Conserved Protein Domain Family
STKc_PSKH1

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cd14087: STKc_PSKH1 
Catalytic domain of the Protein Serine/Threonine kinase H1
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PSKH1 is an autophosphorylating STK that is expressed ubiquitously and exhibits multiple intracellular localizations including the centrosome, Golgi apparatus, and splice factor compartments. It contains a catalytic kinase domain and an N-terminal SH4-like motif that is acylated to facilitate membrane attachment. PSKH1 plays a rile in the maintenance of the Golgi apparatus, an important organelle within the secretory pathway. It may also function as a novel splice factor and a regulator of prostate cancer cell growth. The PSKH1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270989
Aligned: 6 rows
Threshold Bit Score: 460.462
Created: 26-Jul-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #            # #                            #               ####
P11801        96 AKYDIKALIGRGSFSRVVRVEHRaTRQPYAIKMIETkyregreVCESELRVLRRVrHANIIQLVEVFEtqeRVYMVMELA 175 human
Q501V0        94 AKYDIKALIGRGSFSRVVRVEHRsTRQPYAIKMIETryregreVCESELCVLRRVrHTNIIQLMEVFEtaeRVYMVMELA 173 zebrafish
Q4KTY1        78 AKYDIKALIGRGNFSKVVRVEHRvTKQPYAIKMIDRvqg--keVFESEVAVLRRVkHSYIIQLIEVFEtkdKVYMVMELA 155 Pinctada fucata
NP_001017030  88 AKYDIKALIGRGSFSRVVRVEHKaSKQPYAIKMIETkcregreVCESELNVLRRVrHTNIIQLIEVFEsqeRVYMVMELA 167 western clawed ...
XP_788919     69 AKYDIKALIGTGTYSRVVRVEHRsTRQPYAIKMVEKkrd-gkqFWEVELTILRRVrHTNIIQLLEVYDgkdRIYMIMELA 147 purple urchin
NP_490820     69 CKYEVLAVVGKGSFSQVLRVQHRvTRKYFAVKVVNGdc----gAVNNELNILSRLsHPFVIRLEEVFKsssKLFIVMQMA 144 Caenorhabditis ...
Feature 1           # #                                   ## # ## #            ##  #             
P11801       176 TGGELFDRIIAKGsFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPgtDSKIIITDFGLASARKKg---DDC 252 human
Q501V0       174 TGGELFDRIITRGsFTERDATRVLQMVLDGVKYLHTLGITHRDLKPENLLYYHPgaDSKIMITDFGLASTRKKg---DEC 250 zebrafish
Q4KTY1       156 TGGELFDRIIAKGsFTERDATRVLNMVLDGVKYLHGLGITHRDLKPENLLYYHPghDSKIMITDFGLSSTRKG----PEN 231 Pinctada fucata
NP_001017030 168 TGGELFDRIITKGsFTERDATHVLQMVLEGVKYLHALGITHRDLKPENLLYYHPgiDSKIMITDFGLASAQKKg---DDC 244 western clawed ...
XP_788919    148 TGGELFDRIVTRGnFTERDATRVLHMVLDAMRYLHGLGITHRDLKPENLLYYHPgnESKIMITDFGLASFRKTtegsENN 227 purple urchin
NP_490820    145 SGGEMYDRVVAKGrYSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSrpEARLLITDFGLAYQATK----PNE 220 Caenorhabditis ...
Feature 1             ##### #                                                                    
P11801       253 LMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDnRTRLYRQILRGKYSYSGEPWPSvSNLAKDFI 332 human
Q501V0       251 LMKTTCGTPEYIAPEILVRKPYTNAVDMWALGVISYILLSGTMPFEDDnRMRLYRQILKGKYSFSGEPWPSvSNLAKDFI 330 zebrafish
Q4KTY1       232 FMRTTCGTPEYIAPEIIARKPYMCQVDMWAVGVITYILLSGTMPFDDEnKTRLYRLILKAKYSYAGEHWKDvSAQAKDFI 311 Pinctada fucata
NP_001017030 245 LMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVISYILLSGTMPFEDDnRTRLYRQILRGKYSYSGEPWPSvSNLAKDFI 324 western clawed ...
XP_788919    228 MMRTICGTPEYISPEILLRKPYTQSVDLWAIGVVAYILLSGRMPFDDDnRTRLYRKILRAKYSFTGDPWKDvSPAGKDFI 307 purple urchin
NP_490820    221 TMTETCGTPEYIAPELLLRVPYTQKVDMWAVGVIAYILMSGIMPFDDDcRSRLYTHIITANYVYYPQFWSG-SELAKQFV 299 Caenorhabditis ...
Feature 1                               
P11801       333 DRLLTVDPGARMTALQALRHPWV 355 human
Q501V0       331 DRVLTVDPNERLSAGQALKHPWI 353 zebrafish
Q4KTY1       312 DKLLVVSPGDRLSAADALKHQWL 334 Pinctada fucata
NP_001017030 325 DRLLMVEPGQRMTATHALKHPWI 347 western clawed frog
XP_788919    308 DKLLLINQSERMTATQALKHPWI 330 purple urchin
NP_490820    300 DSLLETNSVERLSSSAAMKHEWL 322 Caenorhabditis elegans

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