Conserved Protein Domain Family
7TM_GPCR_Srsx

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pfam10320: 7TM_GPCR_Srsx 
Serpentine type 7TM GPCR chemoreceptor Srsx
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Statistics
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PSSM-Id: 255903
Aligned: 23 rows
Threshold Bit Score: 232.099
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9XVI7        14 MVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELKTLI-FRLrFQSLNGRECFLYNIPYSLAIMFQSWLF 92  Caenorhabditis ...
O01473        19 CCIGLFGNINLIVATCRYKSLRTKLGCLIMISTISHTICLVSELISVK-LKLrFTQTHRDECFRFVVVYMFAVLFQSTLF 97  Caenorhabditis ...
Q9U1X1        20 SIIGLIGNMTIVLATVISKRLQSRCNILIGLLALSDVVVCTYLIHLRVlMFLdMYMLTSTQCFLLSAYGLFALNMQSSLC 99  Caenorhabditis ...
Q18767        20 IPVGIFSNVIMIICFFVNPRLRSPFHILLTLTCLADGIHVCGQIIFVF-QMLtNTYSYQSTCYMLNVLPVIGLTLAAPLL 98  Caenorhabditis ...
Q6BES9        19 AIVGVVGNGIMILVFLKESKFKLPVNYLITLNCLADLFHVSGHFVFNY-QLFnDDKSSQAACFFMMIHTVIGYCISGPLL 97  Caenorhabditis ...
XP_002636479  19 AVVGIIGNGIMVMVFMKESKFKLPVNYLITLNCLADLFHVSGHFVFNY-QLVtDETSSQANCFFMLFHTVIGYCISGPLL 97 
Q19607        20 SIVSCTGNSIMIILFIKEKNFHSPCHYMITFSCLADMLHLCGHFVFNY-HIFaDVTDTQANCYWMLFFTSIGKTMSNPLI 98  Caenorhabditis ...
Q7JLH4        19 ALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMLHLCGHFVFNF-QLFyQGPGSQELCFWLLLPSTIGLLMSGPLL 97  Caenorhabditis ...
Q18770        20 SVIGIAGNFVMLLCSFRTKRFRSPCYILITVTCVADAIHISGQFPFCV-HLFgNLTSTQAQCFYMLTVPLIGLTSGGPLI 98  Caenorhabditis ...
Q18766        20 SVIGVIGNVIMVICTIRTKRFRSPCHLLICATCIADLLHVCGQFPFCV-HLFgNLTSSQAQCFYILTIPIVGFTTGGPLI 98  Caenorhabditis ...
Q9XVI7        93 LSMALDLCFCIMIPIKHMLWPKTK--YILIMCIMPTCCALIVFFVNFIFVTEE--DAPYCAYMLTMDDGVF---EIISTS 165 Caenorhabditis ...
O01473        98 LMMAIDLLLAVIMPIRHKLWQRGP--YLLILCTPPVIFSTFAIFIEQLYINHE--NLLMCTVSLAAPRKVRfwgTIITFS 173 Caenorhabditis ...
Q9U1X1       100 LIIGLDRLYNVTYPLRYSQLPNS---FYIALFLFCVGFSVLITYSGYSYASDSe-IVLVCLPPTAYTDKSR---IIWIGS 172 Caenorhabditis ...
Q18767        99 MQIGLDRLLAVSFPIRYRELQFQKlfYTSIHLIFPILYTISILYLGFLERNNE---QVKCAIPTALAGISF---KVFTLS 172 Caenorhabditis ...
Q6BES9        98 LAIGIDRIIACRFPITYRLLLSYGsvYLGIQLIFPITFTSALMIYGYQFIDYN--TQIICMAPLALPRQAF---GYFTYS 172 Caenorhabditis ...
XP_002636479  98 LAIGFDRLIACRFPINYRTLLSNGtlYLCAQLLFPVAFTTVLIGYGSQLIDFN--TQIVCMAPLALPRQAF---GYFTYA 172
Q19607        99 LMTGIDRLIACKSPVLYRALLERPnlYVCGQLILPTAYSSFLMVSGFLQRDTV--TQIYCAVPAAFAGTAF---SKFNTS 173 Caenorhabditis ...
