Conserved Protein Domain Family
AKR_DrGR-like
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cd19136: AKR_DrGR-like 
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins
Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Links
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Statistics
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PSSM-Id: 381362
Aligned: 26 rows
Threshold Bit Score: 357.327
Created: 9-Mar-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ###                        #   ##                                         
NP_001006056  16 MPLLGLGTFRLqgqeDTYSAVDAALKA-GYRAFDTAAVYr---NEAHLGHALRcllpk-------------------hgl 72  zebrafish
EED93779      12 MPWVGYGTYRLgq-rHARTATFQALNV-GYRQIDTAFIYggqtTEIEVGKAIQdaleh------------------niis 71  Thalassiosira p...
EEC04562      17 LPIVGFGTYRIrd-kDLSQLLRPVVQS-GYRLIDTAPLYk---NEPVLAAFLRdlpq--------------------ygl 71  black-legged tick
EKX40244       8 LPPLFFGTFQLrg-eEASRATQQAMEL-GYRAIDTASIYr---NEEDIAMGLAasg-----------------------v 59  Guillardia thet...
PRW60380      15 MPAVGLGTFRVrg-qEAVDAVSWALAA-GYRHIDTASIYk---NEEEIGTAIRasg-----------------------i 66  Chlorella sorok...
OUS46675      62 MPMLAFGTYRLrg-eTCRDAVRDALRC-GFQHVDTASVYg---NERDVGEALRach----------------------re 114 Ostreococcus tauri
PNR52804      22 IPRLGLGTFRArd-dNVRKAVLCALQC-GYTHIDTASIYk---NEVEIGEAVRssg-----------------------i 73  Physcomitrella ...
PNW85976      28 LPTVGLGTFKAgg-dEARGAVLAALKA-GIRHIDTASIYk---NEAPIREALAasg-----------------------l 79  Chlamydomonas r...
PNF38295       8 IYFTSVGTYRIhgqsVIHRVIEAGLKA-GYRAFDTAAVYr---NEEAIGLALKtllpk-------------------fsl 64  Cryptotermes se...
EPR64571     240 FPILGLGTYRLhg-eECMAVVERAVSLrQFMLIDTASVYr---NEEEVGKALRdagargfpwqlylrddcemnircrrea 315 Toxoplasma gond...

Feature 1                 #                                  ##                                  
NP_001006056  73 sREDVFITSKLGPkd---qgSKARNGCQKSLEQLglGYIDLYLIHWPGtqglpvgdkrnpeNRAQSWRVLEEFYSEGKFR 149 zebrafish
EED93779      72 sREELFITTKQWReyh--gyEKSMECLNLSLDRLgvDYVDCWMMHWPGp-----------sLRAETWRAMEDAYRQGKAR 138 Thalassiosira p...
EEC04562      72 qRKDIFVASKVPPidh--gsAKSRSSALGILERLniDKLDLLLLHWPGvqgmkpsdpkqaeLRKESWLEMERLYKEGKLS 149 black-legged tick
EKX40244      60 rREDVFITSKLAPneq--gySKAMSALTSSLQRLntSYLDLYLIHWPGaaktplespankrLRLESWQALEDALKLGMIR 137 Guillardia thet...
PRW60380      67 pREQLFITSKVSPyqq--gtEAATAACEASLRLLg-THIDLMLVHWPGvakvdaaspdnaaMRRQTWRVLEQLHRRGQLR 143 Chlorella sorok...
OUS46675     115 vSERIFVTTKIAPsem-rseEEAAAAIAGVNERLg-RTPDLVLVHWPGrdkespdserhrdARRWTWRALENALKMGQCR 192 Ostreococcus tauri
PNR52804      74 eRASLFITSKVSPfeq--gfEKATQAVNNILDRLglSYLDLCLIHWPGaakldtksiqnskLRSETWRALEQFYKQGKCR 151 Physcomitrella ...
PNW85976      80 pRGSVFLTSKVSPyeq--gaGRARQAVEGILERLgtDYVDLVLVHWPGvartppdsaanaqQRAATWSELQQLYREGRVR 157 Chlamydomonas r...
PNF38295      65 sREDIFLTTKLGDhg----vGTTTKAVKSSLKKLgtSYVDLYLVHWPGvsrlpvyspdnaiIRSDTWRELVTLHRQGLLR 140 Cryptotermes se...
EPR64571     316 sNLGVFLTSKISPkdvaggrERAYEAALMSMKRLgvEQLDLYLIHWPGvrghksssrenrrLRHECWQALEQLYKEKKVR 395 Toxoplasma gond...

