1B4F,3BS5,2DL0


Conserved Protein Domain Family
SAM
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smart00454: SAM 
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Sterile alpha motif.
Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.
Links
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Statistics
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PSSM-Id: 197735
Aligned: 99 rows
Threshold Bit Score: 33.8086
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1B4F_A      6 PDYTSFNTVDEWLEAIKMGQ-YKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQ 73   human
O76699    186 EHKPGMRDLGYWLKKLRLHK-YAPLFQDMTY--RQLLSLN-DNVLERMKV-TNGARKKIAQSIEKLYER 249  Caenorhabditis elegans
O94033    611 SSLELLNNIPAWLKLLRLHK-YTECLKDVPW--KELIELD-NDQLESKGVAALGARRKLLKAFDVVKNN 675  Candida albicans
Q23972    593 TRNVGMSGIGLWLKSLRLHK-YIELFKNMTY--EEMLLIT-EDFLQSVGVTKGASH-KLALCIDKLKER 656  fruit fly
Q08831    448 TDPKLLKNIPMWLKSLRLHK-YSDALSGTPW--IELIYLD-DETLEKKGVLALGARRKLLKAFGIVIDY 512  Saccharomyces cerevisiae S288c
Q13094     12 VLGWDPDSLADYFKKLNYKD-CEKAVKKYHIDGARFLNLT-ENDIQKFPKLRVPILSKLSQEINKNEER 78   human
Q21982    142 TSHWVETVLGRVANDKKFLDrVNAAVFRNRITGARLLGMT-QNDLEHLGVHKVGSRIELMKMIRKLADT 209  Caenorhabditis elegans
EAW96562  485 FAKWTKEQVCNWLMEQGLGS-YLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALgse 552  human
NP_510311 611 FVDWRSEQLADWIAEIGYPQ-YMNEVSRHVRSGRHFLNMSMNEYEGVLNIKNPVHRKRVAILLRRIEED 678  nematode
NP_498323 367 VKEWSLDDVLLWLQSAQMDD-VAGLLIGYDLRGEDLLQWN-DQTLAQLGVSNPEIRKKLLDDLSKIIEN 433  nematode
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