1Y79,2O3E


Conserved Protein Domain Family
Peptidase_M3
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pfam01432: Peptidase_M3 
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Peptidase family M3
This is the Thimet oligopeptidase family, large family of mammalian and bacterial oligopeptidases that cleave medium sized peptides. The group also contains mitochondrial intermediate peptidase which is encoded by nuclear DNA but functions within the mitochondria to remove the leader sequence.
Links
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Statistics
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PSSM-Id: 396149
Aligned: 29 rows
Threshold Bit Score: 273.879
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1Y79_1 228 ALAEMRDRATREKLFIAGWTRaek-ndaNdtRAIIQRLVEIRaqqATLLGFPHYAAWKIADqmAKTPEAALNFMREIVPA 306 Escherichia coli
O25216 183 ALLHNPKRKIRKKSQKAFSKAleksrplL--TYILNMVRKDLlieTRLRKYDKKESFRHID--NQISQESVDSMIEIVNA 258 Helicobacter pylori
P47429 193 SLLENTNRGIRKACYEKWIEIywtnrnsL--SLSLVENYIQLenfAKLKNHPSYIAQTAFN--DEIEVGFIDFVYQQVAQ 268 Mycoplasma genitalium...
P54125 193 SLLENKDRGLREAAYKVWLEIywptrntL--SVSLVENYIQLetfAKLKKHPNYIAKTAFD--DEIDVAFIDFVYEQVAS 268 Mycoplasma pneumoniae...
O51264 193 LFLQNEDQKIRKEAFLRFYQKyknnentL--ANLIISDFKKNhfiAKTRRFQNTFSMQLFS--NNIDKKVYTNLIETVNE 268 Borreliella burgdorfe...
Q9Z947 213 LYMQSPDQELRRTAYLAQFQRyydyrntF--ANLLNGKVQAHlfeAKARNYPSCLEASLFQ--HNIPTTVYINLINETKK 288 Chlamydia pneumoniae
O84114 212 LYMQSTDRELRKNTYQKQCQRhhgyrlsL--ANLLNGKIQAHlfnAKARDYDSCLEAALFQ--NDISTSVVTTLIDTVKQ 287 Chlamydia trachomatis
P70922 228 NFLESENREVRKNAFDAVYKTygqykntM--ATTLSGTVKKDnfyARVKKYKSAREAALSN--NSIPEEVYDNLVKTINK 303 Bacillus licheniformis
Q53778 201 SLMESSDRTVRKEAYQAMYSTyeqfqhtY--AKTLQTNVKSQnfkARVHHYQSARQSALSA--NFIPEEVYETLIKTVNH 276 Streptococcus agalact...
P54124 202 SLMESKNRGVRKAAYKALYSNyeqyqhtY--AKTLQTNVKVHnlnAQIRSYDSARQAALAN--NFVPEKVYDVLMEAIHQ 277 Lactococcus cremoris

1Y79_1 307 ARQRASDELASIQAVIDKQqggfSAQPWDWafyaeqvrrekFD-LDEAQLKPYFELNTVLNegvfwtanqlfgikfverf 385 Escherichia coli
O25216 259 NFSLVHRYYHQKAQ----Ilg-hKLKDYDR-----------YApLND--ESITMTYSQALEevlkt-----------lka 309 Helicobacter pylori
P47429 269 FAKTFQAFIRLKKQIYKHVlkvnKVEPYDL-----------TLtLFK--TKKSYTIEQAKQdalkv-----------ldl 324 Mycoplasma genitalium...
P54125 269 FAPTFKAFQSLRKQIYKHVlkldKAQPWDL-----------SVpLFK--ASGDYTIEQAQTdalki-----------lap 324 Mycoplasma pneumoniae...
O51264 269 NLPVLNDYYEFRKK----VlnqeYLYHYDV-----------YVpLTKG-IIFKNSFEDACEkilks-----------lev 321 Borreliella burgdorfe...
Q9Z947 289 HTSLINRYFNLKKE----AlnlkEFHFYDV-----------YApISQT-TSKNYSYEEGVDlvcks-----------llp 341 Chlamydia pneumoniae
O84114 288 HTHLITEYFQLKQK----AlglsDFHFYDV-----------YApLVASEASRHYSYQEAVTlicds-----------lsl 341 Chlamydia trachomatis
P70922 304 HLPLLHRYIALRKK----VleldEVHIYDL-----------YTpLVKD-AGMKVTYEEAKDymlkg-----------lap 356 Bacillus licheniformis
Q53778 277 HLPLLHRYMKLRQK----VlgldDLKMYDV-----------YTpLSQ--MDMSFTYDEALKkseev-----------lai 328 Streptococcus agalact...
P54124 278 HLPLLHRYIELRKK----IlgitDLKMYGI-----------YTpLSN--LGYKFNYEDGVKkaeev-----------lai 329 Lactococcus cremoris

