Conserved Protein Domain Family
RMP

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pfam14996: RMP 
Retinal Maintenance
RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two types of retinal dystrophies: cone-rod dystrophy type 16 (CORD16) and retinitis pigmentosa type 64 (RP64). CORD16 affects the cone receptors which detect red, green or blue wavelengths of light and RP64 affects the cone receptors first and then the rod receptors. Both of these affect the photo-receptors in the eye leading to colour blindness or blindness respectively.
Statistics
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PSSM-Id: 464431
Aligned: 19 rows
Threshold Bit Score: 168.71
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003055089  90 IDGV---LGSGASTSARPPSGRpipiapRVADRGSERSAAVAVGGGGRAGGV---------RCAPCpSIAGARLPLGGPS 157
XP_002108953  57 LSRM---IEDICSVEDESDIEK------RRREVNKIAEKKSVTKQQSLDCSK---------RCYQV-YLGGSKSLIGLAT 117
XP_007228920  60 IEAV---LQEILDNDDDDDQTGssdipaTVRSHAKDSCPQTASK-----------------KCCPV-FLGGSLVTSGVGT 118
XP_003456480  64 IDAL---LEELQEEDCSHFPQPkaeqfpKGPHVEKTLPSQS--------GGR---------KCCPV-FIGGSFVANGVGT 122
XP_004078376  63 IDAL---LEELLEDKDTYSPQS-------KSQQNRPKETQVENKLSFQIGRR---------KCCPV-FVGGSSVTNGVGT 122
XP_009020914  11 LNKIeqkLDHKNKSFDSDSSAKknqnerRDEKKFRNSLSSYDFEDILNDGPAtddhdharrHSTAEkTLHHSYNYNRHHH 90 
EFC49909      99 LDDF---MNELIEDSPTSPIIKrknsipKNASVGAFTTSSPVSSLTSPRVSK---------KCSTT-YLSNRHDSFGINT 165
EEY54406      56 LDDL---LDMLGDEDSKPTAVHprpkssSRAGAYNSPDSKISRT-----------------ECPQV-LLDGGHASRGLST 114
EDO49219      52 LSDI---IRDICEDDGPDLPPVvppptgSPSSTPGLTAHKS--------------------KCFTL-LLGGTRFSKGLCT 107
EEN61022      53 LDAM---IDDICEAPEPLEPLVdkapaqNSPRTPRGAEGKR--------------------RCAVL-YLGGSKHAMGLGS 108
XP_003055089 158 SHFDa-----KACDAMRCTGCDFDVLSFERAAWRDGVDYMFFRNAYPDAGKLSAATATRRGGRAYCCQCSWRSAREEDVE 232
XP_002108953 118 ISSQ------RACNQLRCTACDFRVSYYDDYEWHQRSNYIFFRNNMPDFEKIRVNLLRKLGTRAYACQCSWKSIADVVPV 191
XP_007228920 119 SISQ------RACDQLRCTACDFGIAMFNDHEWDSSCDYLFFRNNMPDRTKLRAKLKRRQGARAYACQCSWYSANSLSEL 192
XP_003456480 123 AASK------RSCDQLRCISCDFRVLMFDDCEWDSTCDYLFLRNNMPERQKLRTKLKKRRGLRAYACQCSWISTLESTDL 196
XP_004078376 123 ATSK------RSCDQLRCVSCDFRVVMFDDCEWDQSCDYLFLRNNMPDCQKLRKKLKKKRGQRAYACQCSWFSASEPADL 196
XP_009020914  91 GSLKi-----RPCDNLRCTTCDFNVSSFDDMAWLEEVGYLFLRNNMPDFNRIKNKLKKSLGSRAYACQCTNLNVGDRI-L 164
EFC49909     166 FLTP------KRCSDLRCMKCDFKVINFDGKKWKEDVNYLFFRNNYPETVKKGFEEKEFPDHTSYCCQCSWITVSDRTSA 239
EEY54406     115 AFSSrhaysfSSCSNLRCNECDFTVVQFPGKKWDASVDYMFFRENVPSEAKLRVKMEIAPDFTAYACQCKWLSICSQTRM 194
EDO49219     108 VSEQ------RTCDKLRCTSCDFKVVVFDNYAWDGDCDYLFFRNNVPDFHKLKVKLKTRKGTRAYACQCCWRSIVDLMDL 181
EEN61022     109 SMNQ------RSCDQLRCTDCDFRVVFYDNYEWDASCEYLFFRNNVPDFGKLKAKLNKRKGSRAYACQCKWTSVQDLVDI 182
XP_003055089 233 EikaMSGTLRWVCGGH 248
XP_002108953 192 D---NYTDLKWVCGRH 204
XP_007228920 193 R---HNPQLKWVCGQH 205
XP_003456480 197 R---DQPQLRWVCGKH 209
XP_004078376 197 R---DQPQLRWVCGKH 209
XP_009020914 165 PlkiASPSVKWVCGKH 180
EFC49909     240 K---NLTSLNWYCGGH 252
EEY54406     195 D---N-CQVKWSCAGH 206
EDO49219     182 Q---TDATLKWVCGKH 194
EEN61022     183 Q---KKTDFKWVCGKH 195
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