Conserved Protein Domain Family
PepN

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COG0308: PepN 
Aminopeptidase N, contains DUF3458 domain [Amino acid transport and metabolism]
Statistics
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PSSM-Id: 440077
Aligned: 690 rows
Threshold Bit Score: 142.089
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAM05018      17 NVDVLHMNLAFDVYDDRTSVKSLLRIrTRDgp----lEKLELNCRDLEVRAVSCi-----qSEVSyrYRk------dDAI 81  
WP_011555110  14 QPETETLDWRARVDFKTQRLHAEVTH-TLKea---saGPLDLDTRDLEIRDVIDaa----gRPLP--YIlspsepilGSR 83  
WP_010236266  54 VARVTHVALDLDLDFDAKMIGGGAVL-NILakd--daKQIVLDSNGLRIDRVTDgq----gNSLP--FTigeaeegkGAP 124 
WP_095989215  14 QPETERLTWKARVDFQSRQLHAEATL-TLKea---saGPLDLDTRELEVESVVDge----gRPLS--FLvspaepilGSR 83  
WP_046904503  49 VARVTHVDLDLALDFESRSVSGTATL-DVLadp--daDTIVLDSKGLQISAITNed----gADVP--FTvgetvegkGEP 119 
WP_052646562  71 QVSVRHIDIDWNVMLDSKTIEGSVIL-SIDkkdfltnQPLILDSRDLVIRKIEGssdkitfSPII--YKlgkrdpikGQA 147 
WP_047856473  14 QPETESLTWKARVDFRTRRLHAEATL-TLKea---saGPLDLDTRDLEIRSVVDaq----gKPLP--FLlsppepifGSR 83  
WP_013634544  44 HVKVKHLDLDLDVDFKQQIIKGIAVW-TIEnpn--kyDEIVFDTKGLNIQKIVLddk--tsEEPF--YAlgdeneifGQA 116 
WP_083987948  83 EARVTHVALDLALNFEAKDVFGTATL-DIMadd--daDTVVLDSDGLRISAITDeq----gNALP--YTvgehdeelGEP 153 
WP_013454766  46 EAVITHLKWTADINFENKTIQAIAQY-DISkap--naTKIILDTKNLHIEKVWLne----nEDTN--FElkekdeilGQA 116 
AAM05018      82 LEINfmdvIPPqtEIAIVTETVcRPTkNileGLYYDETPa---gAPPQQITQCQQWGFQRIVPCIDDMCAKCTYRTTIIA 158 
WP_011555110  84 LRIE----LPVg-LRQFTVRYRtAPHaS---ALQWLTPSqtaggKHPFLYSQCQAIHARSVVPLQDTPRIRIRYTASLRI 155 
WP_010236266 125 LTIQ----LNg--ARQLRIAYRsAPDaD---ALQWLTPEqtaggKYPYLFSQGQAILNRTWIPTQDSPGIRQTWEARITA 195 
WP_095989215  84 LRVE----LRPg-VKQLTVRYRtSPGaS---ALQWLTPAqtaggQAPYLFSQCQAIHARSVVPLQDTPRLRIRYEAELTV 155 
WP_046904503 120 VTVT----IGd--ARQITVAYt-APDsA---ALQWLSPEqtaggEHPYLLSQGQPTLNRTWIPTQDSPGIRQSWEARITA 189 
WP_052646562 148 IIIP----LQDs-TNYIRIKYStSPTaE---GLHWIKSEq---sEYSSLFTVACPIHARDFIPLQDTPQVRITYTAKIQS 216 
WP_047856473  84 LRVE----LSPg-TKQLTIRYRtSPQaS---ALQWLTPAqtaggQYPYLFSQCQAIHARSVVPLQDTPRIRIRYKAELTV 155 
WP_013634544 117 LSIQ----IAPe-TKKVSIYYYtNPGaE---ALQWVAPAqtfgrQSSFLYTQSQAILARTWIPCQDSPSIRFTYNAKVKV 188 
WP_083987948 154 ITVR----MGa--ARRITVTYRaAPDaA---ALQWLDPEqtaggEHPYLFSQGQAILNRTWIPTQDSPGIRQTWEARITA 224 
WP_013454766 117 LHIR----LSKe-TETISIQYKtPPSaE---ALQWLNAQqt-agASPFLFTQSQAILCRSWIPIQDSPGIRFTYEAKVKV 187 
AAM05018     159 DsRYTNLITNGDVAVERqTVK-Qg--RDKIVYDNSiTPMATYLFFLGVGTYATFKRefeypdgdtfM-LELLVPPG-SSe 233 
WP_011555110 156 P-KALKAVMAASFLRRE-EHGvE----AEEHYEMP-QPVPPYLLAFAVGSLAPKELg---------PrSRVWAEPElLEd 219 
WP_010236266 196 P-KPLDVVMSGV--RQG-EPEdLgngRRAFRFVMD-KPVPPYLIAIAAGDIDFRATg---------PrTGVWAEPAtLDr 261 
WP_095989215 156 P-RELRAVMAAGFVGRE-ERGeE----AVERYEMP-QPIPPYLLAFAVGRLASKELg---------PrSRVWAEPEvIEr 219 
