Conserved Protein Domain Family
MFS_MFSD8

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cd17326: MFS_MFSD8 
Major facilitator superfamily domain-containing protein 8
Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 340884
Aligned: 33 rows
Threshold Bit Score: 254.056
Created: 14-Mar-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter

cd17326 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd17326 is a member of the superfamily cl28910
cd17326 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  ##  ##  #                                   #                         
Q8NHS3        39 IRILYLTMFLSSVGFSVVMMSIWPYLQkid--ptADTSFLGWVIASYSLGQMVASPIFGLWSNYRp------RKEPLIVS 110 human
Q19845        42 IYLAGSCAFIQATQFAIFFTSMYPYILtle--hnVTQTSFGIVVAMYSVSQAIFSPVFGFWSNRIg-----qVRFPLIVG 114 Caenorhabditis ...
NP_001022903  48 IYLLTAIGMFCGIQFSIFFPTLWPFLNtvd--ptASASFFGFITAAFSVGQGLASPVFGYWMNKAk-----sVRQPLVFG 120 Caenorhabditis ...
NP_505586     11 VYLMGVFSLIQNTQYSIYLTSMFSYLKkld--atATESQFGWIMATSSLGHCIGCFVLGWWNSRGr-----kSSPPMHCG 83  Caenorhabditis ...
XP_009295888  11 FITIGLTFLLSGIEYAVILPTIWRYLQll----eAPPYFLGLGLSAFSFSGLVTGPVFGHWSDKTr-----tTKTIILFS 81  zebrafish
NP_001256536  12 VYLCGYFSLVVYFQYAIFTTIMYTYMTkld--psVGPTSFGLAVTLHGIGHCLGALAAAWWTKKRy-----kGKKPMCVG 84  Caenorhabditis ...
ERG81101     129 VRLIAAILFLGCIQMFVIGMSEWPYMQeid--keATSTFFGYVGSVSALGHAICAPLMGYWSSATg-----qTKNPMIAG 201 pig roundworm
EPB73711      24 IYVISAFAFTDALQFAFFVWTFWPYVQqld--psISASFIGLIMAVSGVGEAVAAPILGYWTNRTg-----vVIPPLVAS 96  Ancylostoma cey...
NP_505339     35 IIVTGIVSCLISVENSVLGMGEWPYMKeid--ndANAQFFGVTQSASKCAHAVFALVFSIWSFKAr-----sVKYPMIVS 107 Caenorhabditis ...
NP_587686     47 PFISAALMLLNNTILCISFTIVVPTSErfvqhlgGGNGLSGVIIGLPTITALVLLYPMLRFSTPKaakgytiYRRPYTMS 126 Schizosaccharom...
Feature 1                                            ## ###  #                    #  ##  #       
Q8NHS3       111 ILISVAANCLYaylhipa-shnkyyMLVARGLLGIGAGNVAVVRSYTAGATSlqe--rtsSMANISMCQALGFILGPVFQ 187 human
Q19845       115 FIVMAFGNITYlslqyls-snhlyvMMLARLIAGGGTGNMSLLRAYASTASTskd--rsrAIACVSGGIALGTMMGPGLQ 191 Caenorhabditis ...
NP_001022903 121 ISVMILSNIIFcfveafaekerrwvMMVARFFIGVGAGTIGVMRAYAATASSlkd--rarAITFIQASYVIGMTLGPGIQ 198 Caenorhabditis ...
NP_505586     84 FLLMLASNLVYllvdsvpsdwvahvMMVSRLLGGFGMGNSSPMRTCASFHSThsd--rskAMASISGGRSVGTVVGPGLQ 161 Caenorhabditis ...
XP_009295888  82 NVFEIVGNFMYfmgy------skwlLLSSRLVAGIGAGAGSSIFGFLTRTTLpde--rarVFAAVMACRQAGLLIGPAFN 153 zebrafish
NP_001256536  85 YLLMLLSNCLFlladhvpaetsafyIMLCRFLGGLGMGNTSTLRTTLTAHSMsdd--rakAMSVFIGGRALGLILGPGLQ 162 Caenorhabditis ...
ERG81101     202 RLIALVGCFLYicvemfp-rdrryvMLTCYTIFGISMSSVSVMRGYVAKISTptd--rarAISAFGLATMLAVTVGPMFQ 278 pig roundworm
EPB73711      97 VVMSIVGNVIYmclnnvpvplrkcgLLVSRFLNGAGSGNRGTFFAYIAAASEptd--rarAMALSGGGALIGLNVGPAVQ 174 Ancylostoma cey...
NP_505339    108 RFIAIFACTIYlsveyvp-tgkryaLMCVYILIGVSNSACTILRGYLVMCSSsed--rprAFAVIGLSVIVSLIVGPVLQ 184 Caenorhabditis ...
