Conserved Protein Domain Family
SAM_DCase
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TIGR00535: SAM_DCase 
S-adenosylmethionine decarboxylase proenzyme, eukaryotic form
This enzyme is a key regulatory enzyme of the polyamine synthetic pathway. This protein is a pyruvoyl-dependent enzyme. The proenzyme is cleaved at a Ser residue that becomes a pyruvoyl group active site. [Central intermediary metabolism, Polyamine biosynthesis]
Links
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Statistics
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PSSM-Id: 273124
Aligned: 4 rows
Threshold Bit Score: 512.856
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P21182        28 FEGPEKLLEIWFFPHKKSi-tTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTT 106 Saccharomyces c...
O02655        25 FEGAEKLLELWFCSSTQN---ETRSLRIIPREEIDAMLDIARCKILHSKHNESIDSYVLSESSLFISDNRVILKTCGTTR 101 Caenorhabditis ...
P46255         8 FEGFEKRLEITFFEPSIFvdpEGKGLRALCKAQLDEILGPAECTIVDSLANESVDSYVLSESSLFIYAYKIIIKTCGTTK 87  spinach
NP_001053213  17 FEGYEKRLEITFSEAPVFadpDGRGLRALSRAQIDSVLDLARCTIVSELSNKDFDSYVLSESSLFIYSDKIVIKTCGTTK 96  Japanese rice

P21182       107 TLFCLEKLFQIVEQELSWafrttqggkYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNG----KSYSVGRND 182 Saccharomyces c...
O02655       102 LLAALPVIMQLAGAYAGL---------DQVQSVYYSRKNFLRPDLQPSLHKNFDAEVEYLDSFFVDG----HAYCLGSLK 168 Caenorhabditis ...
P46255        88 LLRAIPPILRLAGKLS-----------LDVKSVRYTRGSFIFPGAQSYAHRSFSEEVAVLDGYFGKLaagsKAFVMGDPA 156 spinach
NP_001053213  97 LLLTIPRILELAEGLS-----------MPLAAVKYSRGMFIFPSAQPAPHRSFSEEVAVLNRYFGHLksggNAYVIGDPA 165 Japanese rice

P21182       183 KSn-HWNLYVTETDRSTPKgkeyIEDDDETFEVLMTELDPECASKFVCGPEASttalvepnedkghnlGYQMTKNTRLDE 261 Saccharomyces c...
O02655       169 QD--RWYLYTFHREVEFPA----HKQPDHTLEILMSDLDEEVLHKFTKDYAVD---------------GNDCFMRAGIDK 227 Caenorhabditis ...
P46255       157 KPq-KWHVYSASAETIS-F----EE-PVYTLEMCMTGLKKEKASVFFKSQSPn---------------AAVMTESSGIRK 214 spinach
NP_001053213 166 KPgqKWHIYYATQHPEQ---------PMVTLEMCMTGLDKEKASVFFKTSADGht-----------scAKEMTKLSGISD 225 Japanese rice

P21182       262 IYVNSAQDSDLSFHhdafaftPCGYSSNMILA-EKYYYTLHVTPEKGWSYASFESNipvfdiSQGKQDNLDVLlHILNVF 340 Saccharomyces c...
O02655       228 IIPAGADVHDELFD-------PCGYSMNAYMNdTDQYATIHVTPEKAFSFASFETN------QDLVCLYSQTR-KVLQCF 293 Caenorhabditis ...
P46255       215 ILPD-SKICDFDFE-------PCGYSMNAIEG--PAISTIHITPEDGFSYASFEAVg----yDLKKTDLNQLVeRVLACF 280 spinach
NP_001053213 226 IIPE-MEICDFDFE-------PCGYSMNAIHG--SAFSTIHVTPEDGFSYASYEVVg----fDASTLAYGDLVkRVLRCF 291 Japanese rice

P21182       341 QPREFSMTFFTKNYQ-NQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI 396 Saccharomyces cerevisiae S288c
O02655       294 RPNKILMTVFANDISeKGKDAQQQLWDRELPGYRRTNVQFVRLETETLVYAHFVRKA 350 Caenorhabditis elegans
P46255       281 EPSEFSIAIHAEIA--ANSMEHNCYVNVNGYSREEGGIEELGFGAASVFYQKFCKAS 335 spinach
NP_001053213 292 GPSEFSVAVTIFGGH-GHAGTWAKELNADAYKCNNMVEQELPCG-GLLIYQSFDATE 346 Japanese rice
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