1WJR,2JTF,4C5E,4C5E,4C5E,4C5I,4C5I,4EDU,4EDU,4L59,4L59,4L59,4C5I,4C5E,2PQW,2RHI


Conserved Protein Domain Family
MBT
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cd20088: MBT 
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malignant brain tumor (MBT) repeat
The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).
Links
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Statistics
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PSSM-Id: 439080
Aligned: 30 rows
Threshold Bit Score: 59.1916
Created: 24-Jun-2015
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Comment:Not all MBT repeats contain the semi-aromatic cage that facilitate binding to methyllysine residues
  • Structure:2PQW; Homo sapiens L3MBTL1 in complex with H4k20me2 peptide through its second MBT repeat, contacts at 4A
  • Structure:4EDU; Homo sapiens SCML2 in a complex with histone H2A modified peptide through its second MBT repeat, contacts at 4A
  • Structure:2RHI; Homo sapiens L3MBTL1 in complex with H1.5k27me2 through its second MBT repeat, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #  #             # #               #  #     #                  
1WJR_A      12 ITVGSLIELQDSQNp-----------fQYWIVSVIENvGGRLRLRYVGLedtesYDQWLFYldyRLRPVGWCQ 73   human
4C5E_A      38 LGVGMKVEVENTDCdsieviqpgqtptSFWVATILEIkGYKALMSYEGFdt-dsHDFWVNLcnaEVHSVGWCA 109  fruit fly
4C5E_A     158 FRLGLNLECVDKDRi-----------sQVRLATVTKIvGKRLFLRYFDSd----DGFWCHEdspIIHPVGWAT 215  fruit fly
4C5I_A     159 FKPCMRVEVVDKRHl-----------cRTRVAVVESViGGRLRLVYEESed-rtDDFWCHMhspLIHHIGWSR 219  human
4C5I_A      46 ISENVRVEVPNTDCslp--------tkVFWIAGIVKLaGYNALLRYEGFendsgLDFWCNIcgsDIHPVGWCA 110  human
2PQW_A     146 FQVGMKLEAVDRMNp-----------sLVCVASVTDVvDSRFLVHFDNWdd--tYDYWCDPsspYIHPVGWCQ 205  human
Q9UHJ3     162 IAPGSRLECQAFQDs-----------lSTWIVTVVENiGGRLKLRYEGLessdnYEHWLYYldpFLHHVGWAA 223  human
KHJ44253    99 FQVGQWLEATNVMTn-----------gEIFPASIVQIcGRLLRIQFDGYse--kVLHWFDSgspDIYPVGWCE 158  pig whipworm
KHN78413   712 IKVGQWMELQDVRNp-----------cEVRVVQVLANrGGLLTLGHGQR-----HENILFTn-eRCHELGWAQ 767  dog roundworm
VDD85751   136 VKVGQYFELQDRIYp-----------cKVYIAQVFENrGGLLLIGRNGAkpdldRPVRVFVtdeRCHAIGWLE 197  human pinworm

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