1Y79_1 386 diPVYHPdvrvweifdhnGVGL-ALFYGDFFARDSKSGGAWMGNFVEQstlnkthPVIYNVCNYQKpaagepallLWDDV 464 Escherichia coli
O25216 310 fsPEFHKi---------aSKAI-KEGWVDSHPKDFKQGGAFSHGGVPS-------AHPYVLLNYTG---------NRRDA 363 Helicobacter pylori
P47429 325 lgDNYIKi---------vKKAF-NENWIDWLADKNKYTGAYSISNVKGl------EHFFILMNFDK---------TKSSL 379 Mycoplasma genitalium...
P54125 325 mgSEYLEv---------vKEAF-RERWISWLPDKNKYTGAYSISNVKGl------DHYFILMNFDK---------TRASL 379 Mycoplasma pneumoniae...
O51264 322 lgNEYTKi---------lRNGLlKERWVDKYENTGKRSGAFSAGSYN--------GKPYILLNYKDe--------SIRDM 376 Borreliella burgdorfe...
Q9Z947 342 lgTHYVEi---------lRNGLlSNRWVDRYENKHKRSGAYSSGCYD--------SAPYILLNYTN---------TLYDV 395 Chlamydia pneumoniae
O84114 342 lgNDYVEt---------lRKGLtSDGWVDKYENTNKRSGAYSSGCYD--------SKPYILLNYTG---------TLYDV 395 Chlamydia trachomatis
P70922 357 lgEEYASi---------lKEGL-ENRWVDVYENKGKRNGAYSSGAYG--------TNPYILMNWHN---------NVNNL 409 Bacillus licheniformis
Q53778 329 fgEVYSEr---------vHRAF-TERWIDVHVNKGKRSGAYSGGSYD--------TNAFMLLNWQD---------TLDNL 381 Streptococcus agalact...
P54124 330 fgKEYKGk---------vKAAF-EQRWIDVEENIGKRSGAYSGGSYD--------TNAFMLLNWQE---------TLDDL 382 Lactococcus cremoris

1Y79_1 465 ITLFHEFGHTLHGLFARQRYATlSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRnaslfnkg 544 Escherichia coli
O25216 364 FTIAHEFGHMIHQELSKKQ-GV-LNMDTPLTTAETASVFSEMLFFEHLKKGLK--SDE-LLFMLAGKLEDIF-------- 430 Helicobacter pylori
P47429 380 NTLVHELGHSVHSWYASQHQSQ-N-IDPTIFYAEIASIANELLLCYYELQLYKN-NHKQLIASLLSQINHFF-------- 448 Mycoplasma genitalium...
P54125 380 NTLVHELGHSVHSWYASKYQTQ-N-LDPTIFYAEIASICNELLLCYHDIINYENRNPQQLIRSLMEQISHFF-------- 449 Mycoplasma pneumoniae...
O51264 377 FTLAHEAGHSMHSYFSIKNNPF-PHYNYSIFEAEIASIINEQILAEYLLKNET--DTNKIKYIKLTQIDDMI-------- 445 Borreliella burgdorfe...
Q9Z947 396 SVIAHEAGHSMHSYFSREAQPY-HDAQYPLFLAEIASTFNEMLLMEALSKSDQ--SKEDKIVIITKTLDTIF-------- 464 Chlamydia pneumoniae
O84114 396 SVVAHEGGHSMHSFLSHKHQSY-HEAQYPIFLAEIASTLNETLLMEFLLKQAP--SKEEKIAILSRSLDTVF-------- 464 Chlamydia trachomatis
P70922 410 FTLVHEFGHSVHSYYTRKHQPY-PYGNYSIFVAEVASTTNEALLGEYLLNNLE--DEKQRLYILNHMLEGFR-------- 478 Bacillus licheniformis
Q53778 382 YTLVHETGHSLHSTFTRENQPY-VYGDYSIFLAEIASTTNENILTETLLKEVK--DDKNRFAILNHYLDGFK-------- 450 Streptococcus agalact...
P54124 383 FTLVHETGHSMHSAFTRENQPY-VYGNYPIFLAEIASTTNENILTETLLKESK--DDKERFALLNHWLDSFR-------- 451 Lactococcus cremoris