WP_046904503 190 P-KPLTVVMSGL--SVG-EPEdVgddRRAFRFSMT-KPVAPYLIAIAAGDLEFRELg---------PrTGVWSEPAmIDa 255 
WP_052646562 217 K-PEFLVLMSASN-NPK-SKSsNg----YYEFEMN-NPIPPYLISLAIGDFKFKQLs---------NyIGIYANPSyIEr 279 
WP_047856473 156 P-KELKAVMAAGFVGRE-EQGvE----AVERYEMP-QPIPPYLLAFAVGRLAAKELg---------SrSRVWAEPEvLEe 219 
WP_013634544 189 P-KEFLALMSAE--NPQ-KRNsDg----IYTFQQK-HPIPSYLMALAVGDIRFKKIn---------EmSGVYAEPAmLDk 250 
WP_083987948 225 P-KPLTVVMSGL--SGS-EPVeVdgdRRAFTFSMD-KPVPPYLIALAAGDIAFRELg---------PrTGVWTEPVmLDr 290 
WP_013454766 188 P-QGNLALMSAE--NPQ-KIDsTg----NYSFKME-QPLPAYLMALAVGDLEYHKTg---------DeTGIYAESTtLDk 249 
AAM05018     234 eaAEKALDILHDSVMWVylftgPEQYdeaglpvrkelwelvrkredmklegkgarleelrefreklaglvagitpGyKYT 313 
WP_011555110 220 --AAEEFSGVDDMLRAA-----ESLF-------------------------------------------------G-PYD 242 
WP_010236266 262 --AYNEVADTEQLVEAA-----EELY-------------------------------------------------G-DYR 284 
WP_095989215 220 --AAAEFEDVDAMLRAA-----EALF-------------------------------------------------G-PYD 242 
WP_046904503 256 --AAAELEDTEAMVEAA-----EELY-------------------------------------------------G-PYR 278 
WP_052646562 280 --GITEFADLNKMMKVA-----ESLY-------------------------------------------------G-PYL 302 
WP_047856473 220 --AAEEFEDVDAMLRAA-----EELF-------------------------------------------------G-TYD 242 
WP_013634544 251 --AAHEFADVGKMLSAA-----ESLY-------------------------------------------------G-KYL 273 
WP_083987948 291 --AAAELADTEAMVAAA-----EKLY-------------------------------------------------G-DYR 313 
WP_013454766 250 --AIADLEDLQSFLETA-----EELY-------------------------------------------------G-KYR 272 
AAM05018     314 GTVYREIGM-QNSDFGGMENVGNTTITTNrIMPFpqitdsafEYMIRVKVHEYYHNQNGSEVTGKSPFEIWLNEAVTVHV 392 
WP_011555110 243 WERFDLLTMpPSFPYGGMENPRLTFLTPT-LITGd-------KSLVNVVAHELAHSWTGNLVTNASAEHFWLNEGFTVFA 314 
WP_010236266 285 WGRYDMIVLpPSFPYGGMENPVMTFLTPT-FIAGd-------RSNNGLVAHELAHSWSGNLVTNAVWGDGWLNEGVTSYF 356 
WP_095989215 243 WERFDLLTMpPSFPYGGMENPRLTFLTPT-LLAGd-------KSLVSVVAHELAHSWTGNLVTNASAEHFWLNEGFTVFA 314 
WP_046904503 279 WGRYDMIVLpPSFPYGGMENPVMTFLTPT-FIAGd-------KSLTGLVAHELAHSWSGNLVTNANWSDSWLNEGITSYF 350 
WP_052646562 303 WSRYDLLILpNTFPAGAMENPSLTFVSPT-IITGd-------KSFVSVIAHELAHSWSGNLVTNATWNDIWLNEGITTYM 374 
WP_047856473 243 WERFDLLTMpPSFPYGGMENPRLTFLTPS-LLAGd-------KSLVSVVAHELAHSWTGNLVTNATAEHFWLNEGFTVFA 314 
WP_013634544 274 WGRYDILVLpPSFPFGGMENPNLTFATPT-VIAGd-------RSLANLVAHELAHSWSGNLATNATWNDFWLNEGFTMYF 345 
WP_083987948 314 WGRYDMIVLpPAFPYGGMENPVMTFLTPT-FIAGd-------RSLTGLVAHELAHSWSGNLVTNSNWRDSWLNEGVTSYF 385 
WP_013454766 273 WEQFDVLVLpPSFPFGGMENPRLTFATPT-ILSGd-------KSLVSLIAHELAHSWSGNLVTNATWDDFWLNEGFTVYF 344 
AAM05018     393 EEQYHAFLFGED-YQRlGrVLDLLapaSGT-----FALDSGAASMPIIp-DGFNDPNDLITAVTYVKAPEYVRMVETLIG 465 
