7CGP


Conserved Protein Domain Family
Tim29
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pfam10171: Tim29 
Translocase of the Inner Mitochondrial membrane 29
This is a family of proteins conserved from nematodes to humans. The function is not known. However, family members such as the import inner membrane translocase sub-unit Tim29 (C19orf52) found in human, is shown to be required for the stability of the TIM22 complex. TIM22 complex imports and inserts multi-pass trans-membrane proteins into the mitochondrial inner membrane by formation of a twin-pore translocase with components in the outer and inner membranes. TIM29 is integrated into the inner member with the C terminus exposed to the inter-membrane space and able to contact the translocase of the outer membrane. It is required for complex stability and for the addition of the TIMM22 protein to the complex.
Links
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Statistics
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PSSM-Id: 462977
Aligned: 32 rows
Threshold Bit Score: 173.949
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7CGP_C        24 KPGvwaRLGSWARALLRDYAEACRDASAEARARPGRAAVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATRN 103
XP_004929618  26 KGTiieKWADYWKNLFIDYRQMLQDLRSDIQDDPMKAMKWTTGIITFYLLSRNNPTECDFKDNLKIINNEVGLVSEECLN 105
XP_002071750  28 KGTvveKWVNYWHGLVRDYSEVTIGVVKESYAKPKKALAYATGITLLYKAVENNPDHEAFMTILRRNSNRMITVPTERQN 107
Q9W4R8        28 KGTfveKWVQYWNGLVRDYTEVAVGVVRESYTKPKKALLYGTGMLFMYQANLKNPGEEAFMTLLRGATNRMITVPVELQN 107 fruit fly
XP_001990904  28 KGTtveKWANYWKGLMSDYAEVATSVVKESYARPKRTLIYGTAIVALYQMAKNNPDQYAFSSLLRTQTNRMITLPPEQQN 107
XP_002431373  30 KGTvveKWIKYWEGLINDYADVFRDSIKESKSKPYKTGLLALSGCFLTYAVYNNPTEQDFRDSVIYYQNLFGLVGKPVRN 109
NP_001313596  34 RGTileRWKQYWESVAKDYYESTVGIGTYARANPIKSSLAVVTASCAYYCASTNPDEHSYRSEILDCANTMLYISPAVRN 113
XP_011419369  18 KGGkleKIGSFIYSIINDYKVVAQETIQDCKDRPVKASLYISLLSFVGVLYKTNPTERDFRQELIEDGQEMLLIGEPIRN 97 
XP_001626519  24 ENLkqrKIGRSAFAVYVDYKAVFVDFFKGARSKPLRTSLGLGLLGFGYVVYLNNPDDDSYNDTLLDNANELLQVGERIRN 103
XP_002636731  14 GTSik----eYFQRMGNDYATVARETAAGAKERPLKAGIVLSGLGFLTYAYRTNPTELEMLDYLCERRQQMVLVPNTEHN 89 

7CGP_C       104 RESEAFVQRLLWLRGRGRLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQP-RWTDFPGRVLDVGFVGRWWVLGAWMRDC 182
XP_004929618 106 PKAVEHLRFLDTCYNQEVIHYRSLGILSVMYTSELSNSCDLYRAHCTYTKP-TYFSFPSRIVDIGFMGKWWNLFIKSTNY 184
XP_002071750 108 PEASQYLVTLERAINQKKLRLLSLGAFTLLWVDLYDEDDCTYPAICEYTTV-SWLNFHERVIDVGFWNEFWRLRWKMRNY 186
Q9W4R8       108 PVSADYLLTLERAINQKKLRLLSLGICTILWVDLYDEDDCTYPAICEYTNV-GVFNFHERIIDVGFWNQYWRLKWKMRNY 186 fruit fly
XP_001990904 108 SESSDYLVMLERAINQNKLRLLNLGICTLLWVDMFDEDDCTYPAICEYTTV-NYLSFHERIIDVGFWNQYWRLKWKMHNY 186
XP_002431373 110 PGVDVYLKSLENSFNFKVIRRLSLGIFCFIWIDNYDEALGLYKAQCKYLKP-RYLTFYERVIDVGFLNKFWILEKNMRDY 188
NP_001313596 114 PSTVKHLEYIEKCYNVGVVKRLNMLLFSVIWIDEFNNDIQAYKANCKYLKP-SVLSVHQRAVDIGFLNVWWRLKKIMVDY 192
XP_011419369  98 VNTDKYLCRLLEAQRDGRLKYQSLLLFSIIYFDNLSKESDLYEARCKLIKP-HWMDFHKNIVEVGILGRFLNLRKAMLDY 176
XP_001626519 104 PSSDVYTQEMLQLFYQGKLRRQSFGLFSLMMQTEFGKDCDLYEKHCYYTKT-RWVDLWKYVRDFGILGHWYKLETAMIDY 182
XP_002636731  90 PTTTKELVSRDFLLSQKRLHHYNLWFFSLLVAGDYNKNLRIYSSQDSNLKDwPWTELWRNIVDVGALGKWYWMDNAFVDY 169

7CGP_C       183 DIND 186
XP_004929618 185 DVNY 188
XP_002071750 187 DINY 190
Q9W4R8       187 DVNY 190 fruit fly
XP_001990904 187 DVNY 190
XP_002431373 189 DINP 192
NP_001313596 193 DVNP 196
XP_011419369 177 DVNP 180
XP_001626519 183 DVNQ 186
XP_002636731 170 DINT 173
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