHd------DELQTDGNRLSH-- 65 
EHB13699       3 AKVg-NGAgfrdESITNLLVYSFLHTRNNSNFHPELEALGQElpv------gvCLEADHd------DELQTDGNRGSRl- 68 

2BID_A        69 --SRLGRIEAdSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEK 146 human
XP_005040440  60 --FQNGELEL-PPTNEEVIRIIAAQLAEIGDQFDKEIQARVVRDLVQHFVNERLSREEITLHLSRAVNKLLTSIPSDMAQ 136
Q8JGM8        68 --LQNGELVPdPEVNEAIVRTIAAQLAEIGDQLDKQIKAKVVNDLVQHFLNENLPREEITRCLSQAVEGLARAIPSDLEQ 145 chicken
XP_012664777  76 --YAERIEADsGSQEDVIQNFARRLAQIGDSMDRSIPPRLVNNLVQQFRNPSLSEENRRGHLAAALEQVMQTCPADLTEE 153
XP_008248351  83 --LQMGRAEAgSESQEEVIRNIARRLAQIGDRMDHHIQPELLNNLVVEFVN-DHSEEDRRRRLASAVEQAMETWPADMER 159
Q4JHS0        64 --FMEDAAETdSESQEAVIRDIARHLARIGDRMEYGIRPGLVDSLAAQFRNQSLSEEDRRQGLAAVLQQLVHSYPADMGQ 141 pig
XP_010589079  69 fqSFQGRLEQdSGSQEEVIQSIAERLAQIGDEMESQVHPSLVQNLARQFMDRNLSEEDRRKHLATAVDRVMQTCLLDMEL 148
NP_001238867  68 --FLDGGARD-SESQEEIIQDIARQLAQIGDRMDHSIHPGLVNNLAMQFMNVNLSEEDRRKHLAAALEQAMQTYPKDMEK 144
ELK02625     142 --IVLEREETeSENQEEIIQNIARQLAQIGDRMDSRIPPRVVNYLAMEFMNVDLSEEDRKDCLSAALEEVMKTYPKDMER 219
XP_005340634  67 --LFMGRIEAdSESQEEVIQNIARHLAQVGDEMDRSIQPELVNELVARFMNAGLSEEDRSNCLDTTLKAAMQTYPKDMEN 144
Q9JLT6        68 --FYHGRIEPdSESQDEVIHNIARHLAQAGDELDHSIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTSFPRDMEN 145 Norway rat
XP_003461816  66 --FHGGRREAdSESQEELIQHIASQLALIGDEMEHKIQASVVHQLSTQLRDSSLTPEGRRHCLAATLGEVMQTCPADVEQ 143
EHB13699      69 --LYGGRREGdSENQE-IIHSIAWHLAEIGDELDRSIQPGLVNQLAMHFRNPGLSEEGRRHYLAATVEEVMQTYATDMEQ 145

2BID_A       147 EKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARN 194 human
XP_005040440 137 EKAMLVLAMVLTKKIVNTMPSLLRRVYDATVNYMNQQFHDYIVEMLGE 184
Q8JGM8       146 EKAMLVLAMLLTKKVANQMPSLLQRVFSTTVNYISQHFHNYIVRMLRE 193 chicken
XP_012664777 154 KATLLLIMLLAKKVADHTPSLLPVVFRTTVNFINRNLLASVRNLARNM 201
XP_008248351 160 EKATLMLTMLLAKKLAEHTPSLLRAAFRAAVTLINQDLLAYVRNLAGN 207
Q4JHS0       142 EKTLLVLTMLLARKVAEHSPALLRDVFHTTVNFINQNLLTYLRNLVQS 189 pig
XP_010589079 149 EKKKLMLTMLLAKKVADHMPSLLRDVFRTTVNFINQNLLTYVRNLARN 196
NP_001238867 145 EKTMLMLAMLLAKKVADHTPSLLRDVFHTTVNFISQNLLTYVRNLVRN 192
ELK02625     220 EKTMLMLTMLLAKKVADHTPSLLRGVFHTTVNFINQNLLTYVRNLLRN 267
XP_005340634 145 EKTMLIMTMLLAKKVANHTPSLLHDVFRATVNFINQNLFTYVRDLVRN 192
Q9JLT6       146 DKAMLIMTMLLAKKVASHAPSLLRDVFRTTVNFINQNLFSYVRDLVRN 193 Norway rat
XP_003461816 144 EKAVLIMTMLLARKVADHTPRLFRVVYDTVVDFINQNLLTYVRDLVRN 191
EHB13699     146 EKAKLITAMLLVRKVADHTPSLLRDIFHTTVNFINQNLLTYMRDLIRN 193
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