WP_011555110 315 ERRILEVLEGPEvSALhG-ALGRR---ALDsalqhF--RAHPQLTSLRthLAGVDPDEAFSQIPYEKGYLLLRAMEDAAG 388 
WP_010236266 357 ENRIVEKVYGKSrAEQeA-ALSYA---NIIetldeV--GSDAPGTALHneGD---GELIGSAIAYDKGHFFLRTVERAVG 427 
WP_095989215 315 ERRIVEALYGKDvAALhA-TLGRG---SLEetiqhF--KEHPQLTCLRthLTGVDPDEAFSLVPYEKGYLFLRALEDAVG 388 
WP_046904503 351 ENRIVEKVYGKKrAEQeA-ALSFA---GMEeaiaeN--GSDAMITALHlpPEEATPDGGSSGIIYDKGATFMRTVEKIVE 424 
WP_052646562 375 QNRIVEEVYGKKqAEIeV-RLSYE---QLLkaykiL----APEDLILNqkFRNPNPDDVFTPVPYNKGFLFIKHLEQLFG 446 
WP_047856473 315 ERRIIEALYGEEvAKLhA-ALGRR---VLEdamqhF--KAHPQLTALRthLTGVDPDEAFSQIPYEKGYLLLRALEEAVG 388 
WP_013634544 346 ERRIIEKLYGKDeADMqE-VLGYK---DLEngikdF--GKTHPDTRLNldLTDRSPDDAVTDIAYEKGFLFLKNIELVVG 419 
WP_083987948 386 EGRITEEIYGEQrARQeE-ALSFA---TVEnvlaeA--GANDPGTALHqpDD---VESAGSEIVYDKGAAFLRTVEQIAG 456 
WP_013454766 345 EYRIMEALYSKDySEMlA-SISLK---ELKeesqeLIDNENAEDTHLKldLKGRNPDVGMAAIAYDKGYFFLRKIEELTG 420 
AAM05018     466 RETFVRGLDRYFKKFSHSNATTDDWIEAMEE-----ESGQaLKEMSETWLKQIKFPVVEVSAeydrdeRkfaFLIKQKvP 540 
WP_011555110 389 RPAFDEFLRRYLATYRFRALTTEEFVAFAEKe----lPGVlTKVDAEAYLHRPGVPPGAPSPrs---lR---LEAMDAlR 458 
WP_010236266 428 RERFDAWLRQWFDNHAFQPATSQMIYDDMLAnlvtsPAEa-KQLKLREWIFEPGLPsnvakpdpaafatvdaavtayadn 506 
WP_095989215 389 RDAFDGFLRDYLQAHRFQALTTEEFTTFVERr----lPGAlAKVDAEAYLSKPGIPPGAPTAhs---eR---LAALARfT 458 
WP_046904503 425 REKFDAWLRQWFDSHAFQPATSALLLEDMRAnlvqgDKELeEKLQLDAWVYEPGLPdnvarpaesafaevdraasayedd 504 
WP_052646562 447 RSEIDNFLREYTREFAFKAISTNDFEQYLRKhllnkNSRLsQRASIKEWLYGTDLPTTFIEPsk---rH---LIAIGNqA 520 
WP_047856473 389 RPAFDAFLKRYLEAHRFQALTTEQFTAFVEKh----lPGAlAKVDAEAYLNKPGIPGSAPVPrs---eR---LERMASyK 458 
WP_013634544 420 REKFDHFLKQYFAKYAFKSVTLKDFEDELNNnvikdDENLkTAINAYGWIYQPGIPKNAKLPhs---aR---FDAIDAlR 493 
WP_083987948 457 RERFDAWLRQWFDNHAFQPATSQMILADMQAnlvagDEELgRRLMLREWIFEPGLPanvkrpdpqafagvdgaaaryaat 536 
WP_013454766 421 RENFDTFLKQYFNEHAFQSINTEQFLLYMEQnlfakKGIElPKDLFSNWIYSAGIPDDLPKPns---eR---FRNVEQsi 494 
AAM05018     541 AggkpwefpfkaalvdEngndlAe--vLeriSEeTS-TvtienvdlpaflslnrgysfYGKLvykasqeelllqvrkdsd 617 
WP_011555110 459 G---------------Kvp------tpE---QA-KDwTpa----------------ewQLYLeslp-----------wdi 486 
WP_010236266 507 gtiptgwsgwtaaeqmrfldnipkertaaqlaalndalglsetgnnevlflwlelalanryqpavpqaevflseigrakf 586 
WP_095989215 459 G---------------Qvp------stE---DV-KDwTpa----------------ewHLYIdrlp-----------art 486 
WP_046904503 505 gtlnpelwggwttaerqrflarlprelsaaklaeldsklglsetgnneirfawlelalenryepavpqaeqflstvgrtk 584 
WP_052646562 521 K---------------Ewaad--eitqI---DT-AGwRgq----------------qwIYFIdnlp-----------tkl 552 
WP_047856473 459 A---------------Kvp------tkD---EV-KDwTpa----------------ewQLYLqslp-----------hgt 486 
WP_013634544 494 S---------------Gsi-qgQpadkL---SR-NInStn----------------ekLYFIqslp-----------dti 526 
