Conserved Protein Domain Family
CPG4
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pfam15481: CPG4 
Chondroitin proteoglycan 4
CPG4 is a domain family found in nematodes of one of nine core chondroitin proteoglycans. Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. CPG4 has the largest predicted mass of the C. elegans CPGs at 84 kDa. The majority of its 35 predicted glycosaminoglycan attachment sites reside in the COOH-terminal half of the protein, of which four sites were confirmed by DTT modification. The family is rich in conserved cysteines.
Links
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Statistics
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PSSM-Id: 406043
Aligned: 9 rows
Threshold Bit Score: 91.3564
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A8X9H4       132 ECPRDCSNDLREALGIVLQDMSH--VERYHRICEKYSNASTCVNEdGRCdkDDRGMFEMMTSGLHYMCVEQELAFNATIK 209 Caenorhabditis ...
EGT50251      44 HCVRKCIDPFINSTISLWNMKNV--VNQAGKFCSQHAQAITCLEKeIFC--DHKKIFSKASSSVGYMCSTKQAVFHKMKD 119
EGT55771      52 YCMRKCIDPFINSTTSLWNMKNV--VNQARKVCSQHAQAITCLKKeQFC--DHLKIFSKASSSVEYMCATKHVLFERMES 127
1_pfamImport   1 NCAEGCLKPFLLTLRANFVSGNN--YERLVNTCEKLSEVYECMDRiKKC--QPNYLFRIFMDGFEYMCIEHPAAFRDLME 76 
2_pfamImport   1 -CLSECIQPLAKME---RSFAFI--FNNFEKVCDSLERGAHCV---MKCggEDAQKFHQLTSFYRLYCIDYEEDLEPHVS 71 
Q52GY3        25 ECLSKCLTPLAKLQ-----RSFSyvFNNFEKVCDLLEDGAFCA---RKCtqEDQTKFYQYTTFYRIHCIDYEEDIQEHLT 96  Caenorhabditis ...
3_pfamImport   1 -CLQKCMPTLSKFLDSLDTKHSLrdTKDTVALCRQLESIEECAAT-THC---DSTLLDLATKTYKFACVDKIESLGDSLK 75 
XP_002641989  39 SCFRKCMPAMDNVGIMLEIAKKP---EAMKAMCQNLTESSKCAMA-TGC---DATFVGALSNAFQFVCLDNLEKVTAQIT 111
Q17966        59 SCLRRCMPALDNIGALFDAAKNP---ETMKAMCRDMTEASKCATA-AGC---DKIFIGAISNAFQFVCMDNLEKVSSQIA 131 Caenorhabditis ...

A8X9H4       210 CIDDEAGLVQSECDAQCQT 228 Caenorhabditis briggsae
EGT50251     120 CLSPIVDDVISACDEKCYL 138
EGT55771     128 CLNPIVDDVMSTCDKECYS 146
1_pfamImport  77 CMDLHTQIVTKDCEQKCKA 95 
2_pfamImport  72 CLARASQGSDKECKRRCAM 90 
Q52GY3        97 CIAKAAEDADLVCKDKCKQ 115 Caenorhabditis elegans
3_pfamImport  76 CAQDAFSTARVDCETGCIV 94 
XP_002641989 112 CVQENAGDLQQECENECAV 130
Q17966       132 CIQENAGDLQQECESECAV 150 Caenorhabditis elegans
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