Conserved Protein Domain Family
BSP_II

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pfam05432: BSP_II 
Bone sialoprotein II (BSP-II)
Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts. The expression of bone sialoprotein (BSP) is normally restricted to mineralized connective tissues of bones and teeth where it has been associated with mineral crystal formation. However, it has been found that ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone.
Statistics
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PSSM-Id: 461651
Aligned: 14 rows
Threshold Bit Score: 160.04
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003773007  17 FSVKNLYRRAKLGDSEENGVLNHRHRYYIYKYSYLYPPLKRipVQRNGDSSEE-GDGESSEEEEEEE-ENsneeEETES- 93 
XP_003221343  17 FSVKSFRRRFKADDSEENAVFKNRFWPFFYRQPYLYPPMKR--QQFNSDSSEEgYGGNSSEEEEEEE-AG----PSNEE- 88 
Q28862        17 LSMKNLNRRAKLEDSEENGVFKYRPQYYVYKHGYFYPALKRfaVQSSSDSSEEnGNGDSSEEEEEEE-ETsneeGNNGGn 95  cattle
P31936         1 FSMKNFHRRAKLEDPEENGVFKYRPRYYLYKHAYFYPPLKRfpVQSSSDSSEEnGNGDSSEEEEEEE-ENsneeENNEEn 79  pig
2_pfamImport   1 FSMKNLHRRVKPEDSEENGVFKYRPRYYLYKHAYFYPALKRfpVQSSSDSSEEnEDGDSSEEEEEEE-ETsneeEKDENs 79 
XP_002815004  17 FSMKNLHRRVKIEDSEENGVFKYRPRYYLYKHAYFYPHLKRfpVQGSSDSSEEnGD-DSSEEEEEEE-ETsnegENNEE- 93 
XP_004870614  17 LSMKNLHRRFKLEDSEENGVFKYRPRYYLYKHGYFYPPLKQfaVQGNSDSSEEnGNGDSSEEEEEED-ETsneeENNEDs 95 
XP_008265839  17 FSMKNLHRRVKLQDSEENGVFKFRPQYYLYKHAYFYPPLKRfpVP-SSDSSEEnGEGDSSDEEEEGE-ETsneeENNEDs 94 
XP_003515346  17 FSMKNLHRRVKAEDSEENGVFKYRPRYFLYKHAYFYPPLKRfpVQGGSDSSEEnGDGDSSDEEGE-E-ETsneeENNEDs 94 
XP_005341956  17 LSMKNLHRRIKLEDSEENGVFKFRPRYYLYKHAYFYPPLKRfpVQGSSDSSEEnGDGDSSDEEEEEEeTSne-eENNEDs 95  thirteen-lined ...
XP_003773007  94 ---NGSEes------tTLSATTLGYGEENttasgdiG-LAAIQNPK------------------K---EEK-NNQVTKKE 141
XP_003221343  89 ---NEGEqek---eeaTKAPSEPATGDKK-------G-VSDSKPPKqvpvkkeplgkpgkeggaKkaeKDKaPEKGGKEE 154
Q28862        96 edsDENEdeeseaentTLSTTTLGYGE-ItpgtgdiG-LAAIWLPR------------------K---AGAtGKKATKED 152 cattle
P31936        80 edsDGNEdedseaeniTLSTTTLGYGGDVtpgtasiG-LAALQLPK------------------K---AGDiGKKSAKEE 137 pig
2_pfamImport  80 ---NGGRyltrefkalEKSATM-GEGVLQvqghgrmGsELSFCFSF------------------Q---AGDmRKQATKKE 134
XP_002815004  94 ----SNEdedseaentTLSATTLGYGEDAtlatgypG-LAAIQLPK------------------K---AGDiTSKATKEE 147
XP_004870614  96 ---NGNEdedseaentTLSTITPGYGEETtpgtdyiG-LAAIQLPK------------------K---AGDiGNKATKKE 150
XP_008265839  95 ---NGNEdeeseaensTLSFTTPDYGE-ItrgtgyiG-LAGIKLPK------------------K---AGAiENKATEEE 148
XP_003515346  95 ---EGNEdeeaeagntTLSSVTASYGAETtteagsiG-LAALQLPK------------------K---AGDaESKAAKNK 149
XP_005341956  96 ---NGNEdeeseaentTLSATTPGYGEEVtpgtgnmG-LAAIQLPK------------------K---VGDlGNKATKKK 150 thirteen-lined ...
