Conserved Protein Domain Family
DUF1258

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pfam06869: DUF1258 
Protein of unknown function (DUF1258)
This family represents a conserved region approximately 260 residues long within a number of hypothetical proteins of unknown function that seem to be specific to C. elegans. Note that this family contains a number of conserved cysteine and histidine residues.This family corresponds to the Mirage group of putative transposases and family members are relatively close homologs of Transposase_21 (pfam02992) proteins (1).
Statistics
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PSSM-Id: 429164
Aligned: 6 rows
Threshold Bit Score: 418.008
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFO95800      122 EASSLWNFRKGQYSIRKFCNSCG-VTASRDRCDRCDG-KVLKFIRIDAFSQLVDLVDRNLPKIMKLRENLKSGR-NSAHN 198 
2_pfamImport    1 LARNVWNYNRCTFSTHFFCNDCGrSLSKSERCKMCPNsCVAHYLRMGGFAQVCELVDAFLHEILKLRTDLKSGAvEVEHN 80  
EGT49951      115 DALRVWNFKKGMYSTLHVCNSCGkSVRNSETCE-CGG-KILKVTRVGAFSQLVDLVQEHSSKILKLREELRSGR-DKSHN 191 
XP_003094926 1645 SARKLWYHRRFNFSSHSFCNQCGrTVLSNDKCSLCGSnSIAVFVRTGGFSQIMQLVKTFKTEILTLRENLKAGK-NVEHN 1723
1_pfamImport    1 ---VLWNTEKKIFSVHFVCNKCGk---FSQKC--CG--PIVKFVRTGVFTQLTAIVDFYLDRIISIRRKLRAGD-EIDHP 69  
Q22778        159 SANSIWTYNKNNFSTHHFCNKCGkVAQNSKKCKYCGG-PVASFVRVGAFTQIVELVETYMDDILELREQLKNDR-NLEHN 236  Caenorhabditi...
EFO95800      199 LNAEYLKGRWKS-ETSKELNLTLLASVDGVTSHGNTKkKIWPITLKLADLPTSEMQKSINILLQGVIEGSENPSTVAWNQ 277 
2_pfamImport   81 LNSPFFSHSWKS-EGEYFLNLSLLMSVDGVDIPGTKN-KIWPVCFSLIDLPRGLSQKSTNIILQGVVQCLQNPTTALWNA 158 
EGT49951      192 LNSEFLKKNWIE-ESAGLLHLTLLASVDGVSLKGNSKkKIWPVTLKLADLPIAEMQKSVNILLEAIVEGVENPSTVLWNH 270 
XP_003094926 1724 LNSPFFESSWKM-ESGNHLNLSCVISIDGVQISGNTK-KLWPISLILVDLPSSQMQKSTNIILEGIIECSETPSTTLWNA 1801
1_pfamImport   70 LASPFLKPLWQAeKEEHSLLLSGVLSIDGVSVAGNTK-KLWPVSLILVDLPVAEMQRSSNVLLEGIAECVENPSTQFWNS 148 
Q22778        237 LASPFFSSFRET-ESPNRLRLSLVVSIDGVRISGNKK-KLWPVSYIIVDLPTGLMQKSTNIVLGGIVECSENPTTTLWNA 314  Caenorhabditi...
EFO95800      278 LLPTVFMDVEGRTGEAGGVRFNAKIVTFTADQP-----------AKRSLFGMTAANSESSCLFGLCTGTLHK-TRGAGGG 345 
2_pfamImport  159 LLPMICVDLESQTGKCAKYKFRATITTCTADQP-----------AKRSLFGFKGHTSSQSCFFCLSTETLHKtRGGESRS 227 
EGT49951      271 LIPIVFMDMENKVGEVDNIKFKASIVTFTADQP-----------AKRSLFGMAASNSEMSCFYGLCPGTLYK-TRGPERY 338 
XP_003094926 1802 VVPMIWTDIESYTGRIGVHSFSCRILSCSADQP-----------AKRSFFGMRSHQSSMSCFYCTSAGTMYK-LHGDSRK 1869
1_pfamImport  149 IQPLILSDLQSPRGVLSTCNFKLRCVTLTADQPfllfdnidilkAKRSFFGLRSHQSAKSCCYCLSDGTFYK-KDGPNRH 227 
Q22778        315 LIPFILSDVESHSGKVRNTSFTCHIRTCSADQP-----------AKRAFFGFMAHQSAESCFFCMSPGTLYK-FGDRKRR 382  Caenorhabditi...
EFO95800      346 TipTSKGVLTQQDSRSRNNGFKDIPPFV 373 
2_pfamImport  228 I--LRRGQLTINDSVHVRNGFKCKADIV 253 
EGT49951      339 T--SRKGILTQQDSLNAQNGFKNVPSFI 364 
XP_003094926 1870 Q--TRLGSLTVSDSINSINGFGRIPSTV 1895
1_pfamImport  228 D--VRNGNLTVEDSRQGVNGFGPTASNA 253 
Q22778        383 E--ERPGYETIVDSEQGVHGFGPIPAKI 408  Caenorhabditis elegans
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