1T77_A 137 TQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEE-LDLTLP------T-------------------- 189 human CBZ37434 4245 lvRWATGSLSNYEYLRFLNEAAGRTNRDLNQYPVFPWVLADYTSAT-LDLEAA------S-------------------- 4297 Leishmania do... XP_951600 2824 lagWGGRSVSTFEYLFFLNRAAGRTILDYNQYPIFPWVIADYRSST-LDLSSD------S-------------------- 2876 Trypanosoma b... XP_001347923 586 QEKWSQGYISNYIYLDFLNCIGGRSRKDFSQYPIYPWVISSYTTNEkLEYDNK------E-------------------- 639 Plasmodium fa... NP_974804 348 fDKWWKGELSNFEYLLVLNKLAGRRWGDHTFHPVMPWVI---------DFSKKpendsdS-------------------- 398 thale cress XP_002664681 337 vldWVNGQVSNFQYLMELNRLAGRREGDPNYHPVLPWVV---------DFTVPy-----G-------------------- 382 zebrafish CAG08933 166 vldWVHGRVSNFCYLMELNRLAGRRQGDPNYHPVLPWVV---------DFTVP------F-------------------- 210 spotted green... NP_609535 345 TEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVT---------DFSGR------G-------------------- 389 fruit fly XP_317789 335 CEMWCHGQLSNFDYLTILNNLTGRRVGCAEFHHIMPWVT---------DFFSR------S-------------------- 379 Anopheles gam... XP_647543 475 MNKWINGELSNFNYLMILNHLAHRHIGDPMNHPVLPWVI-DFTTSP-INIDND------Ndsrddvdnssssnnnnnnnn 546 Dictyostelium...
1T77_A 190 --------N--FRDLSK-PIG-A-LNPKRAA---FFAERYESWe----------------------------dDq----- 220 human CBZ37434 4298 --------S--FRDFAY-PMG-A-QTETRRAtvaRLFENTHELc----------------------------dAd----- 4331 Leishmania do... XP_951600 2877 --------T--YRDLSR-PMG-A-QTKERRR---SVEDLYQQMm----------------------------eVaqqlgd 2912 Trypanosoma b... XP_001347923 640 --------I--YRDLSK-PVG-C-LNKNRLN---SLIEKMHDHd------------------------------------ 667 Plasmodium fa... NP_974804 399 --------G--WRDLRKsKWRlA-KGDEQLD---FTYSTFE--------------------------------------- 425 thale cress XP_002664681 383 --------R--FRDLKKsKFR-LnKGDKQLD---FTYEMTKEAl----------------------------aAvsgsgg 420 zebrafish CAG08933 211 --------Gk-FRDLRRsKFR-LnKGDKQLD---FTYEMTKEAlaaavgngvggsgvgdlsgsvgtggggqpeHl----- 272 spotted green... NP_609535 390 --------GgaWRDLTKsKYR-LnKGDVHLD---LMYAHASQHg----------------------------sAdgsyq- 428 fruit fly XP_317789 380 --------GqaWRDLKKsKFR-LnKGDAQLD---LTFQAAAQLagsgaq------------------eqtgtsPa----- 424 Anopheles gam... XP_647543 547 edqsgktvG--WRDLTKtKYR-LnKGDEQLD---FQFFNTGNSt----------------------------tLg----- 587 Dictyostelium...
1T77_A 221 ----------------------vP-------------------------------KFHYGTHYSTASFVLAWLLRIEPft 247 human CBZ37434 4332 ----------------------tGks----------------------------yPFHHGTHYSTSGGVLYFLIRVQPft 4361 Leishmania do... XP_951600 2913 gg--------------vaameltQ-------------------------------PFHHGTHYSTSGGVLYYLIRMEPft 2947 Trypanosoma b... XP_001347923 668 --------------------------------------------------------YFYGSHYSTLAYVVYFLIRLYP-- 689 Plasmodium fa... NP_974804 426 -----------------------F-------------------------------PHHVSDECLSELAVCSYKARRLPl- 450 thale cress XP_002664681 421 snyppdlggpvvpggpgqsdhlhV-------------------------------PHHISD-VLSDITYYVYKARQTP-- 466 zebrafish CAG08933 273 ----------------------hV-------------------------------PHHISD-VLSDITYFVYKARQTP-- 296 spotted green... NP_609535 429 ------------------aigdqA-------------------------------PHHVSD-FLSEITYFVYMARRTP-- 456 fruit fly XP_317789 425 ----------------------aI-------------------------------PHHVSD-VLSEITYYVYMARRTP-- 448 Anopheles gam... XP_647543 588 ----------------------dDsmgggigsigstggitnssnngggggsgnsgKAHHISDILSELTYYSYLARRTSvp 645 Dictyostelium...