XP_003773007 142 ESDEEEEEEE-----ENEESEaEVDENKEGGNSTNHENAEGDHGNGNGGk----EEGEEEEEVENgteaten---easns 209
XP_003221343 155 EEDSDENEEEeneeeENEEQE-KVDENGNGVNGTSTNSTAEENGNGGKG-----EEEEEEEENEA--------------- 213
Q28862       153 ESDEEEEEEE------EEENEaEVDDNEQGINGTSSNSTEVDNGHGSSGgdngeEDGEEESVTEAntegi-------tva 219 cattle
P31936       138 ESDEDEEEEE-----ENEENEaEVDDNEQGTNGTSTNSTEVDSGNGHSGgd-ngEEGDQESVTEAqgttvage--qdngg 209 pig
2_pfamImport 135 ESDEEEEEEEee-enENEENEaEVDENDQGVNGTSTNSTETENGNGSSGgd-agEGGEGDSVTgeta-----------gt 201
XP_002815004 148 ESDEEEEEEEee--nENEESEaEVDENEQGINGTSTNSTEAENGNGSSGgd-ngEEGEEESVTGAnaegttatggqgkgs 224
XP_004870614 151 ESDEEEEEEEn----ENENNEaEVDGNEQAVNGTSTNSTEVENGNGSSGad-ngEEGDKESVTEAntpgttmsagqstgs 225
XP_008265839 149 ESDEEEEEEEe---nENEENEaEVDENEQSINGTSSNSTEAENGEAGEG----------ESVTATdaagtatrgewisra 215
XP_003515346 150 ESDEEEEEEE-----ENENEEaEVEENEQVANGTSANSTEAYGGNSSSGgd--nGEGEEQSVTEAgvegttldreqisdg 222
XP_005341956 151 ESDEEEEEEE-----ENEENEaEVDENEQGINGTSTNSTEVENGNGSSGgdnreEEGGQESVTRAnvrgttq---qnngg 222 thirteen-lined ...
XP_003773007 210 teVTTSLNG-YE---FTTLLKGDFEVTS-PPYEESTSNLYdsGY----------EEPVTNEYDNGYEV---YE-NENREP 270
XP_003221343 214 --TTIVPTTlFTtvvPTTEYQDQYDTTTeEQWHAETTPEDqwQYdtttedpwvhDTTTTTGYENGYETqtdYYgSENGYP 291
Q28862       220 geTTTSPNGgFK---PTTPHQEVYGTTP-PPFGKITTPg---EY----------EQTGTNEYDNGYEI---YE-SENGDP 278 cattle
P31936       210 akTTTSPNGgLE---PTPPPQDISGTTL-PPSGKTTTPEYegEY----------EQTGAHEYDNGYEI---YE-SENGEP 271 pig
2_pfamImport 202 rgQTTSPNGgFQ---PTTPPPEVYGTPS-PPSGKTTTFEYeeEY----------EQTGTNEYDNGYEV---YD-SENGEP 263
XP_002815004 225 skTTTSPNGgFE---PTTPPQ-VYRTTS-PPFGKTTTVEYegEY----------EYTGANEYDNGYEI---YE-SENGEP 285
XP_004870614 226 skTTPSPNGvFE---PTTPAPEVYGSTP-PPYGKTTTAEYgaEY----------EQTGANEYDPGYEV---YD-NENGGP 287
XP_008265839 216 aeTTTAPSGgFE---PTTPPPEAYGTTS-PPFGKTTAAEYggEY----------EQTGNHGYDDGYEI---YE-NENGDP 277
XP_003515346 223 ptTAVLPNG-FQ---YTTPPPEAYGTTA-PPFRKPTTAEYwgEY----------EQTGNNEDNGEYQI---YD-NENGEP 283
XP_005341956 223 ykTTTPQNGgFQ---PTTPPPEVYGTTS-PPFGRTTTVEYegEY----------EQMGTNEYGHDYEV---YD-NENGEP 284 thirteen-lined ...
XP_003773007 271 RGDNYRAYEDEYSYYKGHAYNGYgGQDYY 299
XP_003221343 292 RGDTFRAYEDEYSYYKGHGYDVY-GQDYY 319
Q28862       279 RGDNYRAYEDEYSYYKGRGYDSYdGQDYY 307 cattle
P31936       272 RGDSYRAYEDEYSYYKGRSYNSYgGHDYY 300 pig
2_pfamImport 264 RGDTYRAYEDEYSYYKGQSYDGYeGY-YY 291
XP_002815004 286 RGDNYRAYEDEYSYFKGQGYDGYdGQNYY 314
XP_004870614 288 RGDNYRAYEDEYSYYKGRGYDGYdGQDYY 316
XP_008265839 278 RGDNYRAYEDEYSYYKGRGYEGYeGQDYY 306
XP_003515346 284 RGDTYRAYEDEYSYYKGRGYEGYdGQDYY 312
XP_005341956 285 RGDTYRAYEDEYSYYKGQGYGGYdSQNYY 313 thirteen-lined ground squirrel
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