Conserved Protein Domain Family
UNC-93

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pfam05978: UNC-93 
Ion channel regulatory protein UNC-93
This family of proteins is a component of a multi-subunit protein complex which is involved in the coordination of muscle contraction. UNC-93 is most likely an ion channel regulatory protein.
Statistics
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PSSM-Id: 461792
Aligned: 9 rows
Threshold Bit Score: 418.649
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O61865        56 DPAR-INSHAGYYGQATCYLAFVFTCLVSPTFLYATSAKTTLIIAAACFTSFPLGFLYTNQYYYFFSAALNGVGFALYYT 134 Caenorhabditis ...
Q18251        40 SPDTgITANSGYYSLSIIYFFFTFFNIVIPSIVQKLGAKWSQIIGASGYLFFMLTFLYLNVWLLYFGSAVLGAGAALLWA 119 Caenorhabditis ...
Q9XWR7        66 SPDT-ISAYAGYYGAAFHLSAFAVFSLITPSLQHFVPSKWFLTLASALFAVYYLGFFQLNKYYFYLTQALMGVGYSFYNN 144 Caenorhabditis ...
2_pfamImport   1 TPEK-VSPYAGYYGQAVTFASFMTACLFAPSILNLTTPKFLLVFAGISYALFPMGFLFFNTYFYYFSGALIGAGTAAFYL 79 
Q8BJ51        43 DFHG-----SGYTSLAIIYGVFSASNLITPSVVAIVGPQISMFVSGLFYSMYIAVFIQPFPWSFYTASVFIGIAAAVLWT 117 house mouse
Q21545        41 dsGS-INKHAGYYSLAIIYAVFTVANFAAAPIVDILTPKWAMVFGSCCYTIFQVGFLFLNEWYLYASSALLGFGASIIWT 119 Caenorhabditis ...
Q9XV34        38 ldGS-ITKYAGYYSLAIIYAFYTLGNLTAAQIVDTLTPKWAMCIGALCYASFQVGFLFLNSTYLYISSAILGFGSSILWT 116 Caenorhabditis ...
Q19932        42 rGGN-IDPHAGYHSFAILYFFFTIACLLIAPVVDLITAKWSMVVGFFTYIAFQLGFLELNSAYLYTTSALLGIGAAFLWV 120 Caenorhabditis ...
1_pfamImport   1 GRGG-IEHRDGYLALCLIYFFNTISCFFAPYVVSKLSGKWAMVAGMMTIIIVHSSYFLPNRYFILIASSIGGFGATFIWV 79 
O61865       135 GNGGYLTSHSTRKTIESNVSISWAIGSSCMIVGaGI----IALITFLTAGqgsevamdlanatvtqhferrfSDTEIYLL 210 Caenorhabditis ...
Q18251       120 GNGCYLVEISRRNKMERNSGIMWAMLQSSLITG-GI----FLIYVLRSGD----------------------LSNSFTFI 172 Caenorhabditis ...
Q9XWR7       145 GEGQYLSEHSSRRTIESNTGIETAVGHASMFFG-GIalivLCFLLHTDGGtgi-----------------eySDLQIRFI 206 Caenorhabditis ...
2_pfamImport  80 GMGSYLSAHSTRETIETNVSFSWSVSCFCLMIGaGI----LATITSLSTPptvpqtanstw-qeevrherrySDFEIKLL 154
Q8BJ51       118 AQGNCLTINSDEHTIGRNSGIFWALLQSSLFFG-NL----YIYFAWQGKTq--------------------iSEHDRRTV 172 house mouse
Q21545       120 GQGSYLSQNCTKETTSRNSSMLWAMSESSLLGG-GI----FLFIVFTVQGaqd-----------------qiPSSTINIL 177 Caenorhabditis ...
Q9XV34       117 GQGSYLSQNCTKETTSRMAALLWGMHECCLIGG-GI----LIFIVFSVTDsyd-----------------viPKFTIKLL 174 Caenorhabditis ...
Q19932       121 GQGKYLTENCTSETIERNTALMWLIFKFSLLGG-GV----FLYFMFQDQTmhe-----------------lvLSGDFKIF 178 Caenorhabditis ...
1_pfamImport  80 GQGQYIIENVSDENREKNTSIQWALYKMSLIIG-GI----FFFFYFQNEPiea-----------------iaKNGQMEKF 137
O61865       211 FSVFAAISFVGCITFALLPSNDIgNCIESSKKI--------------------VAFRDGIALMYRAFRSPKMIVLIPTFV 270 Caenorhabditis ...
Q18251       173 YMVFSSVIAIGIVVLLFLPNNPA-QYGSQNEDIessedplilpetendvtlpaSSVSEQLRSTIALLLTPNMLCLAVLFV 251 Caenorhabditis ...
Q9XWR7       207 YGTMFILNIFSVIVFAFLPTKQYdSIASKSSTVv-------------------PSFANQIKQLLKAFQSTNLLILMPFFF 267 Caenorhabditis ...
2_pfamImport 155 SAAFCGMASLGIVIFSFLPSKSVeNSLESGEKP--------------------QKFGESFKLTCRTVISPKMMQILPLTI 214
Q8BJ51       173 FIALTVISLVGTVLFFLIRKPDPeNVLGEEESCddqdmeat-----esaqnnvTKAVDAFKKSLRLCVTREMLLLSVTTA 247 house mouse
Q21545       178 YSVFTVLSLISTVIFALLRAPSYpAVVDRKN------------------------YGKLVASTFKLMLTKKMILLAFVFA 233 Caenorhabditis ...
