3P1A


Conserved Protein Domain Family
PKc_Myt1

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cd14050: PKc_Myt1 
Click on image for an interactive view with Cn3D
Catalytic domain of the Dual-specificity protein kinase, Myt1
Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270952
Aligned: 12 rows
Threshold Bit Score: 397.835
Created: 10-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

cd14050 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd14050 is a member of the superfamily cl21453
cd14050 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #            # #                               #               #
3P1A_A        57 QSFQRLSRLGHGSYGEVFKVRSkedGRLYAVKRSMSPfrgpKDRARKLAEVGSHEKVgqHPCCVRLEQAWEEggILYLQT 136 human
Q9NI63       100 QCFERLAKLGEGSFGEVFQVRDrsdGQLYAVKISKQLfrgeQYRAERLEEVRRYEEFsgHENCIRFIRAWEQydRLYMQM 179 fruit fly
Q20085       104 HAFNFDKNLGKGSFGEVVAATCrstSKKFAIKKIPFS----KLSKDQYREAYGHMNIpcHPNIVRFHQAWIDkqILHIQL 179 nematode
Q91618       101 QCFKSICKLGRGSFGEVYKVQSledGCFYAVKRSVSPfrgeSDRQRKLQEVRKHERVgeHPNCLRFVRAWEEkrMLYLQT 180 African clawed ...
O18209       106 QVFQIDEIIGRGSFGEVFAARCredSQLYAVKVSLAPi--rQHSISKYREAESHMIIppHKNLVKFYRAWEEtgRLYIQT 183 nematode
BAB69973     100 QCFEVVQKLGEGSFGEVYKVKCkedDKFYAVKRSRERfkgeADRKRKLEEVHQHETLsrHPNCVEFLKAWAEkgHLYIQT 179 Asterina pectin...
XP_971257     79 QIYTKESVIGEGSFGVVFKVKSeqdDKFYAVKEFKSC----HALHYGYAEVENYEKIgeHDNCVKFIMAWEElkIVHIQM 154 red flour beetle
XP_002605794  64 QCFGIVDKLGEGSFGEVFKVRSkedGKLYAVKRSRERfrgeYDRKRKIGEAYRLEKLrrHPNCVQFYKAWEErqHLYIQT 143 Florida lancelet
XP_001621731  89 QCFEVISKLGAGSFGEVFKVKSkedGKFYAIKKSCDRfrgdVDRKNKLEEVNRHEQLkmHPNCVHFVKAWEErdHLYIQT 168 starlet sea ane...
XP_002131417 118 QCFTIEKRLGEGSFGEVMQVKSrdnSMRYAVKRSREKfrneSDRKRKLDEVKKHEQLpsHPNCVKFIKAWEEkhRLYIQT 197 Ciona intestinalis
AAI60663     106 QCFTNLGLIGRGSFGEVFKVVSltdNCQYAVKRSVHRfrseVERAKSITEAWNHEELhpHPYILGFIAAWEEagHLYIQT 185 zebrafish
Q99640       108 QSFQRLSRLGHGSYGEVFKVRSkedGRLYAVKRSMSPfrgpKDRARKLAEVGSHEKVgqHPCCVRLEQAWEEggILYLQT 187 human
Feature 1        ###  # #                                     # # ## #           #  #            
3P1A_A       137 ELCgPSLQQHCEAWgaSLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGp-rGRCKLGDFGLLVELGT------ 209 human
Q9NI63       180 ELCrESLEQYLLRCq-RIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGeddETCKLADFGLVIDVDR------ 252 fruit fly
Q20085       180 EMCdKSLAAYCHGId-WLEDKELWNVFLDILQGLGHLHNNFMLHNDIKPDNIFMTk-nKVCKLGDFGLISDMRSepi--- 254 nematode
Q91618       181 ELCaGSLQQHSEEFagSLPPRRVWNITCDLLHGLKHLHDRNLLHLDIKPANVFISf-sGVCKLGDFGLMVELDGt----- 254 African clawed ...
O18209       184 ELCdQSLLKYCTEKh-ALPEDEIWNIFVDLLQAVHHLHSNDMIHDDIKPENIFLTk-dMICKLGDFGLVINLKNp----- 256 nematode
BAB69973     180 ELCqMSLEEYSEGHh-DISESTVWSFLLDLMKGVKHLHDHDLLHLDIKPENIFVSm-yGACKLGDFGLTVQLGK------ 251 Asterina pectin...
XP_971257    155 EYCdLSLAQYAALTh-KIGESQLWEILYDMLKALDYLHRKNLIHLDVKPGNIMMSq--GFYKLADFGLLVDLNRhd---- 227 red flour beetle