NP_587686    127 CISCIIGHIMYaladka---ksvalILVSRIFTGVACTMFLYHKRYFTDKALisikyrtsMGVVNSVMATLGLTAGPFIG 203 Schizosaccharom...
Feature 1                                                                                        
Q8NHS3       188 TCFTFLGekgvtwdviklqinmYTTPVLLSAFLGILNIILILAILREhrvddsgrqcksinfeea--------------- 252 human
Q19845       192 LLFSPLGenginil--glnisiYTSPALFCLILNVTGLLIVKLAFVEkyiinhgknivqdeen----------------- 252 Caenorhabditis ...
NP_001022903 199 VAFTPIGypglskg--vfhvdmYTSPAWFASIISLLSVIFIFIFLEEnyagldqgadted-------------------- 256 Caenorhabditis ...
NP_505586    162 LMFLPLGetgimilpgilslhsNNAPAFLGIVLTMIGFVSLIVLFEEeiaeesdktaiadfenq---------------- 225 Caenorhabditis ...
XP_009295888 154 IFLRLCDfklgp-----fivnkYTSPGLFMCGMWLLMQFAVMGLYWDippldsfaeqqmplrevrgeedeplmsledddr 228 zebrafish
NP_001256536 163 LIFLFLGdtglqli-gplhihsHNAAAFISIVLNISAIVALFTVYHEierngnscsqrsve------------------- 222 Caenorhabditis ...
ERG81101     279 MFFTTLSfpginlvagklwlniYTGPIYVALIANIASLILIIFYFKEkhfdrpatnnrkplerrps-------------- 344 pig roundworm
EPB73711     175 MLFTWIGsdgvdvg--fmrismYTAPAILAIVINLACIVLLLVFLKDgldrftasdsdsvstysiaaa------------ 240 Ancylostoma cey...
NP_505339    185 LIFSGIAypgyevf-pgirfhvYSSPIWVALILTVVTTIIIWMYMTDvhrnssqnvdiqefislnq-------------- 249 Caenorhabditis ...
NP_587686    204 GLMAKSSmksqs-----diwneYTSGNWLMAFIWVGLFLFGFACFREvlspqtdvkeevveekhvi-------------- 264 Schizosaccharom...
Feature 1                                                                      #  ##  ###  #     
Q8NHS3       253 ------------------------------------stdeaqvpqgnidqvavVAINVLFFVTLFIFALFETIITPLTMD 296 human
Q19845       253 -------------------------------------gekkikklaspdfiaiLLCIITRFSQIFLNTTIESIGSAYTMM 295 Caenorhabditis ...
NP_001022903 257 ----------------------------------------sytamptfdtisvAVCVLTQFTLMFIITNLETIGSLYAKM 296 Caenorhabditis ...
NP_505586    226 -------------------------------------yntvkeeypksdivamLICMLTRFVQNFMQISIETLAPAMLMM 268 Caenorhabditis ...
XP_009295888 229 tavadsygslnpeqtetqlssqippsppespppdtsdpfenfsasreflreevVVLLTAQFITLFNQTALETMVTPLTQK 308 zebrafish
NP_001256536 223 ----------------------------------------ddenwprpdklamFVCMLTRYCQNFTYYAIETLAPAFMMM 262 Caenorhabditis ...
ERG81101     345 -----------------------------------qaraalttdmlsfsiplaLICIFIRMAATLTIVTINTTTSPLMMS 389 pig roundworm
EPB73711     241 ---------------------------------edsdlernsvktvrmdilaaVVCMWTRAARMLITANVESIGSPFSQV 287 Ancylostoma cey...
NP_505339    250 -----------------------------------lrkhyetlknsnlkwklvAVCLTVKISSTFLSAILGSIMSILFMV 294 Caenorhabditis ...
NP_587686    265 ----------------------------------ndvkqdtnsklgfvgclviFVVAFSGFSAYFLLNAYQASVPIYTSM 310 Schizosaccharom...
Feature 1                               #   #                                                    
Q8NHS3       297 MYAWtqeqavlYNGIILAALGVEAVVIFLGVKLLSKKi----GERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnn 372 human
Q19845       296 MFGLekeesvsINAGVHTVAGSIAAFMFICFIFTGVRry--mKNRVFTFISLSIPLVWLIATYPYKfysdhvqlmtngsn 373 Caenorhabditis ...
NP_001022903 297 MWGWtnaqaveYTGILQAVNGLVGVLVYALFAVKLGDyisqaRERIFTIFGLALGVLYHVVTYPYPwgpdlkyttinvti 376 Caenorhabditis ...
NP_505586    269 MYFQtrqeavaSMATTYLTTGFIATILYVLIIFTKLSti--vRDKIFNSLVLLLFVCHLLTTYSWQfysdsvldeefsne 346 Caenorhabditis ...