Q9XV34       175 YSMFTILAILSAFVFSMLREPVY-----KKEKS--------------------GCYKKLMTSTFRLLFTRKMLFLIVIFS 229 Caenorhabditis ...
Q19932       179 VYVFCSISVVAAVNTAFLPAPAY---VPEKREA--------------------VTLAGTLKVTFRLIRQTPMLLLAFIFL 235 Caenorhabditis ...
1_pfamImport 138 FMVFLACIVISIINTCFLPQSEM----SRNRVS--------------------QPFFQTTKNCFKLLKTQRMISLAVFFF 193
O61865       271 LTGVHTSFWVSIYPTTLTFNSHLSAMI-YLPAIYSFGVGLGETTMGLLISFCSKRIKNFGMRpTMFIGCFLTCLYCALVV 349 Caenorhabditis ...
Q18251       252 YSGLEMTFYTGVYTSCLSATLPLKIFSdLVIPYNALSIGAGQIAGGVVTGPLMKILRMRSQH-IIYLAFVGHLTSFILAY 330 Caenorhabditis ...
Q9XWR7       268 FQGFAVSFLMTVYPTTLSFTHAFKTDI-YIIGIYSVSMGLAEAIGGIFLRPLLKRAGDYGLYvTAGFNFLSYSVVIILAF 346 Caenorhabditis ...
2_pfamImport 215 LGGFNVSFWLSIFPTAMNFT-KLNAHLtYIPAIYSLGAGLGEVLMGIVISMMSKRIKGFGLKpTMVLGALAVCIYCCLVH 293
Q8BJ51       248 YTGLELTFFSGVYGTCIGAVNKFGTEEkSLIGLSGIFIGIGEILGGSLFGLLSKNSR-FGRNpVVLLGTLVHFVAFYLIF 326 house mouse
Q21545       234 YTGIEQSFWTAIYPTCISFTKQLGNNTnALLALNAICTGFGQIAAGVFFGLLGDKSRKIGRDaIILCGTIVHLVVYALCY 313 Caenorhabditis ...
Q9XV34       230 YVGIEQSFWTGIYPTCVSFTRKLGYNGnALVALNLICTGIGQVSAGIIFGFLGDKVRKLGRDyLILFATFIHLLAYVIIG 309 Caenorhabditis ...
Q19932       236 YTGFSRSFWIAIYPTCIKFTSKLGENTtKLLAISGIATGIGQIVAGGIFSVLGKRVRILGKDmIVVIACVLHLICFVLIY 315 Caenorhabditis ...
1_pfamImport 194 YTGLVRSFWISIYPFCIKFTSNLASNTtRILTIGMIVTGCGQVIGSIFVAIIGNKIRKFGQHvLILGALILHVILFLMIS 273
O61865       350 ISTPPTAPMAPTSEKPLLf--QPTRYLVFIIALIGGMSDCCLCSVRSVVCAIAMPTRRNQAFSVSKFYQAIGCCVIFFIS 427 Caenorhabditis ...
Q18251       331 LCLPYDSTVHSTDASTYL---APTLNLTLIISFLLGVSDAFWQTQIYVTIGQVFKEDPVNAFAIFKFFQSMAACVSFFYS 407 Caenorhabditis ...
Q9XWR7       347 LSIPNLSTFGPTSSPPIFl--TPSRLLVFIIGFLIGFSDFCVTMARAVICQVAVPDCRMQVFSLSKLYQSGSSVVVLLLT 424 Caenorhabditis ...
2_pfamImport 294 ASTPFEAPMRPTSQPSLLi--SHSYPLIFIISFFCGMSDCCINSVRSVICALVMPSRRSQSFAVARMYHAFACTICFFFS 371
Q8BJ51       327 LNMPGDAPIAPVEGTNSIayiRPSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAPAFAVFKFVQSICAAVAFFYS 406 house mouse
Q21545       314 INFPQDSSLKKTDEMGGLi--QPNLAIALIAGGLLGFGDAIWNTQIYSFLCDTFSKQSAQAFSLFKLYQSALSCAAFFYA 391 Caenorhabditis ...
Q9XV34       310 LNFPASASLTKNDDSGLFw--TPNLYVALAIGIVLGFADACWNTQIMSFLCETYPEKSAQAFAIFKFFESLLSCFTFIFS 387 Caenorhabditis ...
Q19932       316 LFFPYDAPLRPTQNVGIF---EPNAYIAIFCSGLLGFGDAIIQTQVYSFLCDGYSEESSHAFALFKFYSAISSTIAFFVS 392 Caenorhabditis ...
1_pfamImport 274 LSFPNDAPLHHTDGNGPVf--PLSVYLAMAISALLGFGDAILQTQIYSYIAKYYQRDSSSVFSIFRFSSGIASTGIFFAA 351
O61865       428 PLLNIYYYVIGIPILCIIASVCFF 451 Caenorhabditis elegans
Q18251       408 SFLFLPSQLLILTIGCVASTFFFL 431 Caenorhabditis elegans
Q9XWR7       425 PYMTIYIWLCVLTIFLLIGTTCFV 448 Caenorhabditis elegans
2_pfamImport 372 PMVPLYFYTLGLPSLSIFAIFVFF 395
Q8BJ51       407 NYLLLHWQLLVMVIFGFFGTISFF 430 house mouse
Q21545       392 PVLQLYWHLVILVVTSLFAACCFF 415 Caenorhabditis elegans
Q9XV34       388 SLISLYWVLTILSIFSILALICFF 411 Caenorhabditis elegans
Q19932       393 KYFTLAGHLLLYGAFAILSAIAAV 416 Caenorhabditis elegans
1_pfamImport 352 QYFYLVHHMILLTISALLGGLAIL 375
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