XP_002605794 144 ELCqCSLEQYLEQQh-DIPEETVWNFLVDLLSGLKHLHDHRLIHLDIKPDNIFVSn-dGVCKIGDFGLVVEVDK------ 215 Florida lancelet
XP_001621731 169 ELCsSSLKDYLEKNd-SVSEREVWNFLLDLTLGLKHLHDSGMVHMDIKPANVFFGh-dGLCKIGDFGLVLELSK------ 240 starlet sea ane...
XP_002131417 198 ELCaTSLQRYLSKHs-HVPIYKIYKYLVDLLKGLHHIHSHGFIHFDVKPANIFLSl-dGTCKIGDFGLVVEQSK------ 269 Ciona intestinalis
AAI60663     186 ELCcTSLLLYAEETpcHTGEMRAWAYLCDMLSALIHLHDCGFAHLDIKPANFFITk-sGRLKLGDFGLLIKLPAnaqkqv 264 zebrafish
Q99640       188 ELCgPSLQQHCEAWgaSLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGp-rGRCKLGDFGLLVELGT------ 260 human
Feature 1                        ####                                                            
3P1A_A       210 --------AGAGEVQEGDPRYMAPELLQGsyGTAADVFSLGLTILEVAcNMELPHGGEGWQQLRQGYLPPEFtagLSSEL 281 human
Q9NI63       253 --------ANSHHATEGDSRYMAPEILQGhfSKAADIFSLGIAMLELAcYMDLPSNGPLWHELRHGILPEEFinkISLEL 324 fruit fly
Q20085       255 -----nnsSNKHYQSEGDGKYCSKEAINGtlSIFSDIFSFGISILEVGtNIHLPSYGTGWEPIRKWEIPEEIlepMSDEL 329 nematode
Q91618       255 --------EGSGEAQEGDPRYMAPELLDGifSKAADVFSLGMSLLEVAcNMELPKGGDGWQQLRQGHLPTEFtsdLPPDF 326 African clawed ...
O18209       257 --------NDVKSAEEGDSKYLAPEVLNGrpTKSSDIFSLGMTILEATtDLDVPSNGDSWHQIRNGQIPDRFfagISTDL 328 nematode
BAB69973     252 --------NDLTDAQEGDPRYLAPELLQGkfGKHADVFSIGITILELAcDLDLPQNGQLWHQLRNGDIPWDItkgISRSL 323 Asterina pectin...
XP_971257    228 -------gKKISTISDGDAKYLACEVLDGiyTYSCDIFGLGISLLELAtNIELPEFGPLWHQIRKQYLPAPFydgVTKSF 300 red flour beetle
XP_002605794 216 --------EDVCDAQEGDPKYIAPELLEGhfGPHADVFSLGVTILEAAcDLELPRNGVGWQQLRQGMIPAAFtagLSHEL 287 Florida lancelet
XP_001621731 241 --------VDTADALEGDPMYMAPELMQGsfTKAADIFSLGITLLEAAcDLDLPKGGDTWHQLRNGQLPHIFtqgLSPEL 312 starlet sea ane...
XP_002131417 270 --------EDILNATEGDNRYMALELLNGvfTNKADVFSLGIALLEITcNLELPVGGVSWQLLRQGYIPQECvnqLPFDL 341 Ciona intestinalis
AAI60663     265 neekremkKERDDLQEGDPRYMAPELLRGdyGTAADIFSLGISILELAcNIEVPKEGDDWQLLRNGHLPEEFtnvLSEEM 344 zebrafish
Q99640       261 --------AGAGEVQEGDPRYMAPELLQGsyGTAADVFSLGLTILEVAcNMELPHGGEGWQQLRQGYLPPEFtagLSSEL 332 human
Feature 1                                 
3P1A_A       282 RSVLVMMLEPDPKLRATaEALLALP 306 human
Q9NI63       325 QSVIKSMMKPDPAQRPTaEQLLSHP 349 fruit fly
Q20085       330 RELVKQMMDKAPTRRPTcSELMKNH 354 nematode
Q91618       327 LKVLSAMLEPDYRRRATvDWLLSLP 351 African clawed frog
O18209       329 RSLIALMLDSDPRIRPTsRDLLDHP 353 nematode
BAB69973     324 KDIITSMMDPDYQRRPSlEDLLHLP 348 Asterina pectinifera
XP_971257    301 AETIEKMMAKIHWQRPQaSKLLKST 325 red flour beetle
XP_002605794 288 RNIIQLMMHPDYVQRPSvADILARP 312 Florida lancelet
XP_001621731 313 IRLIAWMMHPIPESRPTvDDILALP 337 starlet sea anemone
XP_002131417 342 RTIIQWLMTPNYEERPSiVEVLNHP 366 Ciona intestinalis
AAI60663     345 LYILRLMLTPEPCNRATaQQLLSLP 369 zebrafish
Q99640       333 RSVLVMMLEPDPKLRATaEALLALP 357 human

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