Feature 1            ##                      #                         #######           #       
NP_001006056 150 AIGVSNYtvEHMQELLKsc--kvPPAVLQVEFHPKllQNDLRGLCKIRgVCFQAYSSLGTGll----lSNPVVLEIAKEC 223 zebrafish
EED93779     139 SIAVSNFtiQHLELLKKsak-lwPPAVNQVECHPYypQNELLEYCKREgIVVQAYASLGVLggk--liESEPVLAASKHL 215 Thalassiosira p...
EEC04562     150 AIGVSNYtvRHLQELLSyc--tvRPTVNQVEFHPHlvQEDLLRYCKDHqIVLQAYSSLGAAngvsailGEPVIVDIANKC 227 black-legged tick
EKX40244     138 RAGVSNFcvRHLQELLAcs--elVPCVNQVELHPAcfQEELLRFCEAHkVQVQAYSPLGSPagvqsllSNADVLRASKEE 215 Guillardia thet...
PRW60380     144 VIGVSNYeiKHLEELLGya--evKPAVNQVECHPRyqQRDLRAFCQAHgIAVVAYSSFGSSql----lSDPAVQAVVAAE 217 Chlorella sorok...
OUS46675     193 AIGVSNYelSHLRELLQfc--dvKPAVNQIELHARfpQTELRAFCESVgVHVVGYSPLGVGal----lDDDRVKAYAATI 266 Ostreococcus tauri
PNR52804     152 AIGVSNYteKHLNELISss--eiKPMVNQVEVHPWltQTQLRNFCNLHgIVVQAYSPLGVGsl----lKDSTVQGVASKC 225 Physcomitrella ...
PNW85976     158 SLGVSNYeeRHVAELMAdpaaevKPMVNQFEVHPRrpRRELRQLCKQEgIAVVAYASLGCGdl----lTAPPVRRAAAAV 233 Chlamydomonas r...
PNF38295     141 AIGISNYtvQHLKELIEnsh-gvIPAVNQVEYHPHykQPELLKFCQDRgILLQAYCSLGGSsdr-rllEDATVGAVAKKL 218 Cryptotermes se...
EPR64571     396 AIGVSNFlvRHLEDLLEdgv-evVPMVNQIEFQPLcfDRDLLKWGEKHgMRIQAYASLGSGdpr--llRNPTVLAIAVEC 472 Toxoplasma gond...

Feature 1                 #              #### #  #  ##                        
NP_001006056 224 GRt-----PAQVLLRWAVQqSIAVLPKSsQPERVKENGRl-----fDFEISEEDMERLSAL 274 zebrafish
EED93779     216 SNsqrtvsAAQVLLRWALQrNCAIVPKTsSPARMKENANv-----fGFVLTDEEMIDISKL 271 Thalassiosira pseudonana CCMP1335
EEC04562     228 QKt-----PAQVVLRWALQlGIAVIPKStKAERIEENSKl-----fDFSLSEDQIASISGL 278 black-legged tick
EKX40244     216 GVs-----AAQVLIRWAMQtCGSAVARSsNEQRLAENLEtt----qVFEHDESTDTQGNRL 267 Guillardia theta CCMP2712
PRW60380     218 GIt-----PAQALLLWGLQrGCGVLPKSvRRERIEEAAParl--agLGELSPEALAALDAL 271 Chlorella sorokiniana
OUS46675     267 GLr-----PAPALVRWTLSmGASVVVKSsVAERTEENFTaisdlddDFVHEAAEKLETAFA 322 Ostreococcus tauri
PNR52804     226 KRs-----PAQVLLRWGIQnDMVVLPKSvHQEYIVENGDi-----fGFSLSVEDMASLNSL 276 Physcomitrella patens
PNW85976     234 ARs-----PAQVLLRWALQeGCAVIPKSvRPERLAEWTEpql-lgaDWGLSGEQMAALAAM 288 Chlamydomonas reinhardtii
PNF38295     219 DRs-----PAQVLLCWALQqGIGVIPKSvSPDHISDNIKl------DFIISESDMVTLNSI 268 Cryptotermes secundus
EPR64571     473 GVt-----PALVLLRWALQhGCHVIPCSrRETHLIEDSHv-----fDFCLNDEQMTLLDRL 523 Toxoplasma gondii GT1

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