XP_009295888 309 YFGFge----lGNSVMYSLCGVEVIAGFFLVRWLSRVl----EDRVVLAVGLLICSGACVWCLIFLanpqggl------- 373 zebrafish
NP_001256536 263 MFNMerdsavgTMSIIFFIAGVFALSLYSTFVFTDVArk--lNIGKVNTISLIIFIIYVLTTYQWPyiptnvvvntdgth 340 Caenorhabditis ...
ERG81101     390 VFGYtntqtvkVGSFTQACVGVLSLLLFLGFASGRLNky--iSERQGALISCILFALFFLITYPWHfvgnpirikdvaan 467 pig roundworm
EPB73711     288 MFGLdnkqvlnYNAMMQGAVGVLTTVMFLVYVFTPYSkw--iSERLNCLGAMVALLFFHLLTFSWPflsgqlpdcakyvd 365 Ancylostoma cey...
NP_505339    295 QYGWtgtetvrFGSTMMIAFGFLACSILLLYIFCRLGqv--iPQEYVFLACTIAAGSYFIVTYPFSfnsqplapynssth 372 Caenorhabditis ...
NP_587686    311 LYNYss----fQAGNFLSLAGIINVPLLLIFSYLTRYl----TDRDIILLGCCLNIVCMVIHITIHytgke--------- 373 Schizosaccharom...
Feature 1                                                                ##   #   #              
Q8NHS3       373 sipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPkpQGV 452 human
Q19845       374 ancdt------------------------ekyswctdltkvneyvyyIGFIMVFGVAFSFMNITVTTLFSKVIGPrpQGT 429 Caenorhabditis ...
NP_001022903 377 hgknqtedl----------------gcnpakyhwctytkdvnfwlyaSMYGIVLAACFPIVNICMNTLFSKILGArrQGT 440 Caenorhabditis ...
NP_505586    347 tltgcd----------------------dihftwcdsltispqwafyIGYILSFGLFMPFINVANATLYSKLLNPdsQGT 404 Caenorhabditis ...
XP_009295888 374 ----------------------------------------gfelfefIIGVFLQLLGLPFVAVSQVSLFSKVTAEktQGF 413 zebrafish
NP_001256536 341 ggcdy------------------------slyswclglpktsqaffyIGYIIAFGGCVPFINVGDATLYSKLFNPvgQAL 396 Caenorhabditis ...
ERG81101     468 vtgcd-----------------------pevykwctdslyvkpgiylGSMVIVLGIAITLSTIAVDTLYSRILGNidQGT 524 pig roundworm
EPB73711     366 dvngt-----------------------qqgwawceslrpisfwlyyISYPLIFGLALPCLNNSLQSLYSQILGKgrQGT 422 Ancylostoma cey...
NP_505339    373 agcnp------------------------neytwcdtalavdpwvfmITTVIVFAPSLPMMGTSLDTVYSRVLGDidQNI 428 Caenorhabditis ...
NP_587686    374 ------------------------------------------fvqpyFIIYTLVFFGSSIANSPSVSLLTKVLHPkyHLI 411 Schizosaccharom...
Feature 1         #  ##  ##  #                                          
Q8NHS3       453 YMGWLTASGSGARILGPMFISQvyahwgPRWAFSLVCGIIVLTITLLGVVYKRLI 507 human
Q19845       430 YQGVYQMAGSFGRMLAPLLMSYvytlygPSIPWLILIVNLVVLISAWIILRVRMV 484 Caenorhabditis elegans
NP_001022903 441 MQGVMLMAGSFARTIGPLLVSWifqewgPEPIWIIEILTLSITAIFWMIFYRRMK 495 Caenorhabditis elegans
NP_505586    405 QQSLYDISNTTARIFAPIFITLiytvygPRRVWEFLCLLLLFTTFLWIIFDKRLV 459 Caenorhabditis elegans
XP_009295888 414 SQGVRRSVGGLATILGPLWAGGli--gnLYVMLGMMMLLLTLIMIMMVLSYEKLV 466 zebrafish
NP_001256536 397 EQSLYDVSQVFARVVAPVLCTAiyasfgPQRVWELLFAQLVVVTALWIAFAHRMI 451 Caenorhabditis elegans
ERG81101     525 MQGVFLFCMDIINILGPLVVAPmftasgQQRIWPIDEIVAIVATITCIAAYKKFP 579 pig roundworm
EPB73711     423 MQGVNQAVGCISRICGPLLMSTtfssfgPRGTWLIEIGLISLCIVTWCAVYRRLM 477 Ancylostoma ceylanicum
NP_505339    429 AHGFMTIVDDVIFMITPILTTSifaifgVGPLWIMKAVLFLSMGALWAFNLKELS 483 Caenorhabditis elegans
NP_587686    412 GNVAVQISISLSDTVGAIFGGAfrs-fsPVVFFAVCLILNVMSVLALLIIWKKLK 465 Schizosaccharomyces pombe 972h-

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