2DLY,2SHP,1RJA,2IUG,2KK6,2YSX,2EKX,1MW4,2AUG,2VIF,1I3Z,1KA6,1RQQ


Conserved Protein Domain Family
SH2

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smart00252: SH2 
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Src homology 2 domains
Src homology 2 domains bind phosphotyrosine-containing polypeptides via 2 surface pockets. Specificity is provided via interaction with residues that are distinct from the phosphotyrosine. Only a single occurrence of a SH2 domain has been found in S. cerevisiae.
Statistics
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PSSM-Id: 214585
Aligned: 167 rows
Threshold Bit Score: 48.3791
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DLY_A        16 EPWFFGAI----KRADAEKQLLysENqtGAFLIRESES-QKGDFSLSVLDE-----------GVVKHYRIRRLDe----- 74  house mouse
Q15464       408 QIWYHGAI----SRGDAENLLR--LckeCSYLVRNSQT-SKHDYSLSLRSN-----------QGFMHMKLAKTK------ 463 human
O88834       223 QPWFHGPL----SRAEAENLLS--LckeGSYLVRLSET-RAQDCILSLRSN-----------QGSMHLKFARTRe----- 279 house mouse
Q18462        82 QDWFWGMI----TQTEAEGHLK--DcrhGEFLVRS--M-LFQDNPIVVIDVvv-------vsDKSRTFQQFQASpv---- 141 Caenorhabditis ...
Q21299        70 RNWYHGMM----FGKAAEKLLK--WE--SSYIVRRSMGpTHKFLCITARVE-----------DKYFHFQFNWNS------ 124 Caenorhabditis ...
NP_001154915  65 paWFHGFI----TRREAERLLE--PKpqGCYLVRFSES--AVTFVLTYRSR-----------TCCRHFLLAQLRd----- 120 human
DAA18426     587 PHWNDGAIlgfvNKQLAHDLLI--NkpdGTFLMRFSDS-EIGGITIAWKFDspdrnlwnlkpFTTRDFSIRSLAdrlgdl 663 cattle
XP_003355535 451 drliiGFI----SKQYVTSLLL--NepdGTFLLRFSDS-EIGGITIAHVIRgqd------gsPQIENIQPFSAKd----- 512 pig
XP_311525    547 dntiiGFI----HKSTAEKYLA--KcvpGTFLLRFTDS-VLGGISIAWVHEsnd------gqRQVLHIQPFTAKd----- 608 Anopheles gambi...
CAA22261      76 LHVYHGVL----FGSEAEKLLT--Wd--RAYLVRRAITkPNKFLCISVNWK-----------NKIFHYQLDFNE------ 130 nematode
2DLY_A        75 --GG-FFLTR---------RKVFSTLNEFVNYYTTTSDG 101 house mouse
Q15464       464 --EK-YVLGQn--------SPPFDSVPEVIHYYTTRKLP 491 human
O88834       280 --NQ-VVLGQh--------SGPFPSIPELVLHYSARPLP 307 house mouse
Q18462       142 -vSK-WQLDSy--------PSRHKTLVDLVAYYNRHFIG 170 Caenorhabditis elegans
Q21299       125 --EG-WSCPI----------LYEKFPRIPVKRYEHIYQL 150 Caenorhabditis elegans
NP_001154915 121 --GRhVVLGE---------DSAHARLQDLLLHYTAHPLS 148 human
DAA18426     664 nyLI-YVFPD-------------RPKDEVFSKYYTPVLA 688 cattle
XP_003355535 513 -lSI-RSLGD-----------RIRDLAQLKNLYPKKPKD 538 pig
XP_311525    609 -lVV-RSLAN-----------RICDLGELTYLYPTIPKQ 634 Anopheles gambiae str. PEST
CAA22261     131 --DG-WCCKKlyekfptmpNRRFLHIRQLLEAWSQATPF 166 nematode
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