Q7JLH4        98 LSMGIDRLIACQLPVFYRQLCSRPsfYLCIQLSFPIIYTSYITVISFLQRDSE--TMVICQVPLAMSGNSF---ELFNQG 172 Caenorhabditis ...
Q18770        99 LSMGIDRLIAVKFPTRYRYIQDEPtlYICAQLMFPISYAGIFLLYGFLVRDTNfkNQIICANPLALNGTAF---QMFTYS 175 Caenorhabditis ...
Q18766        99 LSMGIDRFIAVKFPTKYRYYQEEPkfYVLGQLAFPLLYSVFFLVYGFIVRDTNvkNQLVCSNPLSLNGSSF---QMFTYS 175 Caenorhabditis ...
Q9XVI7       166 VVACNILTLLITIVSVFV-----AIRKSQDmrnhrhssvtrrnsTVEERRKVFRSTFYMMSIYIFCWMTSSICFRVLFYM 240 Caenorhabditis ...
O01473       174 TVLLAVALILVTAVKVHI-------NEQSSsspfirhsststktSRSSEVKLLKSLATLIFFFICSWTMSVILFHVAMYF 246 Caenorhabditis ...
Q9U1X1       173 NFIIAILVIFVYGGAQIRcrilrARHVHEQ--------------SMDAVNRLLKSLSIVVTIYVCTWFLTISSLVVSQLI 238 Caenorhabditis ...
Q18767       173 SHAIYVSIILAYLMTAIL-----LKFHDT----------------SSRFKAVFKSIGVTVGIVLFGWAITTVSNTFGLFV 231 Caenorhabditis ...
Q6BES9       173 SNIINVKIVIVYAYTYFV-----LRGYKER--------------DANRMRYVFKSIALTVIVVLIGWTTVTIGNTIALGV 233 Caenorhabditis ...
XP_002636479 173 SNVINVAIVIVYIYSYVV-----LRGYKER--------------DARRMKYVFKSISFTVVIVLVGWTTVTIGNTVAIGL 233
Q19607       174 GIFINIAIVIVYFFTFLQ-----LRTYAG----------------ATQMKVVFRSILWTVIFVIIGWSSVTIANQFAI-F 231 Caenorhabditis ...
Q7JLH4       173 GLLINVAVVLIYFTTYIK-----LKKVTA---------------NASQLKTVFKSILYTVIFVILGWCTVTVVNIGCIHL 232 Caenorhabditis ...
Q18770       176 SGIIYVAVFIVYLSVYIL-----LKSNKA----------------SARFKSVFRSLAVTVGLVMFGWVSTTTANTLSYSI 234 Caenorhabditis ...
Q18766       176 SAVIYVAVVLVYSAVYLM-----LKSNKA----------------SARFKNVFRSILVTVGFVLLGWVTTTTANTLAFVV 234 Caenorhabditis ...
Q9XVI7       241 FENETNIVPYMPYLAIITMPNFCQAYFVTYFRSPRFRKAYREHF 284 Caenorhabditis elegans
O01473       247 DSSIGYQ--FHKYTFILQLPTFCQNFFVTALRSPRYARVYREQL 288 Caenorhabditis elegans
Q9U1X1       239 TFSPPVTAEINRQLGWLVIINASLNFFVYLWRNSEYRKAFIRLY 282 Caenorhabditis elegans
Q18767       232 TDDMEVYNLIQMYSGITVNIAISSNLIIFYTINPEYQLTVKMLM 275 Caenorhabditis elegans
Q6BES9       234 IEDRHTSEIISIHAGFGVNISCSINVIVFYAINSEYRSAIRRLF 277 Caenorhabditis elegans
XP_002636479 234 IENQRISEIVSIHAGLGVNISCSVNVFVFYAINSEYRSGIRRLF 277
Q19607       232 AKDAATRKLISIYAGIGVNLACASNIFVFYAINTEYRNAIRRLF 275 Caenorhabditis elegans
Q7JLH4       233 VENIENQHIISIYAGIGLNLACVSNVFVFYTINSEYRSAIRKLI 276 Caenorhabditis elegans
Q18770       235 SDSPYTAQLIQMYAGITVNAAAASNVFVFYGINSEYREVIKSLF 278 Caenorhabditis elegans
Q18766       235 TSDLFTIQLIQMYAGITVNFAAASNVFVFYAINSEYRSVIKTMF 278 Caenorhabditis elegans
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