1Y79_1 545 YEMSELLSAALLDMRWHCLEENEAmqD---VDDfELRALVAENMD--LPAIPPRYRSS----YFAHIFg--gGYAAGYYA 613 Escherichia coli
O25216 431 STLFRQVVMTNFERRIHEMDEEl---DtkdFDR-IWFEENQRMFE--KSVKLTKNYHLwwsy-------iphFIHSPFYC 497 Helicobacter pylori
P47429 449 GATTRQIMFSQFEKDTLYLIRVNQkpDfktLIK-IYANTAVKYQGfkPEVVANKLKKTqyqkSLSHIIaiphFYAGNFYV 527 Mycoplasma genitalium...
P54125 450 GATTRQLMFSQFEQDTLKLIQQNQkpDfktLVE-IYGKTAIKYQAanADAITKKLKQTkyqkSLAYITsiphFYAGNFYV 528 Mycoplasma pneumoniae...
O51264 446 STFFRQTMFAEFEYIIHEMISKEEpvVketLTE-TYMNLLKKYFG--PSLKFDELSPLeclr-------iphFYS-PFYV 514 Borreliella burgdorfe...
Q9Z947 465 ATLFRQTFFAAFEYEIHSAAEQGTplTeefLSA-TYGNLQKEFYG--GVVTSDSLSALewar-------iphFYY-NFYV 533 Chlamydia pneumoniae
O84114 465 ATLFRQTLFAAFELEMHSAAEQGLplTeefFSQ-SYEKLQRLFYG--DCITFDEHSCIewar-------iphFYY-NFYV 533 Chlamydia trachomatis
P70922 479 GTVFRQTMFAEFEHLIHTKAQEGEplTpelLTK-VYYDLNKKYFG--DGMVIDKEIGLewsr-------iphFYY-NYYV 547 Bacillus licheniformis
Q53778 451 GTIFRQTQFAEFEHAIHVADQEGQvlTseyLNN-LYAELNEKYYG--LTKEDNHFIQYewar-------iphFYY-NYYV 519 Streptococcus agalact...
P54124 452 GTVFRQSQFAEFEQKIHEADAAGEvlTseyLNS-LYGEINEKYYN--LAVKGNPEIQYewar-------iphFYY-NFYV 520 Lactococcus cremoris

1Y79_1 614 YLWTQML--ADDGYQWFVEQGglTrenglRFREAILSRGNSEDLERLYRQWRGKAPKIMPMLQHRGL 678 Escherichia coli
O25216 498 YAYSYGQllTLALYGLYKKSD--Ake-fvKTYTEFLSLGGSKSPKELVSMFGFDIDSKEFWEIGMQE 561 Helicobacter pylori
P47429 528 YKYAIGQvaGILVAKKINS-G--Dkk-mkDNYFKFLSSGSSLAPLETIKLLGIDLTSPQPWQEAHNE 590 Mycoplasma genitalium G37
P54125 529 YKYAIGQvvGTLVGKKLSA-G--Dsn-mlAAYKRFLSSGSTLPPLETIKLLGIDLTQPEPWQEAHAE 591 Mycoplasma pneumoniae M129
O51264 515 YQYATGIaaALSIYKGIKE-N--Kkd-avENYIKFLKTGGSKYPLDSLNITGVDLTKKATIENTINI 577 Borreliella burgdorferi B31
Q9Z947 534 YQYATGIiaALSFAEKILT-Q--Epg-alELYLKFLKSGRSDFPLNILKKSGLDMTTSAPLDKAFAF 596 Chlamydia pneumoniae
O84114 534 YQYATGIiaSLCFSERILS-G--Eeg-aqEAYLTFLRSGGSDFPIEILKKSGLDMTSSAPMLKAFSY 596 Chlamydia trachomatis
P70922 548 YQYATGYsaAQALSSQILK-E--Gkp-avDRYIDFLKAGSSQYPIDVLKKAGVDMTSPEPIEAACKM 610 Bacillus licheniformis
Q53778 520 FQYATGFaaANYLAERIVN-G--Npe-dkEAYLNYLKAGNSDYPLNVIAKAGVDMTSADYLDAAFRV 582 Streptococcus agalactiae NEM316
P54124 521 FQYATGFaaATFLAEKVVH-G--Ste-drQKYLEYLKAGSSAYPLEVIAKAGVDMESTDYLDAAFEL 583 Lactococcus cremoris
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