WP_083987948 537 rqpdaaawqgwnsaerlrflsklpdemsaaqlaaldsafglsgsgnnevlfawlrtalsnryepavpvaeaflarvgrmk 616 
WP_013454766 495 anwlntesidtlktqdwstheflhffhqlpdsigysevravdekfnftnsgnaevltewfllaikkdylpaykamenfli 574 
AAM05018     618 ITGRFTAFYTLVdrekfrllKNPDak-psEEFVDLYYRllndrqlleraggqfltifesvedeefahsyqalydvkqkil 696 
WP_011555110 487 PRDVIQQLDARFsl-----tESRNsevlvAWLVVALRAdwe--------------------------------------- 522 
WP_010236266 587 vrplfavlwdqgdwgrpiakriyaetrdgyhavtragvdrlmaad----------------------------------- 631 
WP_095989215 487 PHKTLRELDERFhl-----tRSGNaevlvAWLTVALRSgwe--------------------------------------- 522 
WP_046904503 585 fvrplfkalvdqgawgrpiaeriyadtrsgyhavtqgavdkvmgrdg--------------------------------- 631 
WP_052646562 553 SPNKLEELNKILni-----kNSRNaliisKWLTLAIANnye--------------------------------------- 588 
WP_047856473 487 SKDVFRQLDDRFql-----tKSQNaevlvSWLVASLRAgwa--------------------------------------- 522 
WP_013634544 527 SLKQMQYIDSVFhf-----tTSHNseiqyAWYLLSIKKdyq--------------------------------------- 562 
WP_083987948 617 fvaplfgvlmgegewgqpiarriyaatypsyhavtrgavdramkagd--------------------------------- 663 
WP_013454766 575 ntgrkkflmpiygeliktetgksialniykkarenyhyvsyisldkllnyetd--------------------------- 627 
AAM05018     697 kaiawkyrssiiSAYRFFedssvsrdstleeaarvikvrqakniclniletldtpeihslIKQqfetatcatdrlnafAA 776 
WP_011555110 523 ---------pavARTETFlgevg---------------------------------rmkyLKPl-------------yGV 547 
WP_010236266     --------------------------------------------------------------------------------     
WP_095989215 523 ---------pawERAAAFlgevg---------------------------------rmkyLKPl-------------yGA 547 
WP_046904503     --------------------------------------------------------------------------------     
WP_052646562 589 ---------payGSLERYltiig---------------------------------kmslIKPi-------------yEE 613 
WP_047856473 523 ---------palGRTEAFlgevg---------------------------------rmkyLKPl-------------yGA 547 
WP_013634544 563 ---------pvySYLDTFlntvg---------------------------------rrkfIEPl-------------ySE 587 
WP_083987948     --------------------------------------------------------------------------------     
WP_013454766     --------------------------------------------------------------------------------     
AAM05018     777 YLNSSAPdkievlrafeaeskqnliaWE 804 
WP_011555110 548 LSASHAHrsla------------ralFK 563 
WP_010236266     ----------------------------     
WP_095989215 548 LVTSPEGkvra------------rrlFQ 563 
WP_046904503     ----------------------------     
WP_052646562 614 LVKTNEGlkia------------nhiYN 629 
WP_047856473 548 LAATSEGkala------------rsvFN 563 
WP_013634544 588 LLTTEKGkkma------------kdfYE 603 
WP_083987948     ----------------------------     
WP_013454766     ----------------------------     
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