1T77_A 248 TYFLNLQGGKFDHADRTFSSISRAWRNs--QRDTSDIK-----E-----LIPEFYYLPE-MFVNfNNynlgVMDDGTVVS 314 human CBZ37434 4362 TYARLFQGGDFDLAMRLFDSVAASFTSc--VTGPADCK-----E-----LIPEFYVNGG-FLANaDHlnlgTKSDGQAVG 4428 Leishmania do... XP_951600 2948 TFARIFQGGDFDVASRLFDTIDGSFQSc--VNGPADCK-----E-----LTPEFFLDGS-FLVNmNRcnfgTKSDGTAVD 3014 Trypanosoma b... XP_001347923 690 ECQLKLQSGKFDTISRMFLSLESTYHTa--LNANSSFI-----E-----LIPEFYEDDEsFLKNyLNi---ITNEGN-IN 753 Plasmodium fa... NP_974804 451 --------------SVLRKAVRSVYEPneyPSDMQRLYdwtpdE-----CIPEFYCDPR-IFCSlHP----------SMS 500 thale cress XP_002664681 467 -------------KSVLCSHVRSQWEPneyPASMERIQswtpdE-----CIPEFYRDPS-IFRSiHP----------DMP 517 zebrafish CAG08933 297 -------------KSVLCSHVRSQWEPneyPASMERMQswtpdE-----CIPEFYTDPS-IFRSiHP----------DMP 347 spotted green... NP_609535 457 -------------QSILCAHVRPIWVPaeyPVSIQRLQ-----EwtpdeCIPEFYSDPM-IFKSiH----------EDLP 507 fruit fly XP_317789 449 -------------KAVLCKHVRPIWVPaeyPATIQRLF-----EwtpdeCIPEFFTDPS-VFKSiH----------EDLH 499 Anopheles gam... XP_647543 646 LL------RRF---------VRTNYEPneyPATMERLYrwtpdE-----CIPEFFTDST-IFKSiH----------SDMP 694 Dictyostelium...
1T77_A 315 DVELPPWAKT-S-EEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVn------------- 379 human CBZ37434 4429 DVRLPPWSKN-SrQVFTAVMRYALECPYVVAHLHQWIDLVFGVRRRGPLALERYNVFQRMTYGEEVvq------------ 4495 Leishmania do... XP_951600 3015 DVKLPPWAKD-SaQVFTAVMRYILESDRVAHSIHHWIDLVFGVCRRGKLAVDCHNVFQRMTYGEEVvk------------ 3081 Trypanosoma b... XP_001347923 754 DVILPKWC-S-SpKEFLIFMKNALESNYVNQNINSWIDLIFGYKQNGHNAKECFNLFHPLTYMHSIlneklsrdynnkdn 831 Plasmodium fa... NP_974804 501 DLAVPPWA-S-SpDEFIRLHRDALESPHVSSLIHHWIDITFGYKMSGHAAITAKNVMl---------------------- 556 thale cress XP_002664681 518 DLDVPPWC-N-SyEEFIAVHRQLLESREVSQQLHHWIDLTFGYKLSGKEAIKAKNVCLHLVD------------------ 577 zebrafish CAG08933 348 DLDVPSWCK--SyEDFIEVHRRLLESREVSQHLHYWIDLTFGYKLSGKEAIKAKNVCLHLVD------------------ 407 spotted green... NP_609535 508 DLELPAWA-T-CpEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVD------------------ 567 fruit fly XP_317789 500 DLEIPSWS-S-CpEDFVLKHRELLESQYVSERLHHWIDLTFGYKLTGTAAVRSKNVCLSLV------------------- 558 Anopheles gam... XP_647543 695 DLQLPDWVPNqStQEFIKIHMNALESDHVSKQLHSWIDLTFGYLLSGEEAIKAKNL-------ALMd------------- 754 Dictyostelium...
1T77_A 380 -------------------lNSITDPVLREAVEAQIRSFGQTPS-QLLIEPHPPR 414 human CBZ37434 4496 ------------------alKNAETPHDCDVIIAEVDNFGQTPL-QLFQERHPSh 4531 Leishmania donovani BPK282A1 XP_951600 3082 ------------------alKESQNSRDIDVIVAEVDNFGQTPM-QLFQEHHPPq 3117 Trypanosoma brucei TREU927 XP_001347923 832 yerynaeqentfeqnfnqniKDLITTMSSKALKTQLHEFGQCPY-QIFKQPHVSK 885 Plasmodium falciparum 3D7 NP_974804 557 --------------------SSSEPTVPRSVGR----------R-QLFFRPHPVR 580 thale cress XP_002664681 578 -------------------------------NHTHLTSYGVV---QLFDHPHPPR 598 zebrafish CAG08933 408 -------------------------------NHTNLTTYGVV---QLFDQPHPPR 428 spotted green pufferfish NP_609535 568 ----------------------------------QHRNLSQRGIvQLFASAHPPR 588 fruit fly XP_317789 559 ------------------------DKHQNLCHRGVV---------QLFSCPHPLR 580 Anopheles gambiae str. PEST XP_647543 755 --------------------------------TTIPRNNGIV---QLFNHPHPkk 774 Dictyostelium discoideum AX4
Jiyao W et al.(2023). "The conserved domain database in 2023.",